Entity Details

Primary name VPS35_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ96QK1
EntryNameVPS35_HUMAN
FullNameVacuolar protein sorting-associated protein 35
TaxID9606
Evidenceevidence at protein level
Length796
SequenceStatuscomplete
DateCreated2002-11-25
DateModified2021-06-02

Ontological Relatives

GenesVPS35

GO terms

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GOName
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005829 cytosol
GO:0006886 intracellular protein transport
GO:0010008 endosome membrane
GO:0010628 positive regulation of gene expression
GO:0010821 regulation of mitochondrion organization
GO:0016032 viral process
GO:0016055 Wnt signaling pathway
GO:0016241 regulation of macroautophagy
GO:0030904 retromer complex
GO:0030906 retromer, cargo-selective complex
GO:0031647 regulation of protein stability
GO:0031748 D1 dopamine receptor binding
GO:0032268 regulation of cellular protein metabolic process
GO:0032456 endocytic recycling
GO:0036010 protein localization to endosome
GO:0042147 retrograde transport, endosome to Golgi
GO:0043653 mitochondrial fragmentation involved in apoptotic process
GO:0045056 transcytosis
GO:0050728 negative regulation of inflammatory response
GO:0060161 positive regulation of dopamine receptor signaling pathway
GO:0060548 negative regulation of cell death
GO:0070062 extracellular exosome
GO:0090141 positive regulation of mitochondrial fission
GO:0097422 tubular endosome
GO:0099073 mitochondrion-derived vesicle
GO:0099074 mitochondrion to lysosome transport
GO:0099639 neurotransmitter receptor transport, endosome to plasma membrane
GO:1901215 negative regulation of neuron death
GO:1902823 negative regulation of late endosome to lysosome transport
GO:1902950 regulation of dendritic spine maintenance
GO:1903364 positive regulation of cellular protein catabolic process
GO:1905606 regulation of presynapse assembly
GO:2000331 regulation of terminal button organization

Subcellular Location

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Subcellular Location
Cytoplasm
Early endosome
Endosome
Late endosome
Membrane

Domains

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DomainNameCategoryType
IPR005378 Vacuolar protein sorting-associated protein 35FamilyFamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR042491 Vacuolar protein sorting-associated protein 35, C-terminalFamilyHomologous superfamily

Diseases

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Interactions

35 interactions

InteractorPartnerSourcesPublicationsLink
VPS35_HUMANZ512B_HUMANBioGRID, MINT15231748 details
VPS35_HUMANMTR1B_HUMANBioGRID, HPRD, IntAct17215244 26514267 details
VPS35_HUMANVEGFA_HUMANBioGRID, IntAct21988832 details
VPS35_HUMANVP26A_HUMANBioGRID, DIP, IntAct, UniProt11102511 15078903 16732284 17891154 22863883 22939629 24344282 24747528 24819384 26186194 26344197 26496610 28514442 29893854 32296183 details
VPS35_HUMANVPS29_HUMANBioGRID, DIP, HPRD, IntAct, UniProt11102511 17891154 22863883 22939629 24344282 24747528 25416956 25502805 26344197 28514442 29893854 31515488 32296183 details
VPS35_HUMANMPRI_HUMANUniProt15078903 details
VPS35_HUMANVP26B_HUMANBioGRID, HPRD, IntAct16190980 22939629 26186194 26344197 26496610 28514442 32296183 details
VPS35_HUMANA4_HUMANBioGRID, IntAct21832049 32814053 details
VPS35_HUMANWAC2C_HUMANBioGRID20923837 24819384 details
VPS35_HUMANSNX3_HUMANBioGRID22673115 24344282 details
VPS35_HUMANRAB7A_HUMANBioGRID24344282 29893854 details
VPS35_HUMANNRAM2_HUMANBioGRID24344282 details
VPS35_HUMANDRD1_HUMANBioGRID27460146 details
VPS35_HUMANVHL_HUMANIntAct17353931 details
VPS35_HUMANGBRL2_HUMANIntAct17353931 details
VPS35_HUMANHLAB_HUMANIntAct17353931 details
VPS35_HUMANTRAF6_HUMANIntAct17353931 details
VPS35_HUMANAAKB1_HUMANIntAct17353931 details
VPS35_HUMANATG9A_HUMANMINT24603492 details
VPS35_HUMANSNX1_HUMANBioGRID, HPRD, UniProt11102511 26344197 details
VPS35_HUMANTBCD5_HUMANBioGRID, UniProt20923837 22354992 details
VPS35_HUMANDISC1_HUMANIntAct31413325 details
VPS35_HUMANMUL1_HUMANBioGRID20619655 details
VPS35_HUMANHGS_HUMANBioGRID19874558 details
VPS35_HUMANMAGL2_HUMANBioGRID23452853 details
VPS35_HUMANVPS35_HUMANBioGRID23452853 details
VPS35_HUMANAIMP2_HUMANBioGRID28383562 details
VPS35_HUMANLAMP2_HUMANBioGRID28383562 details
VPS35_HUMANEEA1_HUMANBioGRID29891722 details
VPS35_HUMANMMP14_HUMANBioGRID29891722 details
VPS35_HUMANPRKN_HUMANBioGRID29893854 details
VPS35_HUMANRAB5A_HUMANBioGRID29893854 details
VPS35_HUMANLAMP1_HUMANBioGRID29893854 details
VPS35_HUMANGOGA4_HUMANBioGRID29893854 details
VPS35_HUMANWASH1_HUMANBioGRID29893854 details