Entity Details

Primary name MRP2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92887
EntryNameMRP2_HUMAN
FullNameATP-binding cassette sub-family C member 2
TaxID9606
Evidenceevidence at protein level
Length1545
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesABCC2

GO terms

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GOName
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006855 drug transmembrane transport
GO:0006954 inflammatory response
GO:0006979 response to oxidative stress
GO:0007565 female pregnancy
GO:0008514 organic anion transmembrane transporter activity
GO:0008559 ABC-type xenobiotic transporter activity
GO:0009408 response to heat
GO:0009986 cell surface
GO:0010629 negative regulation of gene expression
GO:0015127 bilirubin transmembrane transporter activity
GO:0015431 ABC-type glutathione S-conjugate transporter activity
GO:0015694 mercury ion transport
GO:0015721 bile acid and bile salt transport
GO:0015722 canalicular bile acid transport
GO:0015723 bilirubin transport
GO:0015732 prostaglandin transport
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0019904 protein domain specific binding
GO:0030644 cellular chloride ion homeostasis
GO:0031427 response to methotrexate
GO:0031526 brush border membrane
GO:0032355 response to estradiol
GO:0033762 response to glucagon
GO:0035690 cellular response to drug
GO:0038183 bile acid signaling pathway
GO:0042167 heme catabolic process
GO:0042178 xenobiotic catabolic process
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0042910 xenobiotic transmembrane transporter activity
GO:0043627 response to estrogen
GO:0046581 intercellular canaliculus
GO:0046618 drug export
GO:0046685 response to arsenic-containing substance
GO:0046691 intracellular canaliculus
GO:0055085 transmembrane transport
GO:0070327 thyroid hormone transport
GO:0070633 transepithelial transport
GO:0071222 cellular response to lipopolysaccharide
GO:0071347 cellular response to interleukin-1
GO:0071354 cellular response to interleukin-6
GO:0071356 cellular response to tumor necrosis factor
GO:0071549 cellular response to dexamethasone stimulus
GO:0071716 leukotriene transport
GO:0097327 response to antineoplastic agent
GO:0120188 regulation of bile acid secretion
GO:0150104 transport across blood-brain barrier
GO:1901086 benzylpenicillin metabolic process
GO:1904486 response to 17alpha-ethynylestradiol
GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane
GO:1990962 xenobiotic transport across blood-brain barrier

Subcellular Location

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Subcellular Location
Apical cell membrane

