Entity Details

Primary name MUSK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15146
EntryNameMUSK_HUMAN
FullNameMuscle, skeletal receptor tyrosine-protein kinase
TaxID9606
Evidenceevidence at protein level
Length869
SequenceStatuscomplete
DateCreated2004-07-19
DateModified2021-06-02

Ontological Relatives

GenesMUSK

GO terms

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GOName
GO:0001934 positive regulation of protein phosphorylation
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005518 collagen binding
GO:0005524 ATP binding
GO:0005887 integral component of plasma membrane
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007528 neuromuscular junction development
GO:0007613 memory
GO:0008582 regulation of synaptic assembly at neuromuscular junction
GO:0010628 positive regulation of gene expression
GO:0030154 cell differentiation
GO:0031594 neuromuscular junction
GO:0033674 positive regulation of kinase activity
GO:0038062 protein tyrosine kinase collagen receptor activity
GO:0043235 receptor complex
GO:0045211 postsynaptic membrane
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0071340 skeletal muscle acetylcholine-gated channel clustering
GO:2000541 positive regulation of protein geranylgeranylation

Subcellular Location

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Subcellular Location
Cell junction

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013098 Immunoglobulin I-setDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020067 Frizzled domainDomainDomain
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR036790 Frizzled cysteine-rich domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule