Entity Details

Primary name AP2A1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95782
EntryNameAP2A1_HUMAN
FullNameAP-2 complex subunit alpha-1
TaxID9606
Evidenceevidence at protein level
Length977
SequenceStatuscomplete
DateCreated2001-01-24
DateModified2021-06-02

Ontological Relatives

GenesAP2A1

GO terms

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GOName
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006886 intracellular protein transport
GO:0006895 Golgi to endosome transport
GO:0006897 endocytosis
GO:0006898 receptor-mediated endocytosis
GO:0008022 protein C-terminus binding
GO:0010976 positive regulation of neuron projection development
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0019901 protein kinase binding
GO:0030122 AP-2 adaptor complex
GO:0030130 clathrin coat of trans-Golgi network vesicle
GO:0030666 endocytic vesicle membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0032433 filopodium tip
GO:0032802 low-density lipoprotein particle receptor catabolic process
GO:0034383 low-density lipoprotein particle clearance
GO:0035615 clathrin adaptor activity
GO:0036020 endolysosome membrane
GO:0044877 protein-containing complex binding
GO:0045334 clathrin-coated endocytic vesicle
GO:0048013 ephrin receptor signaling pathway
GO:0048260 positive regulation of receptor-mediated endocytosis
GO:0050690 regulation of defense response to virus by virus
GO:0050750 low-density lipoprotein particle receptor binding
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0061024 membrane organization
GO:0072583 clathrin-dependent endocytosis
GO:0140312 cargo adaptor activity
GO:1900126 negative regulation of hyaluronan biosynthetic process

Subcellular Location

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Subcellular Location
Cell membrane
Membrane

Domains

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DomainNameCategoryType
IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminalDomainDomain
IPR003164 Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomainDomainDomain
IPR008152 Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomainDomainDomain
IPR009028 Coatomer/calthrin adaptor appendage, C-terminal subdomainFamilyHomologous superfamily
IPR011989 Armadillo-like helicalFamilyHomologous superfamily
IPR012295 TBP domain superfamilyFamilyHomologous superfamily
IPR013041 Clathrin adaptor, appendage, Ig-like subdomain superfamilyFamilyHomologous superfamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR017104 Adaptor protein complex AP-2, alpha subunitFamilyFamily

