Entity Details

Primary name PUR6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP22234
EntryNamePUR6_HUMAN
FullNameMultifunctional protein ADE2
TaxID9606
Evidenceevidence at protein level
Length425
SequenceStatuscomplete
DateCreated1991-08-01
DateModified2021-06-02

Ontological Relatives

GenesPAICS

GO terms

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GOName
GO:0004638 phosphoribosylaminoimidazole carboxylase activity
GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006189 'de novo' IMP biosynthetic process
GO:0009113 purine nucleobase biosynthetic process
GO:0009168 purine ribonucleoside monophosphate biosynthetic process
GO:0016020 membrane
GO:0042802 identical protein binding
GO:0043727 5-amino-4-imidazole carboxylate lyase activity
GO:0045296 cadherin binding
GO:0070062 extracellular exosome

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000031 PurE domainDomainDomain
IPR018236 SAICAR synthetase, conserved siteSiteConserved site
IPR028923 SAICAR synthetase/ADE2, N-terminalDomainDomain
IPR033626 Class II PurEDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00128 Aspartic acidDrugbanksmall molecule

Interactions

27 interactions

InteractorPartnerSourcesPublicationsLink
PUR6_HUMANPUR6_HUMANBioGRID, HPRD, IntAct16169070 16189514 16501559 21988832 25416956 32296183 details
PUR6_HUMANCHD3_HUMANBioGRID, HPRD, IntAct16169070 details
PUR6_HUMANPHOCN_HUMANBioGRID, HPRD, IntAct16169070 details
PUR6_HUMANCEP76_HUMANBioGRID, HPRD, IntAct16189514 details
PUR6_HUMANFXR2_HUMANBioGRID, HPRD, IntAct, MINT16189514 19060904 21653829 details
PUR6_HUMANNUD18_HUMANBioGRID, HPRD, IntAct16189514 19060904 details
PUR6_HUMANLNX1_HUMANBioGRID, HPRD, IntAct16189514 32296183 details
PUR6_HUMANNIF3L_HUMANBioGRID, IntAct19060904 details
PUR6_HUMANAAKG1_HUMANBioGRID, IntAct21988832 details
PUR6_HUMANSMRD1_HUMANBioGRID, IntAct21988832 details
PUR6_HUMANLMBL2_HUMANBioGRID, IntAct25416956 26871637 details
PUR6_HUMANTERF1_HUMANbhf-ucl, BioGRID21044950 details
PUR6_HUMANPIAS2_HUMANBioGRID, IntAct32296183 details
PUR6_HUMANRNF4_HUMANBioGRID, IntAct32296183 details
PUR6_HUMANZMYM2_HUMANBioGRID, IntAct32296183 details
PUR6_HUMANCDC37_HUMANBioGRID, IntAct32296183 details
PUR6_HUMANARIP4_HUMANBioGRID, IntAct32296183 details
PUR6_HUMANPILRA_HUMANBioGRID32296183 details
PUR6_HUMANUBC9_HUMANBioGRID32296183 details
PUR6_HUMANUBE3A_HUMANBioGRID31329371 details
PUR6_HUMANCCNA1_HUMANIntAct17353931 details
PUR6_HUMANEIF1B_HUMANIntAct17353931 details
PUR6_HUMANTRM7_HUMANIntAct17353931 details
PUR6_HUMANSGK1_HUMANIntAct17353931 details
PUR6_HUMANTIMP2_HUMANIntAct17353931 details
PUR6_HUMANFXR1_HUMANMINT21653829 details
PUR6_HUMANU2AF2_HUMANBioGRID26641092 details