Entity Details

Primary name ARGI1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP05089
EntryNameARGI1_HUMAN
FullNameArginase-1
TaxID9606
Evidenceevidence at protein level
Length322
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesARG1

GO terms

Show/Hide Table
GOName
GO:0000050 urea cycle
GO:0001889 liver development
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002250 adaptive immune response
GO:0004053 arginase activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0006527 arginine catabolic process
GO:0007568 aging
GO:0009635 response to herbicide
GO:0010042 response to manganese ion
GO:0010043 response to zinc ion
GO:0010269 response to selenium ion
GO:0010963 regulation of L-arginine import
GO:0014075 response to amine
GO:0019547 arginine catabolic process to ornithine
GO:0030145 manganese ion binding
GO:0030324 lung development
GO:0032964 collagen biosynthetic process
GO:0033189 response to vitamin A
GO:0033197 response to vitamin E
GO:0035578 azurophil granule lumen
GO:0035580 specific granule lumen
GO:0042130 negative regulation of T cell proliferation
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0042832 defense response to protozoan
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043200 response to amino acid
GO:0043312 neutrophil degranulation
GO:0045087 innate immune response
GO:0046007 negative regulation of activated T cell proliferation
GO:0046686 response to cadmium ion
GO:0048678 response to axon injury
GO:0051597 response to methylmercury
GO:0060056 mammary gland involution
GO:0060135 maternal process involved in female pregnancy
GO:0060336 negative regulation of interferon-gamma-mediated signaling pathway
GO:0070301 cellular response to hydrogen peroxide
GO:0070965 positive regulation of neutrophil mediated killing of fungus
GO:0071222 cellular response to lipopolysaccharide
GO:0071353 cellular response to interleukin-4
GO:0071377 cellular response to glucagon stimulus
GO:0071549 cellular response to dexamethasone stimulus
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:2000552 negative regulation of T-helper 2 cell cytokine production

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Cytoplasmic granule

Domains

Show/Hide Table
DomainNameCategoryType
IPR006035 UreohydrolaseFamilyFamily
IPR014033 ArginaseFamilyFamily
IPR020855 Ureohydrolase, manganese-binding siteSiteBinding site
IPR023696 Ureohydrolase domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00129 OrnithineDrugbanksmall molecule
DB01983 2(S)-Amino-6-Boronohexanoic AcidDrugbanksmall molecule
DB02381 nor-NOHADrugbanksmall molecule
DB02499 Dinor-N(Omega)-Hydroxy-L-ArginineDrugbanksmall molecule
DB02689 S-{2-[Amino(Dihydroxy)-Lambda~4~-Sulfanyl]Ethyl}-D-CysteineDrugbanksmall molecule
DB03144 N(5)-[(hydroxyamino)(imino)methyl]-L-ornithineDrugbanksmall molecule
DB03731 S-2-(Boronoethyl)-L-CysteineDrugbanksmall molecule
DB03904 UreaDrugbanksmall molecule
DB04197 Descarboxy-nor-N(Omega)-Hydroxy-L-ArginineDrugbanksmall molecule
DB04530 S,S-(2-Hydroxyethyl)ThiocysteineDrugbanksmall molecule
DB04585 DEHYDRO-2(S)-AMINO-6-BORONOHEXANOIC ACIDDrugbanksmall molecule
DB04648 S-propylamine-L-cysteineDrugbanksmall molecule
DB06757 ManganeseDrugbanksmall molecule