Entity Details

Primary name MT3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP25713
EntryNameMT3_HUMAN
FullNameMetallothionein-3
TaxID9606
Evidenceevidence at protein level
Length68
SequenceStatuscomplete
DateCreated1992-05-01
DateModified2021-06-02

Ontological Relatives

GenesMT3

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0001934 positive regulation of protein phosphorylation
GO:0005507 copper ion binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006112 energy reserve metabolic process
GO:0006707 cholesterol catabolic process
GO:0006829 zinc ion transport
GO:0006875 cellular metal ion homeostasis
GO:0006882 cellular zinc ion homeostasis
GO:0008021 synaptic vesicle
GO:0008270 zinc ion binding
GO:0010038 response to metal ion
GO:0010273 detoxification of copper ion
GO:0010507 negative regulation of autophagy
GO:0010628 positive regulation of gene expression
GO:0010940 positive regulation of necrotic cell death
GO:0010942 positive regulation of cell death
GO:0010977 negative regulation of neuron projection development
GO:0014002 astrocyte development
GO:0016209 antioxidant activity
GO:0016234 inclusion body
GO:0016570 histone modification
GO:0019430 removal of superoxide radicals
GO:0030295 protein kinase activator activity
GO:0030308 negative regulation of cell growth
GO:0030517 negative regulation of axon extension
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032095 regulation of response to food
GO:0032148 activation of protein kinase B activity
GO:0033210 leptin-mediated signaling pathway
GO:0034599 cellular response to oxidative stress
GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043085 positive regulation of catalytic activity
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043491 protein kinase B signaling
GO:0043524 negative regulation of neuron apoptotic process
GO:0044242 cellular lipid catabolic process
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046870 cadmium ion binding
GO:0046872 metal ion binding
GO:0048471 perinuclear region of cytoplasm
GO:0050821 protein stabilization
GO:0051354 negative regulation of oxidoreductase activity
GO:0055069 zinc ion homeostasis
GO:0055073 cadmium ion homeostasis
GO:0060049 regulation of protein glycosylation
GO:0060547 negative regulation of necrotic cell death
GO:0070371 ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071276 cellular response to cadmium ion
GO:0071280 cellular response to copper ion
GO:0071294 cellular response to zinc ion
GO:0071456 cellular response to hypoxia
GO:0071732 cellular response to nitric oxide
GO:0097214 positive regulation of lysosomal membrane permeability
GO:2000117 negative regulation of cysteine-type endopeptidase activity
GO:2000376 positive regulation of oxygen metabolic process
GO:2000378 negative regulation of reactive oxygen species metabolic process

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000006 Metallothionein, vertebrateFamilyFamily
IPR003019 MetallothioneinFamilyFamily
IPR017854 Metallothionein domain superfamilyFamilyHomologous superfamily
IPR018064 Metallothionein, vertebrate, metal binding siteSiteBinding site
IPR023587 Metallothionein domain superfamily, vertebrateFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01593 ZincDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB12965 SilverDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
MT3_HUMANTTHY_HUMANBioGRID, MINT20646067 details
MT3_HUMANTE2IP_HUMANbhf-ucl, BioGRID21044950 details