Entity Details

Primary name 2AAA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP30153
EntryName2AAA_HUMAN
FullNameSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
TaxID9606
Evidenceevidence at protein level
Length589
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesPPP2R1A

GO terms

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GOName
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000159 protein phosphatase type 2A complex
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000188 obsolete inactivation of MAPK activity
GO:0000775 chromosome, centromeric region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006275 regulation of DNA replication
GO:0006355 regulation of transcription, DNA-templated
GO:0006470 protein dephosphorylation
GO:0006672 ceramide metabolic process
GO:0006915 apoptotic process
GO:0007059 chromosome segregation
GO:0007084 mitotic nuclear membrane reassembly
GO:0008287 protein serine/threonine phosphatase complex
GO:0008380 RNA splicing
GO:0010033 response to organic substance
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0016328 lateral plasma membrane
GO:0019888 protein phosphatase regulator activity
GO:0019932 second-messenger-mediated signaling
GO:0030111 regulation of Wnt signaling pathway
GO:0030155 regulation of cell adhesion
GO:0030308 negative regulation of cell growth
GO:0030425 dendrite
GO:0040008 regulation of growth
GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein
GO:0045595 regulation of cell differentiation
GO:0046982 protein heterodimerization activity
GO:0065003 protein-containing complex assembly
GO:0070062 extracellular exosome
GO:0097711 ciliary basal body-plasma membrane docking
GO:1990405 protein antigen binding

Subcellular Location

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Subcellular Location
Cell projection
Chromosome
Cytoplasm
Lateral cell membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000357 HEAT repeatRepeatRepeat
IPR011989 Armadillo-like helicalFamilyHomologous superfamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR021133 HEAT, type 2RepeatRepeat
IPR031090 Serine/threonine-protein phosphatase 2A subunit A, metazoaFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB02506 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic AcidDrugbanksmall molecule
DB06905 (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acidDrugbanksmall molecule