Diseases

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Interactions

66 interactions

InteractorPartnerSourcesPublicationsLink
AP2A1_HUMANHIP1_HUMANBioGRID, HPRD, MINT11517213 11532990 details
AP2A1_HUMANSMAD9_HUMANBioGRID, HPRD, MINT15231748 details
AP2A1_HUMANRIT1_HUMANHPRD, IntAct16169070 details
AP2A1_HUMANTOE1_HUMANHPRD, IntAct16169070 details
AP2A1_HUMANNUMB_HUMANBioGRID, HPRD, IntAct, MINT12942088 17203073 23211419 details
AP2A1_HUMANEGFR_HUMANBioGRID, IntAct20029029 23956138 24189400 24797263 25754235 31959764 7534311 details
AP2A1_HUMANDUX4_HUMANBioGRID, IntAct26816005 details
AP2A1_HUMANEPN4_HUMANBioGRID, HPRD, IntAct12429846 28514442 details
AP2A1_HUMANAAGAB_HUMANBioGRID, IntAct26186194 28514442 31353312 details
AP2A1_HUMANAMPH_HUMANBioGRID, IntAct12057195 28514442 details
AP2A1_HUMANAP2S1_HUMANBioGRID, HPRD, IntAct26344197 28514442 31353312 7593184 details
AP2A1_HUMANITSN1_HUMANBioGRID, IntAct28484035 32203420 details
AP2A1_HUMANDPYL2_HUMANBioGRID12942088 details
AP2A1_HUMANEHD1_HUMANBioGRID11423532 details
AP2A1_HUMANNAGPA_HUMANBioGRID, HPRD11723124 details
AP2A1_HUMANSHBG_HUMANBioGRID, HPRD15862967 details
AP2A1_HUMANSYNJ1_HUMANBioGRID12057195 details
AP2A1_HUMANMYO6_HUMANBioGRID11447109 26950368 details
AP2A1_HUMANPIN1_HUMANBioGRID16055720 details
AP2A1_HUMANBIN1_HUMANBioGRID, HPRD9182529 9280305 details
AP2A1_HUMANUBC_HUMANBioGRID28190767 details
AP2A1_HUMANMYC_HUMANBioGRID, IntAct17353931 29467282 details
AP2A1_HUMANRNPS1_HUMANIntAct17353931 details
AP2A1_HUMANTRAF6_HUMANIntAct17353931 details
AP2A1_HUMANSHC1_HUMANBioGRID, HPRD, IntAct11302736 19380743 24189400 28514442 31980649 8617812 details
AP2A1_HUMANEPS15_HUMANBioGRID, HPRD, IntAct10764745 10953014 19380743 8662627 9049247 details
AP2A1_HUMANMLP3A_HUMANBioGRID, IntAct20562859 24067654 details
AP2A1_HUMANFCHO2_HUMANUniProt21762413 details
AP2A1_HUMANATG9A_HUMANBioGRID, MINT24603492 27587839 details
AP2A1_HUMANOCRL_HUMANBioGRID, IntAct, MINT25107275 27173435 28514442 unassigned1312 details
AP2A1_HUMANPICAL_HUMANBioGRID, HPRD, IntAct10436022 22939629 28514442 details
AP2A1_HUMANRBP1_HUMANBioGRID, IntAct10764745 28514442 31980649 details
AP2A1_HUMANDNJC5_HUMANBioGRID, IntAct29997244 details
AP2A1_HUMANH2B2C_HUMANIntAct30021884 details
AP2A1_HUMANL1CAM_HUMANBioGRID12942088 details
AP2A1_HUMANCD22_HUMANBioGRID12646615 details
AP2A1_HUMANRFIP2_HUMANBioGRID, HPRD12364336 details
AP2A1_HUMANBRCA1_HUMANBioGRID21880590 details
AP2A1_HUMANREPS2_HUMANBioGRID10764745 details
AP2A1_HUMANEPN1_HUMANBioGRID, HPRD10764745 9723620 details
AP2A1_HUMANDAB2_HUMANBioGRID22323290 details
AP2A1_HUMANITA4_HUMANBioGRID22623428 details
AP2A1_HUMANARRB1_HUMANBioGRID16709866 details
AP2A1_HUMANRNF11_HUMANBioGRID23751493 details
AP2A1_HUMANABCBB_HUMANBioGRID22262466 details
AP2A1_HUMANEPHA2_HUMANBioGRID23874206 details
AP2A1_HUMANMEX3C_HUMANBioGRID26471122 28982131 32460013 details
AP2A1_HUMANUTP25_HUMANBioGRID26472760 details
AP2A1_HUMANARF6_HUMANBioGRID16413285 details
AP2A1_HUMANDVL2_HUMANBioGRID31340145 details
AP2A1_HUMANMEX3B_HUMANBioGRID29395067 details
AP2A1_HUMANPATL1_HUMANBioGRID29395067 details
AP2A1_HUMANSMAP2_HUMANBioGRID29395067 details
AP2A1_HUMANTNR6A_HUMANBioGRID29395067 details
AP2A1_HUMANTNR6B_HUMANBioGRID29395067 details
AP2A1_HUMANTNR6C_HUMANBioGRID29395067 details
AP2A1_HUMANDDX3X_HUMANBioGRID29395067 details
AP2A1_HUMANEST1A_HUMANBioGRID29395067 details
AP2A1_HUMANSMG7_HUMANBioGRID29395067 details
AP2A1_HUMANISG15_HUMANBioGRID33024031 details
AP2A1_HUMANGHR_HUMANHPRD10551776 details
AP2A1_HUMANSYT3_HUMANHPRD7791877 details
AP2A1_HUMANSYT7_HUMANHPRD7791877 details
AP2A1_HUMANSNP29_HUMANHPRD11423532 details
AP2A1_HUMANDEK_HUMANHPRD12595566 details
AP2A1_HUMANDYN2_HUMANHPRD16696976 details