Entity Details

Primary name APOA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP02647
EntryNameAPOA1_HUMAN
FullNameApolipoprotein A-I
TaxID9606
Evidenceevidence at protein level
Length267
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesAPOA1

GO terms

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GOName
GO:0006869 lipid transport
GO:0043687 post-translational protein modification
GO:0007186 G protein-coupled receptor signaling pathway
GO:0035025 positive regulation of Rho protein signal transduction
GO:0042157 lipoprotein metabolic process
GO:0051006 positive regulation of lipoprotein lipase activity
GO:0060354 negative regulation of cell adhesion molecule production
GO:1903561 extracellular vesicle
GO:0001540 amyloid-beta binding
GO:0002719 negative regulation of cytokine production involved in immune response
GO:0005102 signaling receptor binding
GO:0005576 extracellular region
GO:0005769 early endosome
GO:0006695 cholesterol biosynthetic process
GO:0032691 negative regulation of interleukin-1 beta production
GO:0008211 glucocorticoid metabolic process
GO:0034364 high-density lipoprotein particle
GO:0034378 chylomicron assembly
GO:0050821 protein stabilization
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0014012 peripheral nervous system axon regeneration
GO:0034362 low-density lipoprotein particle
GO:0034371 chylomicron remodeling
GO:0060761 negative regulation of response to cytokine stimulus
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:0001523 retinoid metabolic process
GO:0005634 nucleus
GO:0008035 high-density lipoprotein particle binding
GO:0030301 cholesterol transport
GO:0031100 animal organ regeneration
GO:0031210 phosphatidylcholine binding
GO:0034366 spherical high-density lipoprotein particle
GO:0009986 cell surface
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0034372 very-low-density lipoprotein particle remodeling
GO:0046470 phosphatidylcholine metabolic process
GO:0050728 negative regulation of inflammatory response
GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity
GO:1902995 positive regulation of phospholipid efflux
GO:0034115 negative regulation of heterotypic cell-cell adhesion
GO:0050766 positive regulation of phagocytosis
GO:0051180 vitamin transport
GO:0070062 extracellular exosome
GO:0030325 adrenal gland development
GO:0034190 apolipoprotein receptor binding
GO:0034361 very-low-density lipoprotein particle
GO:0051345 positive regulation of hydrolase activity
GO:0015485 cholesterol binding
GO:0043691 reverse cholesterol transport
GO:0002576 platelet degranulation
GO:0010875 positive regulation of cholesterol efflux
GO:0010898 positive regulation of triglyceride catabolic process
GO:0031410 cytoplasmic vesicle
GO:0032489 regulation of Cdc42 protein signal transduction
GO:0033344 cholesterol efflux
GO:0033700 phospholipid efflux
GO:0034365 discoidal high-density lipoprotein particle
GO:0062023 collagen-containing extracellular matrix
GO:0034774 secretory granule lumen
GO:0060192 negative regulation of lipase activity
GO:0005829 cytosol
GO:0031072 heat shock protein binding
GO:0043627 response to estrogen
GO:0007229 integrin-mediated signaling pathway
GO:0019899 enzyme binding
GO:0034375 high-density lipoprotein particle remodeling
GO:0042632 cholesterol homeostasis
GO:0019222 regulation of metabolic process
GO:0050919 negative chemotaxis
GO:0070328 triglyceride homeostasis
GO:0072562 blood microparticle
GO:1990000 amyloid fibril formation
GO:0005788 endoplasmic reticulum lumen
GO:0030139 endocytic vesicle
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0055102 lipase inhibitor activity
GO:0070653 high-density lipoprotein particle receptor binding
GO:0071682 endocytic vesicle lumen
GO:0018158 protein oxidation
GO:0046889 positive regulation of lipid biosynthetic process
GO:0120020 cholesterol transfer activity
GO:0019915 lipid storage
GO:0045499 chemorepellent activity
GO:0001932 regulation of protein phosphorylation
GO:0007584 response to nutrient
GO:0034363 intermediate-density lipoprotein particle
GO:0044267 cellular protein metabolic process
GO:0001935 endothelial cell proliferation
GO:0006898 receptor-mediated endocytosis
GO:0042627 chylomicron
GO:0043534 blood vessel endothelial cell migration
GO:0051496 positive regulation of stress fiber assembly
GO:0006656 phosphatidylcholine biosynthetic process
GO:0010873 positive regulation of cholesterol esterification
GO:0018206 peptidyl-methionine modification
GO:0042158 lipoprotein biosynthetic process
GO:0055091 phospholipid homeostasis
GO:0034380 high-density lipoprotein particle assembly
GO:0045723 positive regulation of fatty acid biosynthetic process
GO:0070508 cholesterol import
GO:0005543 phospholipid binding
GO:0008203 cholesterol metabolic process
GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling
GO:0030300 regulation of intestinal cholesterol absorption
GO:0034191 apolipoprotein A-I receptor binding
GO:0034384 high-density lipoprotein particle clearance

