Entity Details

Primary name CSF1R_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07333
EntryNameCSF1R_HUMAN
FullNameMacrophage colony-stimulating factor 1 receptor
TaxID9606
Evidenceevidence at protein level
Length972
SequenceStatuscomplete
DateCreated1988-04-01
DateModified2021-06-02

Ontological Relatives

GenesCSF1R

GO terms

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GOName
GO:0001934 positive regulation of protein phosphorylation
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002931 response to ischemia
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005011 macrophage colony-stimulating factor receptor activity
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007411 axon guidance
GO:0008283 cell population proliferation
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0008360 regulation of cell shape
GO:0009986 cell surface
GO:0010759 positive regulation of macrophage chemotaxis
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0019903 protein phosphatase binding
GO:0019955 cytokine binding
GO:0021772 olfactory bulb development
GO:0021879 forebrain neuron differentiation
GO:0030097 hemopoiesis
GO:0030224 monocyte differentiation
GO:0030225 macrophage differentiation
GO:0030316 osteoclast differentiation
GO:0030335 positive regulation of cell migration
GO:0031529 ruffle organization
GO:0032722 positive regulation of chemokine production
GO:0033674 positive regulation of kinase activity
GO:0036006 cellular response to macrophage colony-stimulating factor stimulus
GO:0038145 macrophage colony-stimulating factor signaling pathway
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043235 receptor complex
GO:0044794 positive regulation by host of viral process
GO:0045087 innate immune response
GO:0045124 regulation of bone resorption
GO:0045217 cell-cell junction maintenance
GO:0046488 phosphatidylinositol metabolic process
GO:0046777 protein autophosphorylation
GO:0048015 phosphatidylinositol-mediated signaling
GO:0060260 regulation of transcription initiation from RNA polymerase II promoter
GO:0060603 mammary gland duct morphogenesis
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0061518 microglial cell proliferation
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071345 cellular response to cytokine stimulus
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0120041 positive regulation of macrophage proliferation
GO:1990682 CSF1-CSF1R complex
GO:2000147 positive regulation of cell motility
GO:2000249 regulation of actin cytoskeleton reorganization

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001824 Tyrosine-protein kinase, receptor class III, conserved siteSiteConserved site
IPR003598 Immunoglobulin subtype 2DomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013151 ImmunoglobulinDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR030658 Macrophage colony-stimulating factor 1 receptorFamilyFamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00619 ImatinibDrugbanksmall molecule
DB01268 SunitinibDrugbanksmall molecule
DB06080 ABT-869Drugbanksmall molecule
DB07167 5-CYANO-FURAN-2-CARBOXYLIC ACID [5-HYDROXYMETHYL-2-(4-METHYL-PIPERIDIN-1-YL)-PHENYL]-AMIDEDrugbanksmall molecule
DB07202 6-CHLORO-3-(3-METHYLISOXAZOL-5-YL)-4-PHENYLQUINOLIN-2(1H)-ONEDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB12147 ErdafitinibDrugbanksmall molecule
DB12978 PexidartinibDrugbanksmall molecule

Interactions

30 interactions

InteractorPartnerSourcesPublicationsLink
CSF1R_HUMANFYN_HUMANBioGRID, HPRD, MINT7681396 details
CSF1R_HUMANGRAP2_HUMANBioGRID, HPRD, IntAct25241761 9857184 details
CSF1R_HUMANCSF1R_HUMANBioGRID, DIP, HPRD10022833 11297560 1833648 22153499 9380408 details
CSF1R_HUMANCSF1_HUMANBioGRID, DIP, HPRD22153499 22483114 22902366 2408759 26235028 8355686 details
CSF1R_HUMANIL34_HUMANDIP22483114 23478061 details
CSF1R_HUMANCTDS2_HUMANBioGRID, MINT28065597 details
CSF1R_HUMANCTDS1_HUMANBioGRID, MINT28065597 details
CSF1R_HUMANGRB2_HUMANBioGRID, HPRD10025673 7597091 8262059 9178909 9380408 details
CSF1R_HUMANSOCS1_HUMANBioGRID, HPRD10022833 11297560 29991678 details
CSF1R_HUMANCBL_HUMANBioGRID, HPRD10025673 10648820 11847211 11850825 7782294 details
CSF1R_HUMANSTAP2_HUMANBioGRID17512498 details
CSF1R_HUMANP85B_HUMANBioGRID, HPRD1334406 details
CSF1R_HUMANKIT_HUMANBioGRID9949175 details
CSF1R_HUMANPK3CA_HUMANBioGRID9380408 details
CSF1R_HUMANLAMC2_HUMANBioGRID18593464 details
CSF1R_HUMANSHIP1_HUMANHPRD15735664 details
CSF1R_HUMANSHIP2_HUMANHPRD15735664 details
CSF1R_HUMANTHOC5_HUMANHPRD10597251 details
CSF1R_HUMANHS90B_HUMANIntAct22939624 details
CSF1R_HUMANP85A_HUMANBioGRID, HPRD, IntAct10025673 25241761 8947469 details
CSF1R_HUMANSRC_HUMANBioGRID7681396 details
CSF1R_HUMANYES_HUMANBioGRID, HPRD7681396 details
CSF1R_HUMANSOCS3_HUMANBioGRID, HPRD12133942 details
CSF1R_HUMANLYN_HUMANBioGRID, HPRD7636265 details
CSF1R_HUMANSOS1_HUMANBioGRID, HPRD10025673 7520523 details
CSF1R_HUMANSHC1_HUMANBioGRID, HPRD10025673 7520523 details
CSF1R_HUMANITAV_HUMANBioGRID16600665 details
CSF1R_HUMANHS90A_HUMANBioGRID22939624 details
CSF1R_HUMANPDCL3_HUMANBioGRID23792958 details
CSF1R_HUMANRASA1_HUMANHPRD2172781 details