Domains

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DomainNameCategoryType
IPR003439 ABC transporter-like, ATP-binding domainDomainDomain
IPR003593 AAA+ ATPase domainDomainDomain
IPR005292 Multi drug resistance-associated proteinFamilyFamily
IPR011527 ABC transporter type 1, transmembrane domainDomainDomain
IPR017871 ABC transporter-like, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR030247 ATP-binding cassette sub-family C member 2FamilyFamily
IPR036640 ABC transporter type 1, transmembrane domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00067 VasopressinDrugbanksmall molecule
DB00091 CyclosporineDrugbanksmall molecule
DB00104 OctreotideSwissprotsmall molecule
DB00116 Tetrahydrofolic acidDrugbanksmall molecule
DB00143 GlutathioneDrugbanksmall molecule
DB00171 ATPDrugbanksmall molecule
DB00175 PravastatinDrugbanksmall molecule
DB00177 ValsartanDrugbanksmall molecule
DB00199 ErythromycinDrugbanksmall molecule
DB00206 ReserpineDrugbanksmall molecule
DB00207 AzithromycinDrugbanksmall molecule
DB00224 IndinavirDrugbanksmall molecule
DB00227 LovastatinDrugbanksmall molecule
DB00252 PhenytoinDrugbanksmall molecule
DB00275 OlmesartanDrugbanksmall molecule
DB00286 Conjugated estrogensDrugbanksmall molecule
DB00300 Tenofovir disoproxilDrugbanksmall molecule
DB00328 IndomethacinDrugbanksmall molecule
DB00345 Aminohippuric acidSwissprotsmall molecule
DB00365 GrepafloxacinDrugbanksmall molecule
DB00398 SorafenibDrugbanksmall molecule
DB00421 SpironolactoneDrugbanksmall molecule
DB00439 CerivastatinDrugbanksmall molecule
DB00481 RaloxifeneDrugbanksmall molecule
DB00503 RitonavirDrugbanksmall molecule
DB00515 CisplatinDrugbanksmall molecule
DB00526 OxaliplatinSwissprotsmall molecule
DB00541 VincristineDrugbanksmall molecule
DB00563 MethotrexateDrugbanksmall molecule
DB00564 CarbamazepineDrugbanksmall molecule
DB00570 VinblastineDrugbanksmall molecule
DB00602 IvermectinDrugbanksmall molecule
DB00641 SimvastatinDrugbanksmall molecule
DB00675 TamoxifenDrugbanksmall molecule
DB00688 Mycophenolate mofetilDrugbanksmall molecule
DB00694 DaunorubicinDrugbanksmall molecule
DB00695 FurosemideDrugbanksmall molecule
DB00698 NitrofurantoinDrugbanksmall molecule
DB00709 LamivudineDrugbanksmall molecule
DB00762 IrinotecanDrugbanksmall molecule
DB00773 EtoposideDrugbanksmall molecule
DB00795 SulfasalazineDrugbanksmall molecule
DB00876 EprosartanDrugbanksmall molecule
DB00908 QuinidineDrugbanksmall molecule
DB00950 FexofenadineDrugbanksmall molecule
DB00957 NorgestimateDrugbanksmall molecule
DB00958 CarboplatinSwissprotsmall molecule
DB00966 TelmisartanDrugbanksmall molecule
DB00973 EzetimibeDrugbanksmall molecule
DB00977 EthinylestradiolDrugbanksmall molecule
DB00978 LomefloxacinDrugbanksmall molecule
DB00997 DoxorubicinDrugbanksmall molecule
DB01016 GlyburideDrugbanksmall molecule
DB01032 ProbenecidDrugbanksmall molecule
DB01045 RifampicinDrugbanksmall molecule
DB01076 AtorvastatinDrugbanksmall molecule
DB01095 FluvastatinDrugbanksmall molecule
DB01098 RosuvastatinDrugbanksmall molecule
DB01115 NifedipineDrugbanksmall molecule
DB01138 SulfinpyrazoneDrugbanksmall molecule
DB01165 OfloxacinDrugbanksmall molecule
DB01169 Arsenic trioxideDrugbanksmall molecule
DB01174 PhenobarbitalDrugbanksmall molecule
DB01208 SparfloxacinDrugbanksmall molecule
DB01229 PaclitaxelDrugbanksmall molecule
DB01232 SaquinavirDrugbanksmall molecule
DB01234 DexamethasoneDrugbanksmall molecule
DB01248 DocetaxelDrugbanksmall molecule
DB01268 SunitinibDrugbanksmall molecule
DB01411 PranlukastDrugbanksmall molecule
DB01586 Ursodeoxycholic acidDrugbanksmall molecule
DB01892 HyperforinDrugbanksmall molecule
DB02659 Cholic AcidDrugbanksmall molecule
DB02703 Fusidic acidDrugbanksmall molecule
DB04100 Tricarbonyl(1,10-phenanthroline)rhenium(1+)Drugbanksmall molecule
DB04216 QuercetinDrugbanksmall molecule
DB04348 Taurocholic acidDrugbanksmall molecule
DB04789 5-methyltetrahydrofolic acidDrugbanksmall molecule
DB06290 SimeprevirDrugbanksmall molecule
DB06448 LonafarnibDrugbanksmall molecule
DB06813 PralatrexateDrugbanksmall molecule
DB08860 PitavastatinDrugbanksmall molecule
DB08884 Gadoxetic acidSwissprotsmall molecule
DB08907 CanagliflozinDrugbanksmall molecule
DB09060 AvibactamDrugbanksmall molecule
DB09272 EluxadolineDrugbanksmall molecule
DB09374 Indocyanine green acid formSwissprotsmall molecule
DB11770 TalinololSwissprotsmall molecule
DB12070 LetermovirDrugbanksmall molecule
DB14642 LypressinDrugbanksmall molecule
DB14649 Dexamethasone acetateDrugbanksmall molecule
DB15719 Belantamab mafodotinDrugbankbiotech