Entity Details

Primary name OTUB1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96FW1
EntryNameOTUB1_HUMAN
FullNameUbiquitin thioesterase OTUB1
TaxID9606
Evidenceevidence at protein level
Length271
SequenceStatuscomplete
DateCreated2004-03-01
DateModified2021-06-02

Ontological Relatives

GenesOTUB1

GO terms

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GOName
GO:0002250 adaptive immune response
GO:0004843 thiol-dependent deubiquitinase
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0016579 protein deubiquitination
GO:0019784 NEDD8-specific protease activity
GO:0031625 ubiquitin protein ligase binding
GO:0043130 ubiquitin binding
GO:0070062 extracellular exosome
GO:0071108 protein K48-linked deubiquitination
GO:1901315 negative regulation of histone H2A K63-linked ubiquitination
GO:2000780 negative regulation of double-strand break repair

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR003323 OTU domainDomainDomain
IPR016615 Ubiquitin thioesterase OtubainFamilyFamily
IPR019400 Peptidase C65, otubainFamilyFamily
IPR030298 Ubiquitin thioesterase OTUB1FamilyFamily
IPR038765 Papain-like cysteine peptidase superfamilyFamilyHomologous superfamily
IPR042467 Peptidase C65, otubain, subdomain 2FamilyHomologous superfamily
IPR042468 Peptidase C65, otubain, subdomain 1FamilyHomologous superfamily

