Entity Details

Primary name CP1A2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP05177
EntryNameCP1A2_HUMAN
FullNameCytochrome P450 1A2
TaxID9606
Evidenceevidence at protein level
Length516
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesCYP1A2

GO terms

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GOName
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0005789 endoplasmic reticulum membrane
GO:0006706 steroid catabolic process
GO:0006778 porphyrin-containing compound metabolic process
GO:0006805 xenobiotic metabolic process
GO:0008203 cholesterol metabolic process
GO:0008210 estrogen metabolic process
GO:0009055 electron transfer activity
GO:0009403 toxin biosynthetic process
GO:0009791 post-embryonic development
GO:0009820 alkaloid metabolic process
GO:0010468 regulation of gene expression
GO:0016098 monoterpenoid metabolic process
GO:0016491 oxidoreductase activity
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0017144 drug metabolic process
GO:0018894 dibenzo-p-dioxin metabolic process
GO:0019373 epoxygenase P450 pathway
GO:0019899 enzyme binding
GO:0020037 heme binding
GO:0030324 lung development
GO:0032259 methylation
GO:0032355 response to estradiol
GO:0032451 demethylase activity
GO:0032496 response to lipopolysaccharide
GO:0032787 monocarboxylic acid metabolic process
GO:0034875 caffeine oxidase activity
GO:0035902 response to immobilization stress
GO:0042572 retinol metabolic process
GO:0042737 drug catabolic process
GO:0042738 exogenous drug catabolic process
GO:0042759 long-chain fatty acid biosynthetic process
GO:0043231 intracellular membrane-bounded organelle
GO:0045333 cellular respiration
GO:0046222 aflatoxin metabolic process
GO:0046483 heterocycle metabolic process
GO:0050665 hydrogen peroxide biosynthetic process
GO:0070330 aromatase activity
GO:0070989 oxidative demethylation
GO:0071276 cellular response to cadmium ion
GO:0071280 cellular response to copper ion
GO:0097267 omega-hydroxylase P450 pathway
GO:0101020 estrogen 16-alpha-hydroxylase activity
GO:0101021 estrogen 2-hydroxylase activity
GO:0106256 hydroperoxy icosatetraenoate dehydratase activity

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Microsome membrane

Domains

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DomainNameCategoryType
IPR001128 Cytochrome P450FamilyFamily
IPR002401 Cytochrome P450, E-class, group IFamilyFamily
IPR008066 Cytochrome P450, E-class, group I, CYP1FamilyFamily
IPR017972 Cytochrome P450, conserved siteSiteConserved site
IPR036396 Cytochrome P450 superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00008 Peginterferon alfa-2aDrugbankbiotech
DB00011 Interferon alfa-n1Drugbankbiotech
DB00018 Interferon alfa-n3Drugbankbiotech
DB00022 Peginterferon alfa-2bDrugbankbiotech
DB00030 Insulin humanDrugbankbiotech
DB00033 Interferon gamma-1bDrugbankbiotech
DB00034 Interferon alfa-2a, RecombinantDrugbankbiotech
DB00046 Insulin lisproDrugbankbiotech
DB00047 Insulin glargineDrugbankbiotech
DB00060 Interferon beta-1aDrugbankbiotech
DB00068 Interferon beta-1bDrugbankbiotech
DB00069 Interferon alfacon-1Drugbankbiotech
DB00071 Insulin porkDrugbankbiotech
DB00105 Interferon alfa-2bDrugbankbiotech
DB00170 MenadioneDrugbanksmall molecule
DB00176 FluvoxamineDrugbanksmall molecule
DB00184 NicotineDrugbanksmall molecule
DB00188 BortezomibDrugbanksmall molecule
