Entity Details

Primary name GLRA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP23415
EntryNameGLRA1_HUMAN
FullNameGlycine receptor subunit alpha-1
TaxID9606
Evidenceevidence at protein level
Length457
SequenceStatuscomplete
DateCreated1991-11-01
DateModified2021-06-02

Ontological Relatives

GenesGLRA1

GO terms

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GOName
GO:0001508 action potential
GO:0001964 startle response
GO:0002087 regulation of respiratory gaseous exchange by nervous system process
GO:0004888 transmembrane signaling receptor activity
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006811 ion transport
GO:0006821 chloride transport
GO:0006936 muscle contraction
GO:0007165 signal transduction
GO:0007218 neuropeptide signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007340 acrosome reaction
GO:0007601 visual perception
GO:0007628 adult walking behavior
GO:0008270 zinc ion binding
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
GO:0016594 glycine binding
GO:0016934 extracellularly glycine-gated chloride channel activity
GO:0030425 dendrite
GO:0030594 neurotransmitter receptor activity
GO:0030977 taurine binding
GO:0034220 ion transmembrane transport
GO:0034707 chloride channel complex
GO:0042391 regulation of membrane potential
GO:0042802 identical protein binding
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043200 response to amino acid
GO:0043204 perikaryon
GO:0043231 intracellular membrane-bounded organelle
GO:0044305 calyx of Held
GO:0044877 protein-containing complex binding
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0050877 nervous system process
GO:0050884 neuromuscular process controlling posture
GO:0051970 negative regulation of transmission of nerve impulse
GO:0060012 synaptic transmission, glycinergic
GO:0060013 righting reflex
GO:0060077 inhibitory synapse
GO:0060080 inhibitory postsynaptic potential
GO:0071230 cellular response to amino acid stimulus
GO:0071294 cellular response to zinc ion
GO:0071361 cellular response to ethanol
GO:0097305 response to alcohol
GO:0098690 glycinergic synapse
GO:0099056 integral component of presynaptic membrane
GO:0099060 integral component of postsynaptic specialization membrane
GO:1902476 chloride transmembrane transport
GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
GO:2000344 positive regulation of acrosome reaction

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Perikaryon

Domains

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DomainNameCategoryType
IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alphaFamilyFamily
IPR006029 Neurotransmitter-gated ion-channel transmembrane domainDomainDomain
IPR006201 Neurotransmitter-gated ion-channelFamilyFamily
IPR006202 Neurotransmitter-gated ion-channel ligand-binding domainDomainDomain
IPR008127 Glycine receptor alphaFamilyFamily
IPR008128 Glycine receptor alpha1FamilyFamily
IPR018000 Neurotransmitter-gated ion-channel, conserved siteSiteConserved site
IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamilyFamilyHomologous superfamily
IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00145 GlycineDrugbanksmall molecule
DB00228 EnfluraneDrugbanksmall molecule
DB00431 LindaneDrugbanksmall molecule
DB00466 PicrotoxinDrugbanksmall molecule
DB00572 AtropineDrugbanksmall molecule
DB00753 IsofluraneDrugbanksmall molecule
DB00898 EthanolDrugbanksmall molecule
DB01028 MethoxyfluraneDrugbanksmall molecule
DB01043 MemantineDrugbanksmall molecule
DB01159 HalothaneDrugbanksmall molecule
DB01189 DesfluraneDrugbanksmall molecule
DB01236 SevofluraneDrugbanksmall molecule
DB01381 Ginkgo bilobaDrugbankbiotech
DB01593 ZincDrugbanksmall molecule
DB01956 TaurineDrugbanksmall molecule
DB03929 D-SerineDrugbanksmall molecule
DB05417 GW 468816Drugbanksmall molecule
DB05885 SeletracetamDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB11582 ThiocolchicosideDrugbanksmall molecule
DB14009 Medical CannabisDrugbankbiotech
DB14011 NabiximolsDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
GLRA1_HUMANVINEX_HUMANBioGRID, IntAct32296183 details
GLRA1_HUMANMAGD1_HUMANBioGRID, IntAct32296183 details
GLRA1_HUMANGLRA1_HUMANDIP20023641 23994010 details