Entity Details

Primary name IAPP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10997
EntryNameIAPP_HUMAN
FullNameIslet amyloid polypeptide
TaxID9606
Evidenceevidence at protein level
Length89
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesIAPP

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0005102 signaling receptor binding
GO:0005179 hormone activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007267 cell-cell signaling
GO:0008285 negative regulation of cell population proliferation
GO:0010628 positive regulation of gene expression
GO:0010739 positive regulation of protein kinase A signaling
GO:0010823 negative regulation of mitochondrion organization
GO:0010942 positive regulation of cell death
GO:0016234 inclusion body
GO:0019233 sensory perception of pain
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031648 protein destabilization
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0042755 eating behavior
GO:0042802 identical protein binding
GO:0043025 neuronal cell body
GO:0043065 positive regulation of apoptotic process
GO:0043410 positive regulation of MAPK cascade
GO:0045596 negative regulation of cell differentiation
GO:0045779 negative regulation of bone resorption
GO:0051260 protein homooligomerization
GO:0051897 positive regulation of protein kinase B signaling
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0097647 amylin receptor signaling pathway
GO:1905665 positive regulation of calcium ion import across plasma membrane
GO:1905907 negative regulation of amyloid fibril formation
GO:1990000 amyloid fibril formation

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000443 Islet amyloid polypeptideFamilyFamily
IPR001693 Calcitonin peptide-likeDomainDomain
IPR018360 Calcitonin, conserved siteSiteConserved site
IPR021116 Calcitonin/adrenomedullinFamilyFamily
IPR021117 Calcitonin-likeFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB09130 CopperDrugbanksmall molecule