Diseases

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Interactions

126 interactions

InteractorPartnerSourcesPublicationsLink
OTUB1_HUMANUBC_HUMANBioGRID, MINT11689694 17550899 18954305 19211026 20622874 22325355 23287719 23562397 23827681 23955022 24071738 25527291 25590432 25723849 25752577 25872870 26752685 26876099 27066941 27182664 27256865 28190767 29576527 30718280 32049508 details
OTUB1_HUMANSMAD9_HUMANBioGRID, HPRD, MINT15231748 details
OTUB1_HUMANVHL_HUMANIntAct17353931 32814053 details
OTUB1_HUMANUB2D1_HUMANBioGRID, IntAct, MINT19549727 22124327 24071738 24403071 26752685 32049508 32296183 details
OTUB1_HUMANUB2D2_HUMANBioGRID, IntAct, MINT19549727 19615732 20725033 22124327 22325355 23287719 26186194 26752685 28514442 30718280 32049508 32296183 details
OTUB1_HUMANUB2D3_HUMANBioGRID, IntAct, MINT19549727 22124327 24403071 25416956 26752685 32049508 32296183 32842143 details
OTUB1_HUMANUB2E1_HUMANBioGRID, IntAct19549727 26752685 28073915 32049508 details
OTUB1_HUMANUBE2N_HUMANBioGRID, DIP, IntAct19615732 20725033 22367539 22679021 24071738 25872870 26752685 27173435 27909234 30718280 32049508 unassigned1312 details
OTUB1_HUMANOTUB1_HUMANBioGRID, IntAct19615732 32005664 details
OTUB1_HUMANRHOA_HUMANBioGRID, MINT20553488 details
OTUB1_HUMANANXA1_HUMANBioGRID, MINT21900206 details
OTUB1_HUMANANXA7_HUMANBioGRID, MINT21900206 details
OTUB1_HUMANCDN1A_HUMANBioGRID, MINT21900206 details
OTUB1_HUMANH2AX_HUMANBioGRID, MINT21900206 details
OTUB1_HUMANT22D1_HUMANBioGRID, MINT21900206 details
OTUB1_HUMANTTHY_HUMANBioGRID, IntAct, MINT21900206 32814053 details
OTUB1_HUMANP53_HUMANBioGRID, MINT22124327 24403071 27561390 details
OTUB1_HUMANMDM2_HUMANMINT22124327 details
OTUB1_HUMANKDM1A_HUMANBioGRID, MINT23455924 details
OTUB1_HUMANBIRC2_HUMANBioGRID, MINT23524849 details
OTUB1_HUMANUB2D4_HUMANBioGRID, IntAct25416956 31515488 32296183 details
OTUB1_HUMANHIF1N_HUMANBioGRID, IntAct26752685 26972000 28514442 31299612 details
OTUB1_HUMANUB2E2_HUMANBioGRID, IntAct26752685 28514442 32296183 details
OTUB1_HUMANUB2E3_HUMANBioGRID, IntAct26752685 28514442 32296183 details
OTUB1_HUMANTADBP_HUMANBioGRID, IntAct26752685 32814053 details
OTUB1_HUMANUB2L3_HUMANBioGRID, IntAct23563141 26752685 details
OTUB1_HUMANBAG6_HUMANBioGRID, IntAct26752685 32814053 details
OTUB1_HUMANPARK7_HUMANIntAct26752685 32814053 details
OTUB1_HUMANUBA1_HUMANIntAct26752685 32814053 details
OTUB1_HUMANA2MG_HUMANIntAct32814053 details
OTUB1_HUMANTPP1_HUMANIntAct32814053 details
OTUB1_HUMANDCTN1_HUMANIntAct32814053 details
OTUB1_HUMANDYN2_HUMANIntAct32814053 details
OTUB1_HUMANGFAP_HUMANIntAct32814053 details
OTUB1_HUMANGLE1_HUMANIntAct32814053 details
OTUB1_HUMANGRN_HUMANIntAct32814053 details
OTUB1_HUMANHEXB_HUMANIntAct32814053 details
OTUB1_HUMANHSPB1_HUMANIntAct32814053 details
OTUB1_HUMANMECP2_HUMANIntAct32814053 details
OTUB1_HUMANNDUV2_HUMANIntAct32814053 details
OTUB1_HUMANMERL_HUMANIntAct32814053 details
OTUB1_HUMANPRKN_HUMANIntAct32814053 details
OTUB1_HUMANPRPS1_HUMANIntAct32814053 details
OTUB1_HUMANPSN1_HUMANIntAct32814053 details
OTUB1_HUMANICAM5_HUMANIntAct32814053 details
OTUB1_HUMANUBB_HUMANIntAct32814053 details
OTUB1_HUMANBRK1_HUMANIntAct32814053 details
OTUB1_HUMANWFS1_HUMANIntAct32814053 details
OTUB1_HUMANIDLC_HUMANIntAct32814053 details
OTUB1_HUMANKLF11_HUMANIntAct32814053 details
OTUB1_HUMANDNJB6_HUMANIntAct32814053 details
OTUB1_HUMANKIF1B_HUMANIntAct32814053 details
