Entity Details

Primary name TLR8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NR97
EntryNameTLR8_HUMAN
FullNameToll-like receptor 8
TaxID9606
Evidenceevidence at protein level
Length1041
SequenceStatuscomplete
DateCreated2002-01-31
DateModified2021-06-02

Ontological Relatives

GenesTLR8

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001932 regulation of protein phosphorylation
GO:0002224 toll-like receptor signaling pathway
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0003727 single-stranded RNA binding
GO:0004888 transmembrane signaling receptor activity
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0009615 response to virus
GO:0009897 external side of plasma membrane
GO:0010008 endosome membrane
GO:0016021 integral component of membrane
GO:0016064 immunoglobulin mediated immune response
GO:0032695 negative regulation of interleukin-12 production
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0032729 positive regulation of interferon-gamma production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0034158 toll-like receptor 8 signaling pathway
GO:0036020 endolysosome membrane
GO:0038023 signaling receptor activity
GO:0038187 pattern recognition receptor activity
GO:0042802 identical protein binding
GO:0045087 innate immune response
GO:0045089 positive regulation of innate immune response
GO:0051607 defense response to virus
GO:0071260 cellular response to mechanical stimulus

Subcellular Location

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Subcellular Location
Endosome membrane

Domains

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DomainNameCategoryType
IPR000157 Toll/interleukin-1 receptor homology (TIR) domainDomainDomain
IPR000483 Cysteine-rich flanking region, C-terminalDomainDomain
IPR001611 Leucine-rich repeatRepeatRepeat
IPR003591 Leucine-rich repeat, typical subtypeRepeatRepeat
IPR027175 Toll-like receptor 8FamilyFamily
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00724 ImiquimodDrugbanksmall molecule
DB06530 ResiquimodDrugbanksmall molecule