Entity Details

Primary name HMGB1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP09429
EntryNameHMGB1_HUMAN
FullNameHigh mobility group protein B1
TaxID9606
Evidenceevidence at protein level
Length215
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesHMGB1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000400 four-way junction DNA binding
GO:0000405 bubble DNA binding
GO:0000793 condensed chromosome
GO:0000976 transcription cis-regulatory region binding
GO:0001530 lipopolysaccharide binding
GO:0001654 eye development
GO:0001773 myeloid dendritic cell activation
GO:0001786 phosphatidylserine binding
GO:0001935 endothelial cell proliferation
GO:0002218 activation of innate immune response
GO:0002224 toll-like receptor signaling pathway
GO:0002270 plasmacytoid dendritic cell activation
GO:0002281 macrophage activation involved in immune response
GO:0002407 dendritic cell chemotaxis
GO:0002437 inflammatory response to antigenic stimulus
GO:0002643 regulation of tolerance induction
GO:0002840 regulation of T cell mediated immune response to tumor cell
GO:0003684 damaged DNA binding
GO:0003690 double-stranded DNA binding
GO:0003697 single-stranded DNA binding
GO:0003713 transcription coactivator activity
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0003727 single-stranded RNA binding
GO:0005125 cytokine activity
GO:0005178 integrin binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005769 early endosome
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0006265 DNA topological change
GO:0006284 base-excision repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006309 apoptotic DNA fragmentation
GO:0006310 DNA recombination
GO:0006342 chromatin silencing
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006914 autophagy
GO:0006954 inflammatory response
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008134 transcription factor binding
GO:0008301 DNA binding, bending
GO:0009986 cell surface
GO:0010508 positive regulation of autophagy
GO:0010858 calcium-dependent protein kinase regulator activity
GO:0016032 viral process
GO:0016829 lyase activity
GO:0017053 transcription repressor complex
GO:0017055 negative regulation of RNA polymerase II transcription preinitiation complex assembly
GO:0019958 C-X-C chemokine binding
GO:0030295 protein kinase activator activity
GO:0030324 lung development
GO:0031175 neuron projection development
GO:0031497 chromatin assembly
GO:0032072 regulation of restriction endodeoxyribonuclease activity
GO:0032392 DNA geometric change
GO:0032425 positive regulation of mismatch repair
GO:0032689 negative regulation of interferon-gamma production
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032732 positive regulation of interleukin-1 production
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033151 V(D)J recombination
GO:0034137 positive regulation of toll-like receptor 2 signaling pathway
GO:0034145 positive regulation of toll-like receptor 4 signaling pathway
GO:0034165 positive regulation of toll-like receptor 9 signaling pathway
GO:0034774 secretory granule lumen
GO:0035711 T-helper 1 cell activation
GO:0035767 endothelial cell chemotaxis
GO:0035868 alphav-beta3 integrin-HMGB1 complex
GO:0042056 chemoattractant activity
GO:0042104 positive regulation of activated T cell proliferation
