Entity Details

Primary name TNR5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP25942
EntryNameTNR5_HUMAN
FullNameTumor necrosis factor receptor superfamily member 5
TaxID9606
Evidenceevidence at protein level
Length277
SequenceStatuscomplete
DateCreated1992-05-01
DateModified2021-06-02

Ontological Relatives

GenesCD40

GO terms

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GOName
GO:0001934 positive regulation of protein phosphorylation
GO:0002768 immune response-regulating cell surface receptor signaling pathway
GO:0003823 antigen binding
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006874 cellular calcium ion homeostasis
GO:0006954 inflammatory response
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0019724 B cell mediated immunity
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0023035 CD40 signaling pathway
GO:0030168 platelet activation
GO:0030890 positive regulation of B cell proliferation
GO:0031625 ubiquitin protein ligase binding
GO:0032735 positive regulation of interleukin-12 production
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0033590 response to cobalamin
GO:0034341 response to interferon-gamma
GO:0035631 CD40 receptor complex
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0036018 cellular response to erythropoietin
GO:0038023 signaling receptor activity
GO:0042100 B cell proliferation
GO:0042113 B cell activation
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042832 defense response to protozoan
GO:0043025 neuronal cell body
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043196 varicosity
GO:0043231 intracellular membrane-bounded organelle
GO:0043406 positive regulation of MAP kinase activity
GO:0043491 protein kinase B signaling
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043547 positive regulation of GTPase activity
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0050776 regulation of immune response
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051607 defense response to virus
GO:0065003 protein-containing complex assembly
GO:0070062 extracellular exosome
GO:0071222 cellular response to lipopolysaccharide
GO:0071260 cellular response to mechanical stimulus
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0090037 positive regulation of protein kinase C signaling
GO:1901652 response to peptide
GO:2000353 positive regulation of endothelial cell apoptotic process

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR001368 TNFR/NGFR cysteine-rich regionDomainDomain
IPR020435 Tumour necrosis factor receptor 5FamilyFamily
IPR034021 Tumour necrosis factor receptor 5, N-terminalDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB06360 LucatumumabDrugbankbiotech
DB12589 DacetuzumabDrugbankbiotech

