Entity Details

Primary name FMO3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP31513
EntryNameFMO3_HUMAN
FullNameDimethylaniline monooxygenase [N-oxide-forming] 3
TaxID9606
Evidenceevidence at protein level
Length532
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesFMO3

GO terms

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GOName
GO:0004497 monooxygenase activity
GO:0004499 N,N-dimethylaniline monooxygenase activity
GO:0005789 endoplasmic reticulum membrane
GO:0006805 xenobiotic metabolic process
GO:0016021 integral component of membrane
GO:0034899 trimethylamine monooxygenase activity
GO:0043231 intracellular membrane-bounded organelle
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Microsome membrane

Domains

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DomainNameCategoryType
IPR000960 Flavin monooxygenase FMOFamilyFamily
IPR002255 Flavin monooxygenase (FMO) 3FamilyFamily
IPR020946 Flavin monooxygenase-likeFamilyFamily
IPR036188 FAD/NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00250 DapsoneDrugbanksmall molecule
DB00334 OlanzapineDrugbanksmall molecule
DB00363 ClozapineDrugbanksmall molecule
DB00501 CimetidineDrugbanksmall molecule
DB00582 VoriconazoleDrugbanksmall molecule
DB00675 TamoxifenDrugbanksmall molecule
DB00763 MethimazoleDrugbanksmall molecule
DB00768 OlopatadineDrugbanksmall molecule
DB00918 AlmotriptanDrugbanksmall molecule
DB01254 DasatinibDrugbanksmall molecule
DB05294 VandetanibDrugbanksmall molecule
DB11828 NeratinibDrugbanksmall molecule
DB12278 PropiverineDrugbanksmall molecule
DB12500 FedratinibDrugbanksmall molecule
DB13609 UmifenovirSwissprotsmall molecule
DB15305 RisdiplamSwissprotsmall molecule

Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
FMO3_HUMANSAC1_HUMANBioGRID, IntAct32296183 details
FMO3_HUMANSGSM3_HUMANBioGRID, IntAct32296183 details
FMO3_HUMANCLC10_HUMANBioGRID, IntAct32296183 details
FMO3_HUMANCREB3_HUMANBioGRID, IntAct25910212 31515488 details