GO:0043005 neuron projection
GO:0043065 positive regulation of apoptotic process
GO:0043277 apoptotic cell clearance
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043312 neutrophil degranulation
GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation
GO:0043388 positive regulation of DNA binding
GO:0043410 positive regulation of MAPK cascade
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0045063 T-helper 1 cell differentiation
GO:0045087 innate immune response
GO:0045639 positive regulation of myeloid cell differentiation
GO:0045819 positive regulation of glycogen catabolic process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046330 positive regulation of JNK cascade
GO:0050786 RAGE receptor binding
GO:0051106 positive regulation of DNA ligation
GO:0051384 response to glucocorticoid
GO:0070182 DNA polymerase binding
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071222 cellular response to lipopolysaccharide
GO:0071639 positive regulation of monocyte chemotactic protein-1 production
GO:0090026 positive regulation of monocyte chemotaxis
GO:0090303 positive regulation of wound healing
GO:0097100 supercoiled DNA binding
GO:0097350 neutrophil clearance
GO:0098761 cellular response to interleukin-7
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1903672 positive regulation of sprouting angiogenesis
GO:1904813 ficolin-1-rich granule lumen
GO:1905564 positive regulation of vascular endothelial cell proliferation
GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production
GO:2000426 negative regulation of apoptotic cell clearance
GO:2000819 regulation of nucleotide-excision repair
GO:2001200 positive regulation of dendritic cell differentiation

Subcellular Location

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Subcellular Location
Cell membrane
Chromosome
Cytoplasm
Endoplasmic reticulum-Golgi intermediate compartment
Endosome
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR009071 High mobility group box domainDomainDomain
IPR017967 HMG box A DNA-binding domain, conserved siteSiteConserved site
IPR031076 High mobility group protein HMGB1FamilyFamily
IPR036910 High mobility group box domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00608 ChloroquineDrugbanksmall molecule
DB05869 Ethyl pyruvateDrugbanksmall molecule

Interactions

149 interactions

InteractorPartnerSourcesPublicationsLink
HMGB1_HUMANP53_HUMANBioGRID, DIP, HPRD, IntAct11106654 11748221 23063560 9472015 details
HMGB1_HUMANTBP_HUMANBioGRID, HPRD, IntAct8006019 9880542 details
HMGB1_HUMANP73_HUMANBioGRID, HPRD, IntAct11748232 details
HMGB1_HUMANU119A_HUMANBioGRID, HPRD, IntAct16169070 details
HMGB1_HUMANERG28_HUMANBioGRID, HPRD, IntAct16169070 details
HMGB1_HUMANDPYL1_HUMANBioGRID, HPRD, IntAct16169070 details
HMGB1_HUMANTHIO_HUMANMINT18996119 details
HMGB1_HUMANHMGA1_HUMANBioGRID, IntAct18850631 details
HMGB1_HUMANZNF24_HUMANBioGRID, IntAct20195357 details
HMGB1_HUMANDYN2_HUMANBioGRID, MINT21900206 details
HMGB1_HUMANATRAP_HUMANBioGRID, IntAct25416956 details
HMGB1_HUMANRAGE_HUMANBioGRID, HPRD, UniProt24474694 25495026 9812979 details
HMGB1_HUMANTERF2_HUMANbhf-ucl, BioGRID21044950 details
HMGB1_HUMANTE2IP_HUMANbhf-ucl, BioGRID21044950 details
HMGB1_HUMANDUX4_HUMANBioGRID, IntAct26816005 details
