Entity Details

Primary name HG2A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP04233
EntryNameHG2A_HUMAN
FullNameHLA class II histocompatibility antigen gamma chain
TaxID9606
Evidenceevidence at protein level
Length296
SequenceStatuscomplete
DateCreated1987-03-20
DateModified2021-06-02

Ontological Relatives

GenesCD74

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0000187 obsolete activation of MAPK activity
GO:0001516 prostaglandin biosynthetic process
GO:0001540 amyloid-beta binding
GO:0001934 positive regulation of protein phosphorylation
GO:0001961 positive regulation of cytokine-mediated signaling pathway
GO:0002286 T cell activation involved in immune response
GO:0002606 positive regulation of dendritic cell antigen processing and presentation
GO:0002792 negative regulation of peptide secretion
GO:0002830 positive regulation of type 2 immune response
GO:0002906 negative regulation of mature B cell apoptotic process
GO:0004896 cytokine receptor activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005770 late endosome
GO:0005771 multivesicular body
GO:0005773 vacuole
GO:0005886 plasma membrane
GO:0006886 intracellular protein transport
GO:0008283 cell population proliferation
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010628 positive regulation of gene expression
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016064 immunoglobulin mediated immune response
GO:0019882 antigen processing and presentation
GO:0019883 antigen processing and presentation of endogenous antigen
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0019955 cytokine binding
GO:0023026 MHC class II protein complex binding
GO:0030336 negative regulation of cell migration
GO:0030658 transport vesicle membrane
GO:0030666 endocytic vesicle membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0030890 positive regulation of B cell proliferation
GO:0031394 positive regulation of prostaglandin biosynthetic process
GO:0032588 trans-Golgi network membrane
GO:0032722 positive regulation of chemokine production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032991 protein-containing complex
GO:0033674 positive regulation of kinase activity
GO:0034341 response to interferon-gamma
GO:0035691 macrophage migration inhibitory factor signaling pathway
GO:0035692 macrophage migration inhibitory factor receptor complex
GO:0035693 NOS2-CD74 complex
GO:0035718 macrophage migration inhibitory factor binding
GO:0042289 MHC class II protein binding
GO:0042609 CD4 receptor binding
GO:0042613 MHC class II protein complex
GO:0042658 MHC class II protein binding, via antigen binding groove
GO:0042802 identical protein binding
GO:0043030 regulation of macrophage activation
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043202 lysosomal lumen
GO:0043410 positive regulation of MAPK cascade
GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0044183 protein folding chaperone
GO:0045058 T cell selection
GO:0045059 positive thymic T cell selection
GO:0045060 negative thymic T cell selection
GO:0045581 negative regulation of T cell differentiation
GO:0045582 positive regulation of T cell differentiation
GO:0045657 positive regulation of monocyte differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046597 negative regulation of viral entry into host cell
GO:0046598 positive regulation of viral entry into host cell
GO:0048146 positive regulation of fibroblast proliferation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050821 protein stabilization
GO:0050900 leukocyte migration
GO:0050998 nitric-oxide synthase binding
GO:0051085 chaperone cofactor-dependent protein refolding
GO:0060907 positive regulation of macrophage cytokine production
GO:0065003 protein-containing complex assembly
GO:0070062 extracellular exosome
GO:0070206 protein trimerization
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
GO:0090023 positive regulation of neutrophil chemotaxis
GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production
GO:2000448 positive regulation of macrophage migration inhibitory factor signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Endoplasmic reticulum membrane
Endosome
Golgi apparatus
Late endosome
Lysosome

Domains

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DomainNameCategoryType
IPR000716 Thyroglobulin type-1DomainDomain
IPR011988 MHC class II-associated invariant chain, trimerisationDomainDomain
IPR015386 MHC class II-associated invariant chain/CLIP, MHC II-interactingDomainDomain
IPR022339 MHC class II-associated invariant chainFamilyFamily
IPR036613 MHC class II-associated invariant chain, trimerisation domain superfamilyFamilyHomologous superfamily
IPR036857 Thyroglobulin type-1 superfamilyFamilyHomologous superfamily
IPR043530 HLA class II histocompatibility antigen, gamma subunitFamilyFamily

