Entity Details

Primary name EPM2A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95278
EntryNameEPM2A_HUMAN
FullNameLaforin
TaxID9606
Evidenceevidence at protein level
Length331
SequenceStatuscomplete
DateCreated2004-07-19
DateModified2021-06-02

Ontological Relatives

GenesEPM2A

GO terms

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GOName
GO:0000045 autophagosome assembly
GO:0001558 regulation of cell growth
GO:0004373 glycogen (starch) synthase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005977 glycogen metabolic process
GO:0005978 glycogen biosynthetic process
GO:0006470 protein dephosphorylation
GO:0006816 calcium ion transport
GO:0007005 mitochondrion organization
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0010629 negative regulation of gene expression
GO:0010923 negative regulation of phosphatase activity
GO:0014009 glial cell proliferation
GO:0015813 L-glutamate transmembrane transport
GO:0016055 Wnt signaling pathway
GO:0016239 positive regulation of macroautophagy
GO:0016311 dephosphorylation
GO:0016791 phosphatase activity
GO:0019203 carbohydrate phosphatase activity
GO:0030246 carbohydrate binding
GO:0030425 dendrite
GO:0031396 regulation of protein ubiquitination
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0035305 negative regulation of dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0042306 regulation of protein import into nucleus
GO:0042803 protein homodimerization activity
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043204 perikaryon
GO:0045786 negative regulation of cell cycle
GO:0045859 regulation of protein kinase activity
GO:0046835 carbohydrate phosphorylation
GO:0046838 phosphorylated carbohydrate dephosphorylation
GO:0046959 habituation
GO:0046983 protein dimerization activity
GO:0061136 regulation of proteasomal protein catabolic process
GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane
GO:0106306 protein serine phosphatase activity
GO:0106307 protein threonine phosphatase activity
GO:1903076 regulation of protein localization to plasma membrane
GO:1904666 regulation of ubiquitin protein ligase activity
GO:2000465 regulation of glycogen (starch) synthase activity
GO:2001069 glycogen binding
GO:2001070 starch binding

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Endoplasmic reticulum membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000387 Tyrosine specific protein phosphatases domainDomainDomain
IPR002044 Carbohydrate binding module family 20DomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR013784 Carbohydrate-binding-like foldFamilyHomologous superfamily
IPR016130 Protein-tyrosine phosphatase, active siteSiteActive site
IPR020422 Dual specificity protein phosphatase domainDomainDomain
IPR029021 Protein-tyrosine phosphatase-likeFamilyHomologous superfamily
IPR034831 Laforin, CBM20 domainDomainDomain
IPR042942 LaforinFamilyFamily

Diseases

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Interactions

29 interactions

InteractorPartnerSourcesPublicationsLink
EPM2A_HUMANEPM2A_HUMANBioGRID, IntAct14532330 18617530 23922729 26493215 30041081 details
EPM2A_HUMANPPR3C_HUMANBioGRID, IntAct14532330 18070875 26493215 30041081 details
EPM2A_HUMANNHLC1_HUMANBioGRID, UniProt15930137 16115820 18029386 18617530 21505799 22578008 23922729 26546463 26648032 30041081 31758957 details
EPM2A_HUMANAAKB2_HUMANBioGRID, IntAct18029386 28514442 details
EPM2A_HUMANCCKN_HUMANIntAct32814053 details
EPM2A_HUMANLAMP2_HUMANIntAct32814053 details
EPM2A_HUMANSHLB1_HUMANIntAct32814053 details
EPM2A_HUMANNFU1_HUMANBioGRID, HPRD12915448 details
EPM2A_HUMANGSK3B_HUMANBioGRID16115820 details
EPM2A_HUMANAAPK2_HUMANBioGRID18029386 details
EPM2A_HUMANAAPK1_HUMANBioGRID21728993 details
EPM2A_HUMANPPR3D_HUMANBioGRID23624058 30041081 details
EPM2A_HUMANSRPK2_HUMANBioGRID26167880 details
EPM2A_HUMANKPYM_HUMANBioGRID26493215 details
EPM2A_HUMANTOPRS_HUMANBioGRID26493215 details
EPM2A_HUMANCOX5A_HUMANBioGRID26493215 details
EPM2A_HUMANTDG_HUMANBioGRID26493215 details
EPM2A_HUMANPRS6A_HUMANBioGRID26493215 details
EPM2A_HUMANHMGX4_HUMANBioGRID26493215 details
EPM2A_HUMANEI2BA_HUMANBioGRID26493215 details
EPM2A_HUMANGYS1_HUMANIntAct14532330 details
EPM2A_HUMANCHIP_HUMANBioGRID21652633 details
EPM2A_HUMANUBE2N_HUMANBioGRID26546463 details
EPM2A_HUMANSQSTM_HUMANBioGRID26546463 details
EPM2A_HUMANATX1_HUMANBioGRID29852174 details
EPM2A_HUMANBECN1_HUMANBioGRID31758957 details
EPM2A_HUMANPI3R4_HUMANBioGRID31758957 details
EPM2A_HUMANPK3C3_HUMANBioGRID31758957 details
EPM2A_HUMANEPMIP_HUMANHPRD12782127 details