Interactions

127 interactions

InteractorPartnerSourcesPublicationsLink
2AAA_HUMANSMAD2_HUMANBioGRID, HPRD, MINT15231748 details
2AAA_HUMANSMAD3_HUMANBioGRID, HPRD, MINT15231748 details
2AAA_HUMANZFYV9_HUMANBioGRID, HPRD, MINT15231748 details
2AAA_HUMANCFTR_HUMANBioGRID, IntAct, MINT15936019 17110338 26618866 29924966 details
2AAA_HUMANPP2AB_HUMANBioGRID, IntAct, MINT12370081 15936019 18782753 19156129 23443559 24981860 26186194 26344197 26496610 27173435 27880917 28330616 28514442 unassigned1312 details
2AAA_HUMANARI2_HUMANBioGRID, HPRD, IntAct16169070 details
2AAA_HUMANAKT1_HUMANBioGRID, MINT16044149 22569334 details
2AAA_HUMANPP2AA_HUMANBioGRID, DIP, HPRD, IntAct10191253 12370081 15761952 17055435 17274953 17374643 17529992 17540176 17632056 18394995 18715871 18782753 19156129 19293187 19818709 19915589 21159657 21460856 22167190 22379092 22863883 22939629 23443559 24841198 25438055 26344197 26496610 27880917 28330616 8617797 details
2AAA_HUMAN2A5G_HUMANBioGRID, DIP, I2D, IntAct, MINT15380617 17245430 17529992 18782753 19156129 19915589 21460856 23443559 26344197 26496610 27173435 28330616 8617797 unassigned1312 details
2AAA_HUMAN2ABA_HUMANBioGRID, DIP, HPRD, IntAct, MINT12370081 15761952 17245430 17529992 17540176 17632056 18782753 19156129 19293187 19915589 20711181 22939629 23443559 26344197 26496610 27173435 28330616 32950569 unassigned1312 details
2AAA_HUMAN2A5A_HUMANBioGRID, HPRD, IntAct, MINT11856313 12370081 17245430 18782753 20220139 26344197 26496610 28330616 7592815 details
2AAA_HUMANPLAT3_HUMANBioGRID, HPRD, IntAct17374643 details
2AAA_HUMANSTRN3_HUMANBioGRID, HPRD, IntAct17540176 18782753 19156129 22939629 23443559 26496610 28330616 32296183 details
2AAA_HUMANSTRN_HUMANBioGRID, HPRD, IntAct17540176 18782753 19156129 23443559 24255178 26496610 28330616 32296183 details
2AAA_HUMAN2A5D_HUMANBioGRID, IntAct18782753 19156129 19293187 22939629 23443559 23555304 26344197 26496610 27173435 28330616 32296183 unassigned1312 details
2AAA_HUMAN2A5E_HUMANBioGRID, IntAct18782753 19156129 23443559 23555304 26344197 26496610 27173435 28330616 unassigned1312 details
2AAA_HUMAN2A5B_HUMANBioGRID, IntAct18782753 32296183 details
2AAA_HUMANP2R3B_HUMANBioGRID, HPRD, IntAct10629059 12370081 18782753 26496610 28330616 details
2AAA_HUMANTAB1_HUMANBioGRID, IntAct21988832 details
2AAA_HUMANAIMP2_HUMANBioGRID, MINT21900206 details
2AAA_HUMANMK06_HUMANBioGRID, MINT21900206 details
2AAA_HUMANGNA12_HUMANHPRD, MINT15525651 details
2AAA_HUMANPPP5_HUMANHPRD, MINT11504734 details
2AAA_HUMANCSK2B_HUMANBioGRID, IntAct23555304 details
2AAA_HUMANBHE40_HUMANIntAct23555304 details
2AAA_HUMANRORG_HUMANBioGRID, IntAct23555304 details
2AAA_HUMANDUX4_HUMANBioGRID, IntAct26816005 details
2AAA_HUMANGOG6A_HUMANBioGRID, IntAct32296183 details
2AAA_HUMANPTPA_HUMANBioGRID, IntAct19818709 32296183 details
2AAA_HUMANCSDC2_HUMANBioGRID, IntAct25416956 31515488 32296183 details
2AAA_HUMANFBX43_HUMANBioGRID, IntAct32296183 details
2AAA_HUMANCHSP1_HUMANBioGRID, IntAct32296183 details
2AAA_HUMANGOG8F_HUMANIntAct32296183 details
2AAA_HUMANNUP62_HUMANDIP25435324 details
2AAA_HUMANM3K7_HUMANBioGRID17079228 details
2AAA_HUMANDAPK1_HUMANBioGRID20220139 details
2AAA_HUMANESR1_HUMANBioGRID20348541 26389696 details
2AAA_HUMANDCAF1_HUMANBioGRID25720411 26281983 details
2AAA_HUMANNOSIP_HUMANBioGRID25546391 details
2AAA_HUMANCAR11_HUMANBioGRID21157432 details
2AAA_HUMANCDC42_HUMANBioGRID31478661 details
2AAA_HUMANSUMO2_HUMANBioGRID32786267 details
2AAA_HUMANAMOL2_HUMANBioGRID32950569 details
2AAA_HUMANOGT1_HUMANBioGRID32994395 details
2AAA_HUMANIPO9_HUMANHPRD12670497 details
2AAA_HUMANHSF2_HUMANHPRD10224043 details
2AAA_HUMANM3K3_HUMANIntAct14743216 details
2AAA_HUMANTRM7_HUMANIntAct17353931 details
2AAA_HUMANIF6_HUMANIntAct17353931 details
2AAA_HUMANTNIK_HUMANIntAct17353931 details
2AAA_HUMANPP4C_HUMANBioGRID, HPRD, IntAct17353931 18715871 19156129 27880917 28330616 details
2AAA_HUMANEIF1B_HUMANIntAct17353931 details
2AAA_HUMANBCAR3_HUMANIntAct17353931 details
2AAA_HUMANNDKB_HUMANIntAct17353931 details
2AAA_HUMANTRAF6_HUMANIntAct17353931 details
2AAA_HUMANPHB2_HUMANIntAct17353931 details