OTUB1_HUMANRNF11_HUMANIntAct32814053 details
OTUB1_HUMANHTRA2_HUMANIntAct32814053 details
OTUB1_HUMANJPH3_HUMANIntAct32814053 details
OTUB1_HUMANSPRE1_HUMANIntAct32814053 details
OTUB1_HUMANSODC_HUMANIntAct32814053 details
OTUB1_HUMANA4_HUMANIntAct32814053 details
OTUB1_HUMANFUS_HUMANBioGRID, IntAct18954305 32814053 details
OTUB1_HUMANSYUA_HUMANIntAct32814053 details
OTUB1_HUMANATX1_HUMANIntAct32814053 details
OTUB1_HUMANRN128_HUMANBioGRID14661020 details
OTUB1_HUMANTRAF6_HUMANBioGRID19996094 20622874 details
OTUB1_HUMANESR1_HUMANBioGRID19383985 details
OTUB1_HUMANUBE2S_HUMANBioGRID20622874 details
OTUB1_HUMANUB2V2_HUMANBioGRID22679021 details
OTUB1_HUMANRFFL_HUMANBioGRID22626734 details
OTUB1_HUMANPJA1_HUMANBioGRID22626734 details
OTUB1_HUMANTRI63_HUMANBioGRID22626734 details
OTUB1_HUMANTRI55_HUMANBioGRID22626734 details
OTUB1_HUMANTRI54_HUMANBioGRID22626734 details
OTUB1_HUMANUBP21_HUMANBioGRID22626734 details
OTUB1_HUMANUBP15_HUMANBioGRID22626734 details
OTUB1_HUMANUBP28_HUMANBioGRID22626734 details
OTUB1_HUMANECT2_HUMANBioGRID22990118 details
OTUB1_HUMANRN126_HUMANBioGRID23105109 details
OTUB1_HUMANSMAD2_HUMANBioGRID24071738 details
OTUB1_HUMANSMAD3_HUMANBioGRID24071738 details
OTUB1_HUMANSMAD4_HUMANBioGRID24071738 details
OTUB1_HUMANNEDD8_HUMANBioGRID18954305 details
OTUB1_HUMANCSK21_HUMANBioGRID25872870 details
OTUB1_HUMANACVR1_HUMANBioGRID25872870 details
OTUB1_HUMANBMR1A_HUMANBioGRID25872870 details
OTUB1_HUMANACV1B_HUMANBioGRID25872870 details
OTUB1_HUMANTGFR1_HUMANBioGRID25872870 details
OTUB1_HUMANBMR1B_HUMANBioGRID25872870 details
OTUB1_HUMANFOXM1_HUMANBioGRID26148240 27167337 31879190 details
OTUB1_HUMANAURKA_HUMANBioGRID26446837 details
OTUB1_HUMANILRL2_HUMANBioGRID29176319 details
OTUB1_HUMANCPEB2_HUMANBioGRID22157746 details
OTUB1_HUMANSNAI1_HUMANBioGRID29559747 31911859 details
OTUB1_HUMANUBE4B_HUMANBioGRID29326975 details
OTUB1_HUMANTAU_HUMANBioGRID28083634 details
OTUB1_HUMANXCT_HUMANBioGRID30709928 details
OTUB1_HUMANUBE2Z_HUMANBioGRID30718280 details
OTUB1_HUMANUBA6_HUMANBioGRID30718280 details
OTUB1_HUMANUBD_HUMANBioGRID30718280 details
OTUB1_HUMANEIF1B_HUMANIntAct17353931 details
OTUB1_HUMANATG5_HUMANIntAct17353931 details
OTUB1_HUMANCNOT8_HUMANIntAct17353931 details
OTUB1_HUMANTNIK_HUMANIntAct17353931 details
OTUB1_HUMANCRCM_HUMANIntAct17353931 details
OTUB1_HUMANSOMA_HUMANIntAct17353931 details
OTUB1_HUMANIKKE_HUMANIntAct17353931 details
OTUB1_HUMANAAKB1_HUMANIntAct17353931 details
OTUB1_HUMANPCNA_HUMANBioGRID, IntAct18954305 26752685 details
OTUB1_HUMANUBP8_HUMANBioGRID14661020 details
OTUB1_HUMANDDX5_HUMANBioGRID18954305 details
OTUB1_HUMANRACK1_HUMANBioGRID18954305 details
OTUB1_HUMANNPM_HUMANBioGRID18954305 details
OTUB1_HUMANEBP2_HUMANBioGRID18954305 details
OTUB1_HUMANIF4A3_HUMANBioGRID18954305 details
OTUB1_HUMANDDX54_HUMANBioGRID18954305 details
OTUB1_HUMANDDX23_HUMANBioGRID18954305 details
OTUB1_HUMANNAT10_HUMANBioGRID18954305 details
OTUB1_HUMANDDX24_HUMANBioGRID18954305 details
OTUB1_HUMANTRAF3_HUMANBioGRID19996094 24763515 31386800 details
OTUB1_HUMANMAVS_HUMANBioGRID19996094 details
OTUB1_HUMANACTB_HUMANBioGRID16364312 details
OTUB1_HUMANNMRL1_HUMANBioGRID24763515 details
OTUB1_HUMANDPTOR_HUMANBioGRID29382726 details
OTUB1_HUMANCTNB1_HUMANBioGRID30323974 details
OTUB1_HUMANCD44_HUMANBioGRID30709928 details
OTUB1_HUMANNR4A1_HUMANBioGRID30905540 details
OTUB1_HUMANMSRE_HUMANBioGRID31386800 details
OTUB1_HUMANMAF_HUMANBioGRID32842143 details