Entity Details

Primary name CSKP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14936
EntryNameCSKP_HUMAN
FullNamePeripheral plasma membrane protein CASK
TaxID9606
Evidenceevidence at protein level
Length926
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesCASK

GO terms

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GOName
GO:0001953 negative regulation of cell-matrix adhesion
GO:0004385 guanylate kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0005604 basement membrane
GO:0005652 nuclear lamina
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005925 focal adhesion
GO:0006836 neurotransmitter transport
GO:0007155 cell adhesion
GO:0010839 negative regulation of keratinocyte proliferation
GO:0015629 actin cytoskeleton
GO:0016363 nuclear matrix
GO:0042734 presynaptic membrane
GO:0060170 ciliary membrane
GO:0061045 negative regulation of wound healing
GO:0090288 negative regulation of cellular response to growth factor stimulus
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR001478 PDZ domainDomainDomain
IPR004172 L27 domainDomainDomain
IPR008144 Guanylate kinase-like domainDomainDomain
IPR008145 Guanylate kinase/L-type calcium channel beta subunitDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR014775 L27 domain, C-terminalDomainDomain
IPR020590 Guanylate kinase, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR035473 CASK, SH3 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036034 PDZ superfamilyFamilyHomologous superfamily
IPR036892 L27 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01942 Formic acidDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

