Entity Details

Primary name EPAS1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99814
EntryNameEPAS1_HUMAN
FullNameEndothelial PAS domain-containing protein 1
TaxID9606
Evidenceevidence at protein level
Length870
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesEPAS1

GO terms

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GOName
GO:0000785 chromatin
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001525 angiogenesis
GO:0001666 response to hypoxia
GO:0001892 embryonic placenta development
GO:0001974 blood vessel remodeling
GO:0002027 regulation of heart rate
GO:0003677 DNA binding
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007005 mitochondrion organization
GO:0007165 signal transduction
GO:0007601 visual perception
GO:0008134 transcription factor binding
GO:0016567 protein ubiquitination
GO:0016607 nuclear speck
GO:0030218 erythrocyte differentiation
GO:0030324 lung development
GO:0035019 somatic stem cell population maintenance
GO:0035035 histone acetyltransferase binding
GO:0042415 norepinephrine metabolic process
GO:0043129 surfactant homeostasis
GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0043687 post-translational protein modification
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046982 protein heterodimerization activity
GO:0048469 cell maturation
GO:0048625 myoblast fate commitment
GO:0055072 iron ion homeostasis
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456 cellular response to hypoxia
GO:0120162 positive regulation of cold-induced thermogenesis
GO:2000434 regulation of protein neddylation

Subcellular Location

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Subcellular Location
Nucleus
Nucleus speckle

Domains

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DomainNameCategoryType
IPR000014 PAS domainDomainDomain
IPR001067 Nuclear translocatorFamilyFamily
IPR001610 PAC motifRepeatRepeat
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR013655 PAS fold-3DomainDomain
IPR013767 PAS foldDomainDomain
IPR014887 HIF-1 alpha, transactivation domain, C-terminalDomainDomain
IPR021537 Hypoxia-inducible factor, alpha subunitFamilyFamily
IPR035965 PAS domain superfamilyFamilyHomologous superfamily
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB15463 PT2977Drugbanksmall molecule