DB00195 BetaxololDrugbanksmall molecule
DB00201 CaffeineDrugbanksmall molecule
DB00208 TiclopidineDrugbanksmall molecule
DB00215 CitalopramDrugbanksmall molecule
DB00218 MoxifloxacinDrugbanksmall molecule
DB00238 NevirapineDrugbanksmall molecule
DB00252 PhenytoinDrugbanksmall molecule
DB00261 AnagrelideDrugbanksmall molecule
DB00268 RopiniroleDrugbanksmall molecule
DB00277 TheophyllineDrugbanksmall molecule
DB00280 DisopyramideDrugbanksmall molecule
DB00281 LidocaineDrugbanksmall molecule
DB00286 Conjugated estrogensDrugbanksmall molecule
DB00296 RopivacaineDrugbanksmall molecule
DB00313 Valproic acidDrugbanksmall molecule
DB00315 ZolmitriptanDrugbanksmall molecule
DB00316 AcetaminophenDrugbanksmall molecule
DB00321 AmitriptylineDrugbanksmall molecule
DB00333 MethadoneDrugbanksmall molecule
DB00334 OlanzapineDrugbanksmall molecule
DB00338 OmeprazoleDrugbanksmall molecule
DB00356 ChlorzoxazoneDrugbanksmall molecule
DB00363 ClozapineDrugbanksmall molecule
DB00365 GrepafloxacinDrugbanksmall molecule
DB00370 MirtazapineDrugbanksmall molecule
DB00377 PalonosetronDrugbanksmall molecule
DB00379 MexiletineDrugbanksmall molecule
DB00382 TacrineDrugbanksmall molecule
DB00384 TriamtereneDrugbanksmall molecule
DB00388 PhenylephrineDrugbanksmall molecule
DB00398 SorafenibDrugbanksmall molecule
DB00400 GriseofulvinDrugbanksmall molecule
DB00409 RemoxiprideDrugbanksmall molecule
DB00412 RosiglitazoneDrugbanksmall molecule
DB00418 SecobarbitalDrugbanksmall molecule
DB00420 PromazineDrugbanksmall molecule
DB00425 ZolpidemDrugbanksmall molecule
DB00428 StreptozocinDrugbanksmall molecule
DB00435 Nitric OxideDrugbanksmall molecule
DB00440 TrimethoprimDrugbanksmall molecule
DB00454 MeperidineDrugbanksmall molecule
DB00455 LoratadineDrugbanksmall molecule
DB00458 ImipramineDrugbanksmall molecule
DB00461 NabumetoneDrugbanksmall molecule
DB00467 EnoxacinDrugbanksmall molecule
DB00468 QuinineDrugbanksmall molecule
DB00472 FluoxetineDrugbanksmall molecule
DB00476 DuloxetineDrugbanksmall molecule
DB00477 ChlorpromazineDrugbanksmall molecule
DB00487 PefloxacinDrugbanksmall molecule
DB00499 FlutamideDrugbanksmall molecule
DB00501 CimetidineDrugbanksmall molecule
DB00502 HaloperidolDrugbanksmall molecule
DB00503 RitonavirDrugbanksmall molecule
DB00518 AlbendazoleDrugbanksmall molecule
DB00530 ErlotinibDrugbanksmall molecule
DB00532 MephenytoinDrugbanksmall molecule
DB00533 RofecoxibDrugbanksmall molecule
DB00537 CiprofloxacinDrugbanksmall molecule
DB00540 NortriptylineDrugbanksmall molecule
DB00544 FluorouracilDrugbanksmall molecule
DB00549 ZafirlukastDrugbanksmall molecule
DB00553 MethoxsalenSwissprotsmall molecule
DB00564 CarbamazepineDrugbanksmall molecule
DB00568 CinnarizineDrugbanksmall molecule
DB00571 PropranololDrugbanksmall molecule
DB00574 FenfluramineDrugbanksmall molecule
DB00575 ClonidineDrugbanksmall molecule
DB00586 DiclofenacDrugbanksmall molecule
DB00607 NafcillinDrugbanksmall molecule
DB00619 ImatinibDrugbanksmall molecule
DB00625 EfavirenzDrugbanksmall molecule
DB00629 GuanabenzDrugbanksmall molecule
DB00633 DexmedetomidineDrugbanksmall molecule
DB00655 EstroneDrugbanksmall molecule
DB00661 VerapamilDrugbanksmall molecule
DB00675 TamoxifenDrugbanksmall molecule
DB00682 WarfarinDrugbanksmall molecule
DB00685 TrovafloxacinDrugbanksmall molecule
DB00697 TizanidineDrugbanksmall molecule
DB00715 ParoxetineDrugbanksmall molecule