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000074 Apolipoprotein A/EFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB01593 ZincDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

51 interactions

InteractorPartnerSourcesPublicationsLink
APOA1_HUMANMA7D1_HUMANBioGRID, HPRD, IntAct16169070 details
APOA1_HUMANTR10C_HUMANBioGRID, HPRD, IntAct16169070 details
APOA1_HUMANTOM20_HUMANBioGRID, HPRD, IntAct16169070 details
APOA1_HUMANPIMT_HUMANHPRD, IntAct16169070 details
APOA1_HUMANA4_HUMANBioGRID, IntAct11297421 21832049 32814053 7802646 details
APOA1_HUMANAPOC1_HUMANBioGRID, IntAct11991719 15174051 details
APOA1_HUMANCLC4G_HUMANBioGRID, IntAct18624398 details
APOA1_HUMANHPT_HUMANBioGRID, MINT15533931 19758344 24981860 details
APOA1_HUMANFBLN1_HUMANBioGRID, IntAct21988832 details
APOA1_HUMANRPA12_HUMANBioGRID, IntAct21988832 details
APOA1_HUMANAKT2_HUMANBioGRID, IntAct21988832 details
APOA1_HUMANJAK3_HUMANBioGRID, IntAct21988832 details
APOA1_HUMANOSTP_HUMANBioGRID, IntAct21988832 details
APOA1_HUMANMK06_HUMANBioGRID, IntAct, MINT21900206 28514442 details
APOA1_HUMANAPOA1_HUMANBioGRID, DIP, HPRD, IntAct, MINT11744719 15174051 17676061 18719128 20133843 20884842 22184756 22609356 24316228 24702826 8810909 9003180 9200714 9356442 details
APOA1_HUMANSCRB1_HUMANbhf-ucl, BioGRID, HPRD1076467 10764676 details
APOA1_HUMANABCA1_HUMANbhf-ucl, BioGRID, HPRD, IntAct12084722 27017521 30458687 details
APOA1_HUMANLCAT_HUMANbhf-ucl, BioGRID, DIP, HPRD10026251 10222237 15654758 1587806 1644835 17676061 3104518 4335615 details
APOA1_HUMANCKLF5_HUMANBioGRID, IntAct25416956 25910212 32296183 details
APOA1_HUMANBRAP_HUMANBioGRID, IntAct25820252 details
APOA1_HUMANLAMP2_HUMANIntAct32814053 details
APOA1_HUMANSHLB1_HUMANIntAct32814053 details
APOA1_HUMANPDE1A_HUMANBioGRID, HPRD11991719 details
APOA1_HUMANPLTP_HUMANBioGRID, HPRD11854286 9469594 details
APOA1_HUMANPHLD_HUMANBioGRID, HPRD11254757 details
APOA1_HUMANSAA2_HUMANBioGRID11991719 details
APOA1_HUMANNNRE_HUMANBioGRID, HPRD11991719 details
APOA1_HUMANABCAD_HUMANBioGRID11162594 details
APOA1_HUMANVKOR1_HUMANBioGRID21103663 details
APOA1_HUMANAPOA2_HUMANBioGRID10722751 24981860 3104518 details
APOA1_HUMANNDRG1_HUMANBioGRID15922294 details
APOA1_HUMANTREM2_HUMANBioGRID27477018 details
APOA1_HUMANHS90A_HUMANBioGRID31273033 details
APOA1_HUMANTTHY_HUMANBioGRID, HPRD, IntAct10627502 15174051 details
APOA1_HUMANSYUA_HUMANBioGRID, IntAct28887769 31270237 details
APOA1_HUMANC1QBP_HUMANIntAct28565870 details
APOA1_HUMANAPOB_HUMANBioGRID, HPRD, IntAct19164805 28183703 7592581 details
APOA1_HUMANAPOL1_HUMANBioGRID9325276 details
APOA1_HUMANAPOF_HUMANBioGRID, HPRD6816269 details
APOA1_HUMANLBP_HUMANBioGRID, HPRD8663389 details
APOA1_HUMANCD40L_HUMANBioGRID10085035 details
APOA1_HUMANTERA_HUMANBioGRID19164805 details
APOA1_HUMANDGAT1_HUMANBioGRID3104518 details
APOA1_HUMANAPOD_HUMANBioGRID3104518 details
APOA1_HUMANATP4A_HUMANBioGRID17255364 details
APOA1_HUMANU2AF2_HUMANBioGRID26641092 details
APOA1_HUMANCETP_HUMANHPRD9305883 details
APOA1_HUMANPON1_HUMANHPRD16128586 details
APOA1_HUMANFHR1_HUMANHPRD8663389 details
APOA1_HUMANATPB_HUMANHPRD2687158 details
APOA1_HUMANHPTR_HUMANHPRD10085035 details