97 interactions

InteractorPartnerSourcesPublicationsLink
CSKP_HUMANTBR1_HUMANBioGRID, HPRD, MINT10749215 11377421 15066269 details
CSKP_HUMANRP3A_HUMANBioGRID, HPRD, MINT11377421 details
CSKP_HUMANJAM1_HUMANBioGRID, MINT10856295 11120739 details
CSKP_HUMANCNTP2_HUMANBioGRID, HPRD, MINT12093160 details
CSKP_HUMANCNTP4_HUMANBioGRID, HPRD, MINT12093160 details
CSKP_HUMANKPCD2_HUMANBioGRID, MINT15231748 details
CSKP_HUMANLIN7A_HUMANBioGRID, HPRD, IntAct, MINT14960569 16688213 24366813 25416956 32296183 9753324 details
CSKP_HUMANID1_HUMANBioGRID, HPRD, IntAct15694377 details
CSKP_HUMANSDC2_HUMANBioGRID, HPRD, IntAct12676536 9660868 details
CSKP_HUMANEPB41_HUMANBioGRID, HPRD, IntAct9660868 details
CSKP_HUMANBNI3L_HUMANBioGRID, IntAct21988832 details
CSKP_HUMANCDK9_HUMANBioGRID, IntAct21988832 details
CSKP_HUMANDUS3_HUMANBioGRID, IntAct21988832 details
CSKP_HUMANI15RA_HUMANBioGRID, IntAct21988832 details
CSKP_HUMANIL18_HUMANBioGRID, IntAct21988832 details
CSKP_HUMANSYMC_HUMANBioGRID, IntAct21988832 details
CSKP_HUMANAF17_HUMANBioGRID, IntAct21988832 details
CSKP_HUMANP2RX7_HUMANBioGRID, IntAct21988832 details
CSKP_HUMANEP300_HUMANIntAct21988832 details
CSKP_HUMANPCM1_HUMANBioGRID, IntAct21988832 30217970 details
CSKP_HUMANWNT7B_HUMANBioGRID, IntAct21988832 details
CSKP_HUMANGCNT3_HUMANBioGRID, IntAct21988832 details
CSKP_HUMANTRI22_HUMANBioGRID, IntAct21988832 details
CSKP_HUMANPLK2_HUMANBioGRID, IntAct21988832 details
CSKP_HUMANELL2_HUMANBioGRID, IntAct21988832 details
CSKP_HUMANP4R3A_HUMANBioGRID, IntAct21988832 details
CSKP_HUMANWHRN_HUMANHPRD, MINT12641734 22117215 details
CSKP_HUMANSRPK2_HUMANBioGRID, IntAct23602568 details
CSKP_HUMANCSKI1_HUMANDIP, HPRD, IntAct12040031 21763699 22153505 details
CSKP_HUMANAPBA1_HUMANBioGRID, HPRD, IntAct21763699 9753324 9822620 9952408 details
CSKP_HUMANSH24A_HUMANBioGRID, IntAct25416956 29892012 32296183 details
CSKP_HUMANPGH2_HUMANBioGRID, IntAct24722188 details
CSKP_HUMANMLX_HUMANBioGRID, IntAct32296183 details
CSKP_HUMANNET4_HUMANBioGRID, IntAct32296183 details
CSKP_HUMANLIN7B_HUMANBioGRID, HPRD, IntAct11742811 14960569 32296183 details
CSKP_HUMANCT085_HUMANBioGRID, IntAct32296183 details
CSKP_HUMANDNJC5_HUMANBioGRID, IntAct29997244 33957083 details
CSKP_HUMANADA10_HUMANUniProt25036101 details
CSKP_HUMANTSYL2_HUMANBioGRID, HPRD15066269 details
CSKP_HUMANDLG1_HUMANBioGRID, HPRD10993877 12151521 12351654 14960569 23864692 25852190 details
CSKP_HUMANFCSD2_HUMANBioGRID, HPRD14627983 details
CSKP_HUMANDLG4_HUMANBioGRID, HPRD12151521 details
CSKP_HUMANAT2B4_HUMANBioGRID, HPRD12511555 details
CSKP_HUMANPRKN_HUMANBioGRID, HPRD11679592 21590270 details
CSKP_HUMANSDC1_HUMANBioGRID, HPRD9660868 details
CSKP_HUMANHGS_HUMANBioGRID19019082 details
CSKP_HUMANERBIN_HUMANBioGRID15123239 details
CSKP_HUMANPCBP2_HUMANBioGRID21988832 details
CSKP_HUMANRBM14_HUMANBioGRID30217970 details
CSKP_HUMANAKAP9_HUMANBioGRID30217970 details
CSKP_HUMANNDEL1_HUMANBioGRID30217970 details
CSKP_HUMANPRC1_HUMANBioGRID30217970 details
CSKP_HUMANPKP2_HUMANBioGRID30217970 details
CSKP_HUMANSF3B2_HUMANBioGRID30217970 details
CSKP_HUMANDDX54_HUMANBioGRID30217970 details
CSKP_HUMANMED1_HUMANBioGRID30217970 details
CSKP_HUMANKPCI_HUMANBioGRID30217970 details
CSKP_HUMANMARK2_HUMANBioGRID30217970 details
CSKP_HUMANRFA2_HUMANBioGRID30217970 details
CSKP_HUMANGTSE1_HUMANBioGRID30217970 details
CSKP_HUMANKLC4_HUMANBioGRID30217970 details
CSKP_HUMANMARE2_HUMANBioGRID30217970 details
CSKP_HUMANRBM10_HUMANBioGRID30217970 details
CSKP_HUMANKIF2A_HUMANBioGRID30217970 details
CSKP_HUMAN1433E_HUMANBioGRID30217970 details
CSKP_HUMANPAR6G_HUMANBioGRID30217970 details
CSKP_HUMANPAR3L_HUMANBioGRID30217970 details
CSKP_HUMANFMR1_HUMANBioGRID30217970 details
CSKP_HUMANSLAI2_HUMANBioGRID30217970 details
CSKP_HUMANMARE1_HUMANBioGRID30217970 details
CSKP_HUMANPRPF3_HUMANBioGRID30217970 details
CSKP_HUMANRBM5_HUMANBioGRID30217970 details
CSKP_HUMANRBBP6_HUMANBioGRID30217970 details
CSKP_HUMANRAB3A_HUMANHPRD11377421 details
CSKP_HUMANCSKP_HUMANHPRD12040031 12093160 12641734 15024025 9660869 9822620 9952408 details
CSKP_HUMANSDC4_HUMANHPRD9660868 details
CSKP_HUMANNRX3A_HUMANHPRD8786425 details
CSKP_HUMANNRX1A_HUMANHPRD11036064 8786425 details
CSKP_HUMANNRX2A_HUMANHPRD8786425 details
CSKP_HUMANARHG7_HUMANMINT15975580 details
CSKP_HUMANEPS8_HUMANHPRD, MINT16688213 details
CSKP_HUMANTIAM1_HUMANIntAct21763699 details
CSKP_HUMANLIN7C_HUMANBioGRID, IntAct14960569 25852190 26186194 28514442 details
CSKP_HUMANKIRR3_HUMANIntAct19012874 details
CSKP_HUMANKCJ12_HUMANBioGRID, HPRD14960569 15024025 details
CSKP_HUMANKCNJ4_HUMANBioGRID, HPRD11742811 14960569 15024025 details
CSKP_HUMANARI1_HUMANBioGRID21590270 details
CSKP_HUMANFRMD7_HUMANBioGRID23406872 details
CSKP_HUMANSDC3_HUMANHPRD10460248 details
CSKP_HUMANKCNJ2_HUMANHPRD15024025 details
CSKP_HUMANNPHN_HUMANHPRD15331416 details
CSKP_HUMANCADM1_HUMANHPRD12202822 details
CSKP_HUMANTANC1_HUMANHPRD15673434 details
CSKP_HUMANNMDE1_HUMANHPRD16637659 details
CSKP_HUMANKCNA4_HUMANHPRD16637659 details
CSKP_HUMANGLSL_HUMANHPRD16637659 details
CSKP_HUMANGRIK2_HUMANHPRD12151522 details