HMGB1_HUMANCCDB1_HUMANBioGRID, IntAct32296183 details
HMGB1_HUMANPCNA_HUMANUniProt26030842 details
HMGB1_HUMANRSF1_HUMANBioGRID, UniProt29721183 31694235 32867128 details
HMGB1_HUMANHNRPU_HUMANBioGRID, UniProt29721183 31694235 details
HMGB1_HUMANSRSF3_HUMANBioGRID, UniProt29721183 31694235 details
HMGB1_HUMANHNRPK_HUMANBioGRID, HPRD, UniProt11748221 29721183 details
HMGB1_HUMANRS20_HUMANBioGRID, UniProt29721183 details
HMGB1_HUMANRS12_HUMANBioGRID, UniProt29721183 details
HMGB1_HUMANPARP1_HUMANBioGRID, UniProt28190768 29721183 34079125 details
HMGB1_HUMANENAH_HUMANBioGRID, UniProt29721183 details
HMGB1_HUMANFIP1_HUMANBioGRID, UniProt29721183 details
HMGB1_HUMANK2C7_HUMANBioGRID, UniProt29721183 31694235 32867128 details
HMGB1_HUMANSPIT1_HUMANBioGRID, UniProt29721183 details
HMGB1_HUMANUBC9_HUMANBioGRID, UniProt29721183 details
HMGB1_HUMANEIF1_HUMANBioGRID, UniProt29721183 details
HMGB1_HUMANGCP60_HUMANBioGRID, UniProt29721183 details
HMGB1_HUMANC1QBP_HUMANBioGRID, UniProt29721183 details
HMGB1_HUMANCCAR1_HUMANBioGRID, UniProt29721183 details
HMGB1_HUMANCTBL1_HUMANBioGRID, UniProt29721183 details
HMGB1_HUMANBIP_HUMANBioGRID, UniProt29721183 details
HMGB1_HUMANNEXN_HUMANBioGRID, UniProt29721183 details
HMGB1_HUMANPCOC1_HUMANBioGRID, UniProt29721183 details
HMGB1_HUMANRL29_HUMANBioGRID, UniProt29721183 32867128 details
HMGB1_HUMANZN428_HUMANBioGRID, UniProt29721183 31694235 details
HMGB1_HUMANCO3_HUMANBioGRID, UniProt29721183 details
HMGB1_HUMANMT2_HUMANBioGRID, UniProt29721183 31694235 details
HMGB1_HUMANA4_HUMANIntAct32814053 details
HMGB1_HUMANODP2_HUMANUniProt31694235 details
HMGB1_HUMANKTU_HUMANUniProt31694235 details
HMGB1_HUMANVIGLN_HUMANUniProt31694235 details
HMGB1_HUMANSPIN1_HUMANUniProt31694235 details
HMGB1_HUMANUB2E3_HUMANUniProt31694235 details
HMGB1_HUMANUBXN1_HUMANUniProt31694235 details
HMGB1_HUMANUHRF2_HUMANUniProt31694235 32867128 details
HMGB1_HUMANFOS_HUMANUniProt31694235 details
HMGB1_HUMANGOLM1_HUMANUniProt31694235 details
HMGB1_HUMANMAP1B_HUMANUniProt31694235 details
HMGB1_HUMANMAPK5_HUMANUniProt31694235 details
HMGB1_HUMANMIEN1_HUMANUniProt31694235 details
HMGB1_HUMANPSA7_HUMANUniProt31694235 details
HMGB1_HUMANPTN2_HUMANUniProt31694235 details
HMGB1_HUMANNGAP_HUMANUniProt31694235 details
HMGB1_HUMANTAF3_HUMANUniProt31694235 details
HMGB1_HUMANTGM3_HUMANUniProt31694235 details
HMGB1_HUMANUBC_HUMANUniProt31694235 details
HMGB1_HUMANWNK4_HUMANUniProt31694235 details
HMGB1_HUMANTYY1_HUMANUniProt31694235 details
HMGB1_HUMANAKIP1_HUMANUniProt32867128 details
HMGB1_HUMANMCAF1_HUMANUniProt32867128 details
HMGB1_HUMANDC2I1_HUMANUniProt32867128 details
HMGB1_HUMANC1QA_HUMANUniProt32867128 details
HMGB1_HUMANDAG1_HUMANUniProt32867128 details
HMGB1_HUMANTGM2_HUMANUniProt32867128 details
HMGB1_HUMANNFKB1_HUMANBioGRID, HPRD12604365 details
HMGB1_HUMANLRIF1_HUMANBioGRID, HPRD16169070 details
HMGB1_HUMANHXB1_HUMANBioGRID8890171 details
HMGB1_HUMANHXB3_HUMANBioGRID8890171 details
HMGB1_HUMANHXC6_HUMANBioGRID8890171 details
HMGB1_HUMANHXD3_HUMANBioGRID8890171 details
HMGB1_HUMANHXD8_HUMANBioGRID8890171 details
HMGB1_HUMANHXD9_HUMANBioGRID, HPRD8890171 details
HMGB1_HUMANHXD10_HUMANBioGRID8890171 details
HMGB1_HUMANHXD11_HUMANBioGRID8890171 details
HMGB1_HUMANPLMN_HUMANBioGRID, HPRD1909331 details
HMGB1_HUMANNCAN_HUMANBioGRID, HPRD9507007 details