DB00717 NorethisteroneDrugbanksmall molecule
DB00730 ThiabendazoleDrugbanksmall molecule
DB00740 RiluzoleDrugbanksmall molecule
DB00744 ZileutonDrugbanksmall molecule
DB00745 ModafinilDrugbanksmall molecule
DB00752 TranylcypromineDrugbanksmall molecule
DB00758 ClopidogrelDrugbanksmall molecule
DB00763 MethimazoleDrugbanksmall molecule
DB00772 MalathionDrugbanksmall molecule
DB00773 EtoposideDrugbanksmall molecule
DB00779 Nalidixic acidSwissprotsmall molecule
DB00783 EstradiolDrugbanksmall molecule
DB00788 NaproxenDrugbanksmall molecule
DB00794 PrimidoneDrugbanksmall molecule
DB00806 PentoxifyllineDrugbanksmall molecule
DB00817 RosoxacinDrugbanksmall molecule
DB00818 PropofolDrugbanksmall molecule
DB00827 CinoxacinDrugbanksmall molecule
DB00831 TrifluoperazineDrugbanksmall molecule
DB00850 PerphenazineDrugbanksmall molecule
DB00851 DacarbazineDrugbanksmall molecule
DB00857 TerbinafineDrugbanksmall molecule
DB00863 RanitidineDrugbanksmall molecule
DB00898 EthanolDrugbanksmall molecule
DB00904 OndansetronDrugbanksmall molecule
DB00908 QuinidineDrugbanksmall molecule
DB00924 CyclobenzaprineDrugbanksmall molecule
DB00927 FamotidineDrugbanksmall molecule
DB00934 MaprotilineDrugbanksmall molecule
DB00951 IsoniazidDrugbanksmall molecule
DB00969 AlosetronDrugbanksmall molecule
DB00972 AzelastineDrugbanksmall molecule
DB00977 EthinylestradiolDrugbanksmall molecule
DB00978 LomefloxacinDrugbanksmall molecule
DB00980 RamelteonDrugbanksmall molecule
DB00993 AzathioprineDrugbanksmall molecule
DB00998 FrovatriptanDrugbanksmall molecule
DB01002 LevobupivacaineDrugbanksmall molecule
DB01012 CinacalcetDrugbanksmall molecule
DB01026 KetoconazoleDrugbanksmall molecule
DB01028 MethoxyfluraneDrugbanksmall molecule
DB01037 SelegilineDrugbanksmall molecule
DB01044 GatifloxacinDrugbanksmall molecule
DB01045 RifampicinDrugbanksmall molecule
DB01056 TocainideDrugbanksmall molecule
DB01058 PraziquantelSwissprotsmall molecule
DB01059 NorfloxacinDrugbanksmall molecule
DB01065 MelatoninDrugbanksmall molecule
DB01072 AtazanavirDrugbanksmall molecule
DB01079 TegaserodDrugbanksmall molecule
DB01087 PrimaquineDrugbanksmall molecule
DB01094 HesperetinDrugbanksmall molecule
DB01097 LeflunomideDrugbanksmall molecule
DB01100 PimozideDrugbanksmall molecule
DB01115 NifedipineDrugbanksmall molecule
DB01118 AmiodaroneDrugbanksmall molecule
DB01129 RabeprazoleDrugbanksmall molecule
DB01136 CarvedilolDrugbanksmall molecule
DB01137 LevofloxacinDrugbanksmall molecule
DB01142 DoxepinDrugbanksmall molecule
DB01151 DesipramineDrugbanksmall molecule
DB01155 GemifloxacinDrugbanksmall molecule
DB01165 OfloxacinDrugbanksmall molecule
DB01166 CilostazolDrugbanksmall molecule
DB01173 OrphenadrineDrugbanksmall molecule
DB01174 PhenobarbitalDrugbanksmall molecule
DB01182 PropafenoneDrugbanksmall molecule
DB01184 DomperidoneDrugbanksmall molecule
DB01191 DexfenfluramineDrugbanksmall molecule
DB01195 FlecainideDrugbanksmall molecule
DB01208 SparfloxacinDrugbanksmall molecule
DB01217 AnastrozoleDrugbanksmall molecule
DB01223 AminophyllineDrugbanksmall molecule
DB01233 MetoclopramideDrugbanksmall molecule
DB01241 GemfibrozilDrugbanksmall molecule
DB01242 ClomipramineDrugbanksmall molecule
DB01254 DasatinibDrugbanksmall molecule
DB01283 LumiracoxibDrugbanksmall molecule
DB01303 OxtriphyllineDrugbanksmall molecule
DB01306 Insulin aspartDrugbankbiotech
DB01307 Insulin detemirDrugbankbiotech
