Entity Details

Primary name GUC2C_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP25092
EntryNameGUC2C_HUMAN
FullNameHeat-stable enterotoxin receptor
TaxID9606
Evidenceevidence at protein level
Length1073
SequenceStatuscomplete
DateCreated1992-05-01
DateModified2021-06-02

Ontological Relatives

GenesGUCY2C

GO terms

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GOName
GO:0001653 peptide receptor activity
GO:0004383 guanylate cyclase activity
GO:0004672 protein kinase activity
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0006182 cGMP biosynthetic process
GO:0007165 signal transduction
GO:0007168 receptor guanylyl cyclase signaling pathway
GO:0007586 digestion
GO:0009636 response to toxic substance
GO:0015643 toxic substance binding
GO:0016021 integral component of membrane
GO:0016941 natriuretic peptide receptor activity
GO:0017046 peptide hormone binding
GO:0035556 intracellular signal transduction
GO:0042127 regulation of cell population proliferation

Subcellular Location

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Subcellular Location
Cell membrane
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclaseDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR018297 Adenylyl cyclase class-4/guanylyl cyclase, conserved siteSiteConserved site
IPR028082 Periplasmic binding protein-like IFamilyHomologous superfamily
IPR029787 Nucleotide cyclaseFamilyHomologous superfamily
IPR042822 Membrane Guanylate Cyclase receptor GC-C, pseudokinase domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB08890 LinaclotideDrugbanksmall molecule

Interactions

4 interactions