Interactions

82 interactions

InteractorPartnerSourcesPublicationsLink
EPAS1_HUMANEP300_HUMANBioGRID, HPRD, IntAct15261140 22807441 23275444 25689462 details
EPAS1_HUMANSMAD3_HUMANBioGRID, HPRD, IntAct, MINT15231748 21057546 25241761 details
EPAS1_HUMANPDK1_HUMANMINT17024177 details
EPAS1_HUMANEIF3E_HUMANHPRD, IntAct17324924 details
EPAS1_HUMANVHL_HUMANBioGRID, HPRD, IntAct, MINT10353251 10823831 10878807 11292862 11331613 12604794 15611064 17339318 17967880 17986458 21685897 23401859 24981860 25500545 26342197 26735578 28775317 30487161 details
EPAS1_HUMANBMAL2_HUMANBioGRID, HPRD, IntAct11018023 32296183 details
EPAS1_HUMANARNT_HUMANBioGRID, DIP, HPRD, IntAct, MINT11018023 14668441 15192019 16181639 19129502 19845609 23275444 23434853 23796364 24981860 26160453 32461361 9079689 details
EPAS1_HUMANBMAL1_HUMANBioGRID, HPRD, IntAct11018023 32296183 9576906 details
EPAS1_HUMANBBS1_HUMANBioGRID, IntAct18000879 details
EPAS1_HUMANBBS4_HUMANBioGRID, IntAct18000879 details
EPAS1_HUMANBBS2_HUMANBioGRID, IntAct18000879 details
EPAS1_HUMANAPC_HUMANBioGRID, IntAct20936779 details
EPAS1_HUMANMEF2C_HUMANBioGRID, IntAct20936779 details
EPAS1_HUMANEWS_HUMANBioGRID, IntAct21988832 details
EPAS1_HUMANSTA5A_HUMANBioGRID, IntAct21988832 details
EPAS1_HUMANEGLN1_HUMANBioGRID, HPRD, IntAct15474027 16407130 17353276 19147576 19208626 23275444 30487161 31763849 details
EPAS1_HUMANEGLN2_HUMANBioGRID, HPRD, IntAct15474027 17353276 23275444 details
EPAS1_HUMANEGLN3_HUMANBioGRID, HPRD, IntAct15474027 17353276 17684156 23275444 details
EPAS1_HUMANUBP8_HUMANMINT24378640 details
EPAS1_HUMANTE2IP_HUMANbhf-ucl, BioGRID21044950 details
EPAS1_HUMANF16P1_HUMANDIP25043030 details
EPAS1_HUMANARNT2_HUMANBioGRID, IntAct20211142 23275444 details
EPAS1_HUMANFA12_HUMANBioGRID21512133 details
EPAS1_HUMANOSTP_HUMANBioGRID22779921 details
EPAS1_HUMANHS90A_HUMANBioGRID15319539 details
EPAS1_HUMANKLH20_HUMANBioGRID21888897 details
EPAS1_HUMANEPAS1_HUMANBioGRID23275444 23661758 details
EPAS1_HUMANNECD_HUMANBioGRID23785149 details
EPAS1_HUMANBATF3_HUMANBioGRID23661758 details
EPAS1_HUMANBATF2_HUMANBioGRID23661758 details
EPAS1_HUMANBATF_HUMANBioGRID23661758 details
EPAS1_HUMANJUN_HUMANBioGRID23661758 25879517 details
EPAS1_HUMANDBP_HUMANBioGRID23661758 details
EPAS1_HUMANDDIT3_HUMANBioGRID23661758 details
EPAS1_HUMANSIR1_HUMANBioGRID22807441 details
EPAS1_HUMANNEMO_HUMANBioGRID15653678 26500060 details
EPAS1_HUMANESR1_HUMANBioGRID27323688 details
EPAS1_HUMANIMA5_HUMANBioGRID18187047 details
EPAS1_HUMANIMA4_HUMANBioGRID18187047 details
EPAS1_HUMANIMA6_HUMANBioGRID18187047 details
EPAS1_HUMANIMA7_HUMANBioGRID18187047 details
EPAS1_HUMANIMB1_HUMANBioGRID18187047 details
EPAS1_HUMANETV4_HUMANBioGRID22075993 details
EPAS1_HUMANUBP20_HUMANBioGRID32296183 details
EPAS1_HUMANSP1_HUMANBioGRID, MINT17024177 22402494 details
EPAS1_HUMANMAX_HUMANBioGRID, HPRD, IntAct17418410 details
EPAS1_HUMANSUMO1_HUMANI2D20661221 details
EPAS1_HUMANPIAS2_HUMANI2D20661221 details
EPAS1_HUMANKPYM_HUMANIntAct21620138 details
EPAS1_HUMANRNC_HUMANIntAct26766590 details
EPAS1_HUMANIF4E2_HUMANDIP22678294 details
EPAS1_HUMANRBM4_HUMANDIP22678294 details
EPAS1_HUMANPRS6A_HUMANBioGRID14556007 details
EPAS1_HUMANMCM3_HUMANBioGRID21658608 details
EPAS1_HUMANMCM7_HUMANBioGRID21658608 details
EPAS1_HUMANCHIP_HUMANBioGRID19940151 details
EPAS1_HUMANHSP74_HUMANBioGRID19940151 details
EPAS1_HUMANETS1_HUMANBioGRID12464608 details
EPAS1_HUMANMITF_HUMANBioGRID23275444 details
EPAS1_HUMANSOX10_HUMANBioGRID23275444 details
EPAS1_HUMANAP2A_HUMANBioGRID23275444 details
EPAS1_HUMANCBP_HUMANBioGRID23275444 25689462 details
EPAS1_HUMANSQSTM_HUMANBioGRID24998849 details
EPAS1_HUMANLAMP1_HUMANBioGRID24998849 details
EPAS1_HUMANMLP3A_HUMANBioGRID24998849 details
EPAS1_HUMANHIF3A_HUMANBioGRID17998805 details
EPAS1_HUMANIKKB_HUMANBioGRID26500060 details
EPAS1_HUMANMYBB_HUMANBioGRID28394947 details
EPAS1_HUMANCR3L1_HUMANBioGRID26558437 details
EPAS1_HUMANUSF2_HUMANBioGRID23991099 details
EPAS1_HUMANGCR_HUMANBioGRID26825173 details
EPAS1_HUMANELK1_HUMANBioGRID16740701 details
EPAS1_HUMANICAM1_HUMANBioGRID25879517 details
EPAS1_HUMANKLF6_HUMANBioGRID25879517 details
EPAS1_HUMANPTK6_HUMANBioGRID23928995 details
EPAS1_HUMANTET1_HUMANBioGRID25517638 details
EPAS1_HUMANWDR5_HUMANBioGRID25517638 details
EPAS1_HUMANOTU7B_HUMANBioGRID32461361 details
EPAS1_HUMANUBP29_HUMANBioGRID32461361 details
EPAS1_HUMANSNUT2_HUMANBioGRID32461361 details
EPAS1_HUMANUBP37_HUMANBioGRID32461361 details
EPAS1_HUMANKPCD1_HUMANHPRD17024177 details