DB01309 Insulin glulisineDrugbankbiotech
DB01320 FosphenytoinDrugbanksmall molecule
DB01367 RasagilineDrugbanksmall molecule
DB01388 MibefradilDrugbanksmall molecule
DB01405 TemafloxacinDrugbanksmall molecule
DB01412 TheobromineDrugbanksmall molecule
DB01418 AcenocoumarolDrugbanksmall molecule
DB01424 AminophenazoneSwissprotsmall molecule
DB01435 AntipyrineDrugbanksmall molecule
DB01482 FenethyllineSwissprotsmall molecule
DB01558 BromazepamDrugbanksmall molecule
DB01601 LopinavirDrugbanksmall molecule
DB01609 DeferasiroxSwissprotsmall molecule
DB01623 ThiothixeneDrugbanksmall molecule
DB01628 EtoricoxibDrugbanksmall molecule
DB01645 GenisteinDrugbanksmall molecule
DB01667 8-azaguanineDrugbanksmall molecule
DB02134 XanthineDrugbanksmall molecule
DB02489 9-MethylguanineDrugbanksmall molecule
DB02709 ResveratrolDrugbanksmall molecule
DB03783 PhenacetinDrugbanksmall molecule
DB04076 HypoxanthineDrugbanksmall molecule
DB04356 9-DeazaguanineDrugbanksmall molecule
DB04574 Estrone sulfateDrugbanksmall molecule
DB04841 FlunarizineDrugbanksmall molecule
DB04871 LorcaserinDrugbanksmall molecule
DB04889 BicifadineDrugbanksmall molecule
DB04948 LofexidineDrugbanksmall molecule
DB04951 PirfenidoneSwissprotsmall molecule
DB05015 BelinostatDrugbanksmall molecule
DB05115 NN344Drugbanksmall molecule
DB05258 Interferon alfaDrugbankbiotech
DB05396 Albinterferon Alfa-2BSwissprotbiotech
DB05488 Technetium Tc-99m ciprofloxacinDrugbanksmall molecule
DB05676 ApremilastDrugbanksmall molecule
DB05708 GTS-21Drugbanksmall molecule
DB05812 AbirateroneDrugbanksmall molecule
DB05928 DovitinibDrugbanksmall molecule
DB05990 Obeticholic acidDrugbanksmall molecule
DB06077 LumateperoneDrugbanksmall molecule
DB06137 TirbanibulinDrugbanksmall molecule
DB06148 MianserinDrugbanksmall molecule
DB06160 GarenoxacinSwissprotsmall molecule
DB06210 EltrombopagDrugbanksmall molecule
DB06216 AsenapineDrugbanksmall molecule
DB06235 VadimezanSwissprotsmall molecule
DB06264 TolperisoneSwissprotsmall molecule
DB06290 SimeprevirDrugbanksmall molecule
DB06292 DapagliflozinDrugbanksmall molecule
DB06413 ArmodafinilDrugbanksmall molecule
DB06442 AvasimibeDrugbanksmall molecule
DB06448 LonafarnibDrugbanksmall molecule
DB06479 PropentofyllineDrugbanksmall molecule
DB06510 MuraglitazarDrugbanksmall molecule
DB06589 PazopanibDrugbanksmall molecule
DB06594 AgomelatineDrugbanksmall molecule
DB06595 MidostaurinDrugbanksmall molecule
DB06600 NemonoxacinSwissprotsmall molecule
DB06605 ApixabanDrugbanksmall molecule
DB06626 AxitinibDrugbanksmall molecule
DB06654 SafinamideDrugbanksmall molecule
DB06732 beta-NaphthoflavoneDrugbanksmall molecule
DB06769 BendamustineSwissprotsmall molecule
DB06770 Benzyl alcoholSwissprotsmall molecule
DB06771 BesifloxacinDrugbanksmall molecule
DB06774 CapsaicinDrugbanksmall molecule
DB06803 NiclosamideSwissprotsmall molecule
DB06820 SulconazoleSwissprotsmall molecule
DB07453 alpha-NaphthoflavoneDrugbanksmall molecule
DB08496 (R)-warfarinSwissprotsmall molecule
DB08867 UlipristalDrugbanksmall molecule
DB08880 TeriflunomideDrugbanksmall molecule
DB08881 VemurafenibDrugbanksmall molecule
DB08883 PerampanelDrugbanksmall molecule
DB08910 PomalidomideDrugbanksmall molecule
DB08972 FlumequineSwissprotsmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB09071 TasimelteonDrugbanksmall molecule
DB09078 LenvatinibDrugbanksmall molecule
