Entity Details

Primary name IFNG_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01579
EntryNameIFNG_HUMAN
FullNameInterferon gamma
TaxID9606
Evidenceevidence at protein level
Length166
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesIFNG

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001774 microglial cell activation
GO:0001819 positive regulation of cytokine production
GO:0001934 positive regulation of protein phosphorylation
GO:0002250 adaptive immune response
GO:0002281 macrophage activation involved in immune response
GO:0005125 cytokine activity
GO:0005133 interferon-gamma receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006915 apoptotic process
GO:0006959 humoral immune response
GO:0007166 cell surface receptor signaling pathway
GO:0007259 receptor signaling pathway via JAK-STAT
GO:0008284 positive regulation of cell population proliferation
GO:0009615 response to virus
GO:0010508 positive regulation of autophagy
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010634 positive regulation of epithelial cell migration
GO:0010835 regulation of protein ADP-ribosylation
GO:0030225 macrophage differentiation
GO:0030857 negative regulation of epithelial cell differentiation
GO:0031334 positive regulation of protein-containing complex assembly
GO:0032700 negative regulation of interleukin-17 production
GO:0032722 positive regulation of chemokine production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032735 positive regulation of interleukin-12 production
GO:0032747 positive regulation of interleukin-23 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032834 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0034393 positive regulation of smooth muscle cell apoptotic process
GO:0035722 interleukin-12-mediated signaling pathway
GO:0040008 regulation of growth
GO:0042307 positive regulation of protein import into nucleus
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0045348 positive regulation of MHC class II biosynthetic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045589 regulation of regulatory T cell differentiation
GO:0045672 positive regulation of osteoclast differentiation
GO:0045821 positive regulation of glycolytic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048143 astrocyte activation
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050729 positive regulation of inflammatory response
GO:0050766 positive regulation of phagocytosis
GO:0050769 positive regulation of neurogenesis
GO:0050796 regulation of insulin secretion
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0051173 positive regulation of nitrogen compound metabolic process
GO:0051607 defense response to virus
GO:0051712 positive regulation of killing of cells of other organism
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
GO:0060550 positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity
GO:0060552 positive regulation of fructose 1,6-bisphosphate metabolic process
GO:0060557 positive regulation of vitamin D biosynthetic process
GO:0060559 positive regulation of calcidiol 1-monooxygenase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0090312 positive regulation of protein deacetylation
GO:0097191 extrinsic apoptotic signaling pathway
GO:0150076 neuroinflammatory response
GO:1900222 negative regulation of amyloid-beta clearance
GO:1901216 positive regulation of neuron death
GO:1901857 positive regulation of cellular respiration
GO:1902004 positive regulation of amyloid-beta formation
GO:1902948 negative regulation of tau-protein kinase activity
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1903543 positive regulation of exosomal secretion
GO:1904440 positive regulation of iron ion import across plasma membrane
GO:1904783 positive regulation of NMDA glutamate receptor activity
GO:1904798 positive regulation of core promoter binding
GO:2000273 positive regulation of signaling receptor activity
GO:2000309 positive regulation of tumor necrosis factor (ligand) superfamily member 11 production

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR002069 Interferon gammaFamilyFamily
IPR009079 Four-helical cytokine-like, coreFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01250 OlsalazineDrugbanksmall molecule
DB01296 GlucosamineDrugbanksmall molecule
DB05110 VIR201Drugbankbiotech
DB05111 FontolizumabDrugbankbiotech
DB10770 Foreskin fibroblast (neonatal)Drugbankbiotech
DB10772 Foreskin keratinocyte (neonatal)Drugbankbiotech
DB14724 EmapalumabDrugbankbiotech