HMGB1_HUMANPTPRZ_HUMANBioGRID9507007 details
HMGB1_HUMANRB_HUMANBioGRID, HPRD11748221 details
HMGB1_HUMANMECP2_HUMANBioGRID, HPRD11748221 details
HMGB1_HUMANTLE1_HUMANBioGRID, HPRD11748221 details
HMGB1_HUMANTLE5_HUMANBioGRID, HPRD11748221 details
HMGB1_HUMANTF2AA_HUMANBioGRID9880542 details
HMGB1_HUMANRAG1_HUMANBioGRID, HPRD10490593 details
HMGB1_HUMANPRGR_HUMANBioGRID9671457 details
HMGB1_HUMANGCR_HUMANBioGRID9671457 details
HMGB1_HUMANANDR_HUMANBioGRID, HPRD11748221 9671457 details
HMGB1_HUMANCDK1_HUMANBioGRID2013279 details
HMGB1_HUMANCBP_HUMANBioGRID15005629 details
HMGB1_HUMANXPC_HUMANBioGRID19446504 details
HMGB1_HUMANRD23B_HUMANBioGRID19446504 details
HMGB1_HUMANPSN1_HUMANBioGRID21163940 details
HMGB1_HUMANHPF1_HUMANBioGRID28190768 details
HMGB1_HUMANEP300_HUMANBioGRID27585400 details
HMGB1_HUMANKC1A_HUMANBioGRID, HPRD, MINT12062430 details
HMGB1_HUMANRIF1_HUMANIntAct16169070 details
HMGB1_HUMANETS1_HUMANIntAct20195357 details
HMGB1_HUMANBECN1_HUMANBioGRID, UniProt20819940 29361549 details
HMGB1_HUMANTLR4_HUMANHPRD, MINT, UniProt16267105 20067962 20547845 details
HMGB1_HUMANHD_HUMANUniProt23303669 details
HMGB1_HUMANMLP3B_HUMANUniProt23303669 details
HMGB1_HUMANMSH2_HUMANUniProt15014079 details
HMGB1_HUMANUBE2N_HUMANBioGRID, IntAct27173435 unassigned1312 details
HMGB1_HUMANGFAP_HUMANBioGRID, IntAct28514442 29382328 details
HMGB1_HUMANH33_HUMANBioGRID, UniProt17403666 29721183 details
HMGB1_HUMANHSP7C_HUMANBioGRID, UniProt12517784 29721183 details
HMGB1_HUMANTLR2_HUMANHPRD, MINT16267105 20067962 details
HMGB1_HUMANTF65_HUMANBioGRID, HPRD12665595 details
HMGB1_HUMANPO5F1_HUMANBioGRID, HPRD11099378 21151833 details
HMGB1_HUMANTPA_HUMANBioGRID, HPRD1909331 8366113 details
HMGB1_HUMANHMGB2_HUMANBioGRID12517784 24981860 26344197 details
HMGB1_HUMANPDIA3_HUMANBioGRID12517784 24981860 details
HMGB1_HUMANXPA_HUMANBioGRID19446504 details
HMGB1_HUMANHNF1A_HUMANBioGRID18160415 details
HMGB1_HUMANCTDP1_HUMANBioGRID12591939 details
HMGB1_HUMANU2AF2_HUMANBioGRID26641092 details
HMGB1_HUMANSDF1_HUMANBioGRID25495026 details
HMGB1_HUMANCXCR4_HUMANBioGRID25495026 details
HMGB1_HUMANRFOX3_HUMANBioGRID29382328 details
HMGB1_HUMANKPCA_HUMANHPRD10617144 details
HMGB1_HUMANCUX1_HUMANHPRD11748221 details
HMGB1_HUMANDNMT1_HUMANHPRD11748221 details
HMGB1_HUMANHES1_HUMANHPRD11748221 details
HMGB1_HUMANSUH_HUMANHPRD11748221 details
HMGB1_HUMANIRF2_HUMANHPRD11748221 details
HMGB1_HUMANCEBPB_HUMANHPRD11748221 details
HMGB1_HUMANTTP_HUMANHPRD11748221 details
HMGB1_HUMANTAF1_HUMANHPRD11748221 9880542 details
HMGB1_HUMANTFE3_HUMANHPRD11748221 details
HMGB1_HUMANRFX1_HUMANHPRD11748221 details
HMGB1_HUMANCASP3_HUMANHPRD11748221 details
HMGB1_HUMANPRKDC_HUMANHPRD9722660 details
HMGB1_HUMANTLE2_HUMANHPRD11748221 details
HMGB1_HUMANFOXC1_HUMANHPRD11748221 details
HMGB1_HUMANATOH1_HUMANHPRD11748221 details
HMGB1_HUMANFOXA3_HUMANHPRD11748221 details
HMGB1_HUMANHAIR_HUMANHPRD11748221 details
HMGB1_HUMANTGIF1_HUMANHPRD11748221 details
HMGB1_HUMANMNT_HUMANHPRD11748221 details
HMGB1_HUMANCTCF_HUMANHPRD11748221 details
HMGB1_HUMANSOX18_HUMANHPRD11748221 details
HMGB1_HUMANSIX5_HUMANHPRD11748221 details
HMGB1_HUMANP2R3A_HUMANHPRD11748221 details
HMGB1_HUMANERF_HUMANHPRD11748221 details
HMGB1_HUMANNDF6_HUMANHPRD11748221 details
HMGB1_HUMANRASF4_HUMANHPRD11748221 details