DB09118 StiripentolDrugbanksmall molecule
DB09120 ZucapsaicinDrugbanksmall molecule
DB09122 Peginterferon beta-1aSwissprotbiotech
DB09167 DosulepinDrugbanksmall molecule
DB09185 ViloxazineDrugbanksmall molecule
DB09198 LobeglitazoneDrugbanksmall molecule
DB09225 ZotepineDrugbanksmall molecule
DB09241 Methylene blueDrugbanksmall molecule
DB09256 TegafurDrugbanksmall molecule
DB09273 DoxofyllineDrugbanksmall molecule
DB09288 PropacetamolDrugbanksmall molecule
DB09290 RamosetronDrugbanksmall molecule
DB09330 OsimertinibDrugbanksmall molecule
DB09456 Insulin beefSwissprotbiotech
DB09564 Insulin degludecDrugbankbiotech
DB09570 IxazomibSwissprotsmall molecule
DB11198 Peppermint oilSwissprotbiotech
DB11404 EnrofloxacinSwissprotsmall molecule
DB11443 OrbifloxacinSwissprotsmall molecule
DB11450 PimobendanSwissprotsmall molecule
DB11491 SarafloxacinSwissprotsmall molecule
DB11511 DifloxacinSwissprotsmall molecule
DB11567 Insulin peglisproSwissprotbiotech
DB11568 Insulin tregopilSwissprotbiotech
DB11642 PitolisantDrugbanksmall molecule
DB11672 CurcuminDrugbanksmall molecule
DB11689 SelumetinibDrugbanksmall molecule
DB11737 IcotinibDrugbanksmall molecule
DB11753 RifamycinDrugbanksmall molecule
DB11757 IstradefyllineDrugbanksmall molecule
DB11774 PazufloxacinSwissprotsmall molecule
DB11791 CapmatinibDrugbanksmall molecule
DB11837 OsilodrostatDrugbanksmall molecule
DB11892 PrulifloxacinSwissprotsmall molecule
DB11932 AbametapirSwissprotsmall molecule
DB11967 BinimetinibDrugbanksmall molecule
DB11994 DiacereinDrugbanksmall molecule
DB12001 AbemaciclibDrugbanksmall molecule
DB12026 VoxilaprevirDrugbanksmall molecule
DB12161 DeutetrabenazineDrugbanksmall molecule
DB12245 TriclabendazoleDrugbanksmall molecule
DB12332 RucaparibDrugbanksmall molecule
DB12406 LisofyllineSwissprotsmall molecule
DB12499 ClascoteroneDrugbanksmall molecule
DB12814 Cepeginterferon alfa-2BSwissprotbiotech
DB12945 DihydralazineSwissprotsmall molecule
DB13174 RheinDrugbanksmall molecule
DB13203 BamifyllineSwissprotsmall molecule
DB13261 SitafloxacinSwissprotsmall molecule
DB13449 ProxyphyllineSwissprotsmall molecule
DB13573 AcefyllineSwissprotsmall molecule
DB13592 EtamiphyllineSwissprotsmall molecule
DB13609 UmifenovirSwissprotsmall molecule
DB13627 Oxolinic acidSwissprotsmall molecule
DB13634 PentifyllineSwissprotsmall molecule
DB13772 RufloxacinSwissprotsmall molecule
DB13812 BufyllineSwissprotsmall molecule
DB13823 Pipemidic acidSwissprotsmall molecule
DB13874 EnasidenibDrugbanksmall molecule
DB13952 Estradiol acetateDrugbanksmall molecule
DB13953 Estradiol benzoateDrugbanksmall molecule
DB13954 Estradiol cypionateDrugbanksmall molecule
DB13955 Estradiol dienanthateDrugbanksmall molecule
DB13956 Estradiol valerateDrugbanksmall molecule
DB13975 Black cohoshSwissprotbiotech
DB14009 Medical CannabisDrugbankbiotech
DB14011 NabiximolsDrugbanksmall molecule
DB14018 BromotheophyllineSwissprotsmall molecule
DB14025 ClinafloxacinSwissprotsmall molecule
DB14029 FurafyllineSwissprotsmall molecule
DB14132 8-chlorotheophyllineDrugbanksmall molecule
DB14635 Curcumin sulfateDrugbanksmall molecule
DB14999 Human interferon betaDrugbankbiotech
DB15093 SomapacitanDrugbankbiotech
DB15119 Ropeginterferon alfa-2bSwissprotbiotech
DB15131 Interferon alfa-2cSwissprotbiotech
DB15444 ElexacaftorDrugbanksmall molecule
DB15822 PralsetinibDrugbanksmall molecule

Interactions

4 interactions