Diseases

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Interactions

50 interactions

InteractorPartnerSourcesPublicationsLink
HG2A_HUMANECHA_HUMANBioGRID, IntAct21988832 30833792 details
HG2A_HUMANTEX11_HUMANBioGRID, IntAct32296183 details
HG2A_HUMANSMIM1_HUMANBioGRID, IntAct32296183 details
HG2A_HUMANPMGT1_HUMANBioGRID, IntAct32296183 details
HG2A_HUMANFXYD6_HUMANBioGRID, IntAct32296183 details
HG2A_HUMANT120B_HUMANBioGRID, IntAct32296183 details
HG2A_HUMANSC22A_HUMANBioGRID, IntAct32296183 details
HG2A_HUMANRTP2_HUMANBioGRID, IntAct32296183 details
HG2A_HUMANEP3B_HUMANBioGRID, IntAct32296183 details
HG2A_HUMANFDFT_HUMANBioGRID, IntAct32296183 details
HG2A_HUMANCLD19_HUMANBioGRID, IntAct32296183 details
HG2A_HUMANLPAR3_HUMANBioGRID, IntAct32296183 details
HG2A_HUMANCLC7A_HUMANBioGRID, IntAct32296183 details
HG2A_HUMANS35B1_HUMANBioGRID, IntAct32296183 details
HG2A_HUMANPEPA4_HUMANBioGRID, IntAct32296183 details
HG2A_HUMANCKLF7_HUMANBioGRID, IntAct32296183 details
HG2A_HUMANSGMR2_HUMANBioGRID, IntAct32296183 details
HG2A_HUMANNRAC_HUMANBioGRID, IntAct32296183 details
HG2A_HUMANTM254_HUMANBioGRID, IntAct32296183 details
HG2A_HUMANUPK2_HUMANBioGRID, IntAct32296183 details
HG2A_HUMANPTC1_HUMANBioGRID, IntAct32296183 details
HG2A_HUMANERG28_HUMANBioGRID, IntAct32296183 details
HG2A_HUMANPLPP4_HUMANBioGRID, IntAct32296183 details
HG2A_HUMANSERP1_HUMANBioGRID, IntAct32296183 details
HG2A_HUMANMYPR_HUMANBioGRID, IntAct32296183 details
HG2A_HUMANTMM60_HUMANBioGRID, IntAct32296183 details
HG2A_HUMANBET1_HUMANBioGRID, IntAct32296183 details
HG2A_HUMANTM243_HUMANBioGRID, IntAct32296183 details
HG2A_HUMANHS71A_HUMANIntAct17357109 24428437 details
HG2A_HUMANCD44_HUMANBioGRID, HPRD, IntAct27872288 29190904 8343954 details
HG2A_HUMANCCR1_HUMANBioGRID, MINT28298427 details
HG2A_HUMANALG3_HUMANUniProt29547901 details
HG2A_HUMANMIF_HUMANBioGRID, HPRD12782713 details
HG2A_HUMANA4_HUMANBioGRID21832049 details
HG2A_HUMANLTOR5_HUMANBioGRID23241634 details
HG2A_HUMANM3K1_HUMANBioGRID25260751 details
HG2A_HUMANDRA_HUMANHPRD, MINT16242130 details
HG2A_HUMANDPA1_HUMANHPRD, MINT16242130 details
HG2A_HUMANDQA1_HUMANBioGRID, HPRD, IntAct, MINT16242130 25241761 details
HG2A_HUMANCXCR4_HUMANMINT19665027 details
HG2A_HUMANDQB1_HUMANHPRD, IntAct16242130 17629515 details
HG2A_HUMANIMB1_HUMANBioGRID, IntAct30833792 details
HG2A_HUMANEIF3E_HUMANBioGRID, IntAct30833792 details
HG2A_HUMANDPB1_HUMANBioGRID, HPRD, IntAct16242130 26186194 30833792 details
HG2A_HUMANCXCR2_HUMANIntAct17435771 details
HG2A_HUMANHG2A_HUMANBioGRID, HPRD2391366 9752000 9843486 details
HG2A_HUMANCATL1_HUMANHPRD10022822 details
HG2A_HUMANDMB_HUMANHPRD8574855 details
HG2A_HUMANCD1D_HUMANHPRD11754812 details
HG2A_HUMANCATF_HUMANHPRD10748235 details