Interactions

60 interactions

InteractorPartnerSourcesPublicationsLink
TNR5_HUMANTRAF3_HUMANBioGRID, HPRD, IntAct10352240 10984535 11562359 12220533 12637493 14517219 16260598 17878343 19667091 20614026 21041727 24260396 24810049 26779844 27716849 32041822 7527023 7530216 7533327 7859281 9168896 9384571 9718306 9990007 details
TNR5_HUMANTRAF6_HUMANBioGRID, HPRD, InnateDB, IntAct10075662 10411888 12140561 12220533 12637493 16260598 20449947 20614026 20676093 21041727 24812060 9384571 9718306 9990007 details
TNR5_HUMANTRAF2_HUMANBioGRID, HPRD, InnateDB, IntAct10352240 10411888 11562359 12220533 12637493 16260598 17353931 19667091 20449947 20614026 20676093 21041727 21071692 21282461 25416956 25502805 25910212 27716849 31515488 32041822 32296183 9020361 9168896 9718306 9990007 details
TNR5_HUMANTRAF5_HUMANBioGRID, HPRD, InnateDB11562359 12220533 20614026 20676093 21041727 26779844 8790348 9511754 9990007 details
TNR5_HUMANMIP_HUMANBioGRID, IntAct32296183 details
TNR5_HUMANMFSD5_HUMANBioGRID, IntAct32296183 details
TNR5_HUMANTM147_HUMANBioGRID, IntAct32296183 details
TNR5_HUMANS39AD_HUMANBioGRID, IntAct32296183 details
TNR5_HUMANTLCD1_HUMANBioGRID, IntAct32296183 details
TNR5_HUMANCYAC3_HUMANBioGRID, IntAct32296183 details
TNR5_HUMANCKLF6_HUMANBioGRID, IntAct32296183 details
TNR5_HUMANINSI2_HUMANBioGRID, IntAct32296183 details
TNR5_HUMANTM128_HUMANBioGRID, IntAct32296183 details
TNR5_HUMANSL7A1_HUMANBioGRID, IntAct32296183 details
TNR5_HUMANMYPR_HUMANBioGRID, IntAct32296183 details
TNR5_HUMANTM107_HUMANBioGRID, IntAct32296183 details
TNR5_HUMANEBP_HUMANBioGRID, IntAct32296183 details
TNR5_HUMANMAL_HUMANBioGRID, IntAct32296183 details
TNR5_HUMANCKLF5_HUMANBioGRID, IntAct32296183 details
TNR5_HUMANDB121_HUMANBioGRID, IntAct32296183 details
TNR5_HUMANZNT3_HUMANBioGRID, IntAct32296183 details
TNR5_HUMANZNT2_HUMANBioGRID, IntAct32296183 details
TNR5_HUMANNCOA6_HUMANBioGRID10847592 details
TNR5_HUMANTYDP2_HUMANBioGRID, HPRD10764746 details
TNR5_HUMANXRCC6_HUMANBioGRID, HPRD10514012 details
TNR5_HUMANXRCC5_HUMANBioGRID, HPRD10514012 details
TNR5_HUMANHSP74_HUMANBioGRID, HPRD12356871 details
TNR5_HUMANTANK_HUMANBioGRID17878343 26779844 details
TNR5_HUMANFAF1_HUMANBioGRID24810049 details
TNR5_HUMANPSMD1_HUMANIntAct17353931 details
TNR5_HUMANPIMT_HUMANIntAct17353931 details
TNR5_HUMANMYCBP_HUMANIntAct17353931 details
TNR5_HUMANKTNA1_HUMANIntAct17353931 details
TNR5_HUMANOGT1_HUMANIntAct17353931 details
TNR5_HUMANRIPK2_HUMANBioGRID, HPRD9642260 details
TNR5_HUMANCD20_HUMANBioGRID, HPRD9933087 details
TNR5_HUMANCIKS_HUMANBioGRID, HPRD12089335 15485634 24120361 details
TNR5_HUMANTRAF1_HUMANBioGRID, HPRD10411888 20614026 7527023 9718306 details
TNR5_HUMANBIRC2_HUMANBioGRID, HPRD11562359 20614026 21041727 details
TNR5_HUMANTRAF4_HUMANBioGRID11562359 details
TNR5_HUMANPK3CA_HUMANBioGRID12637493 details
TNR5_HUMANCBL_HUMANBioGRID, HPRD12637493 details
TNR5_HUMANM3K8_HUMANBioGRID, HPRD15670770 details
TNR5_HUMANIL4RA_HUMANBioGRID, HPRD12207328 details
TNR5_HUMANCD40L_HUMANBioGRID, HPRD10647992 23918987 7516405 7543281 details
TNR5_HUMANP85A_HUMANBioGRID, HPRD12637493 21200133 details
TNR5_HUMANIKKA_HUMANBioGRID20614026 details
TNR5_HUMANDBLOH_HUMANBioGRID20614026 details
TNR5_HUMANTNR5_HUMANBioGRID20614026 details
TNR5_HUMANIKKB_HUMANBioGRID20614026 details
TNR5_HUMANRNF31_HUMANBioGRID20614026 details
TNR5_HUMANHTRA2_HUMANBioGRID20614026 details
TNR5_HUMANSTING_HUMANBioGRID27716849 details
TNR5_HUMANM3K1_HUMANBioGRID32041822 details
TNR5_HUMANNEMO_HUMANBioGRID32041822 details
TNR5_HUMANFAN_HUMANHPRD10601289 details
TNR5_HUMANCAV1_HUMANHPRD14665433 details
TNR5_HUMANBIRC3_HUMANHPRD11562359 details
TNR5_HUMANHSP7C_HUMANHPRD12356871 details
TNR5_HUMANJAK3_HUMANHPRD10395671 9133417 details