2AAA_HUMANP53_HUMANBioGRID, IntAct, MINT12665691 17245430 25241761 details
2AAA_HUMANCCNG1_HUMANBioGRID, IntAct, MINT17245430 28330616 details
2AAA_HUMANPPME1_HUMANBioGRID, IntAct15761952 17274953 18394995 18782753 19156129 19293187 26496610 26499835 28330616 details
2AAA_HUMANSGO1_HUMANBioGRID, HPRD, IntAct16541024 16541025 19156129 28330616 details
2AAA_HUMAN2ABD_HUMANBioGRID, IntAct18782753 19156129 20220139 26344197 26496610 27173435 28330616 28514442 unassigned1312 details
2AAA_HUMANANKL2_HUMANBioGRID, IntAct19156129 23443559 26496610 27173435 28330616 unassigned1312 details
2AAA_HUMAN2ABB_HUMANBioGRID, IntAct17274953 19156129 21075311 23135275 26344197 26496610 28330616 details
2AAA_HUMAN2ABG_HUMANBioGRID, IntAct18782753 19156129 24841198 26186194 28330616 28514442 details
2AAA_HUMANCIP2A_HUMANBioGRID, IntAct17632056 19293187 details
2AAA_HUMANSTRN4_HUMANBioGRID, IntAct18782753 19156129 23443559 26496610 28330616 details
2AAA_HUMAN2AAB_HUMANBioGRID, IntAct17540176 18782753 23443559 26344197 26496610 details
2AAA_HUMANSIKE1_HUMANBioGRID, IntAct18782753 19156129 23443559 26496610 28330616 details
2AAA_HUMANHS90A_HUMANBioGRID, IntAct18172692 19875381 details
2AAA_HUMANTF65_HUMANMINT11591705 details
2AAA_HUMANFOXO3_HUMANBioGRID, MINT20110348 26280018 details
2AAA_HUMANCEP43_HUMANBioGRID, IntAct19156129 26496610 28330616 details
2AAA_HUMANSGO2_HUMANBioGRID, HPRD, IntAct16541025 26496610 details
2AAA_HUMANINT3_HUMANBioGRID, IntAct20133760 26496610 28330616 details
2AAA_HUMANC1QBP_HUMANBioGRID, IntAct18172692 26496610 details
2AAA_HUMANPRR14_HUMANBioGRID, IntAct19156129 26496610 28330616 28514442 details
2AAA_HUMANFGOP2_HUMANBioGRID, IntAct19156129 26496610 28330616 details
2AAA_HUMANINT1_HUMANBioGRID, IntAct20133760 26496610 28330616 details
2AAA_HUMANLPP_HUMANBioGRID, IntAct19156129 26496610 28330616 details
2AAA_HUMANINT6_HUMANBioGRID, IntAct20133760 26496610 28330616 details
2AAA_HUMANCHK2_HUMANBioGRID, IntAct15380617 23178491 details
2AAA_HUMANCF410_HUMANBioGRID, IntAct27173435 unassigned1312 details
2AAA_HUMANPRAF3_HUMANBioGRID, IntAct27173435 unassigned1312 details
2AAA_HUMANVAMP7_HUMANBioGRID, IntAct27173435 unassigned1312 details
2AAA_HUMANBBS12_HUMANBioGRID, IntAct27173435 unassigned1312 details
2AAA_HUMANINT5_HUMANBioGRID, IntAct20133760 28330616 details
2AAA_HUMANCE350_HUMANBioGRID, IntAct19156129 28330616 details
2AAA_HUMANHUNK_HUMANDIP20133759 details
2AAA_HUMANARHG7_HUMANDIP25150978 details
2AAA_HUMANAMRA1_HUMANBioGRID, DIP25438055 details
2AAA_HUMANAURKB_HUMANDIP26829474 details
2AAA_HUMANMLH1_HUMANBioGRID17148452 details
2AAA_HUMANPMS1_HUMANBioGRID17148452 details
2AAA_HUMANHDAC1_HUMANBioGRID17540176 details
2AAA_HUMANMARH1_HUMANBioGRID17540176 details
2AAA_HUMANHDAC5_HUMANBioGRID21081666 details
2AAA_HUMANCHIP_HUMANBioGRID19818709 details
2AAA_HUMANTRI18_HUMANBioGRID19818709 29062069 details
2AAA_HUMANHDAC4_HUMANBioGRID22466704 27684187 31040226 details
2AAA_HUMANSPY2_HUMANBioGRID17255109 details
2AAA_HUMANHSP7C_HUMANBioGRID18172692 details
2AAA_HUMANEF1A1_HUMANBioGRID18172692 details
2AAA_HUMANRSSA_HUMANBioGRID18172692 details
2AAA_HUMANANXA2_HUMANBioGRID18172692 details
2AAA_HUMANRS3_HUMANBioGRID18172692 23443559 details
2AAA_HUMANRACK1_HUMANBioGRID18172692 details
2AAA_HUMANNPM_HUMANBioGRID18172692 details
2AAA_HUMANRS8_HUMANBioGRID18172692 details
2AAA_HUMANPTN14_HUMANBioGRID22948661 details
2AAA_HUMANTERA_HUMANBioGRID20100830 23108140 31536960 details
2AAA_HUMANCAV1_HUMANBioGRID14645548 details
2AAA_HUMANKLH15_HUMANBioGRID23135275 details
2AAA_HUMANRAF1_HUMANBioGRID16041367 details
2AAA_HUMANAICDA_HUMANBioGRID23277564 details
2AAA_HUMANEGFR_HUMANBioGRID23956138 details
2AAA_HUMANESPL1_HUMANBioGRID24781523 details
2AAA_HUMANSIK2_HUMANBioGRID24841198 details
2AAA_HUMANMACD1_HUMANBioGRID25735744 details
2AAA_HUMANCDC20_HUMANBioGRID26811472 details
2AAA_HUMANBCL10_HUMANBioGRID21157432 details
2AAA_HUMANPECA1_HUMANBioGRID12775720 details
2AAA_HUMANCA131_HUMANBioGRID26472760 details
2AAA_HUMANDERL1_HUMANBioGRID28137758 details
2AAA_HUMANSYNEM_HUMANBioGRID22337773 details
2AAA_HUMANNMDE4_HUMANHPRD10862698 details
2AAA_HUMANNMDZ1_HUMANHPRD10862698 details
2AAA_HUMANSC6A2_HUMANHPRD15963952 details