Entity Details

Primary name DDIT3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35638
EntryNameDDIT3_HUMAN
FullNameDNA damage-inducible transcript 3 protein
TaxID9606
Evidenceevidence at protein level
Length169
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesDDIT3

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001955 blood vessel maturation
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0005770 late endosome
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006974 cellular response to DNA damage stimulus
GO:0006983 ER overload response
GO:0006986 response to unfolded protein
GO:0007605 sensory perception of sound
GO:0008134 transcription factor binding
GO:0008140 cAMP response element binding protein binding
GO:0009948 anterior/posterior axis specification
GO:0010506 regulation of autophagy
GO:0016055 Wnt signaling pathway
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032689 negative regulation of interferon-gamma production
GO:0032700 negative regulation of interleukin-17 production
GO:0032713 negative regulation of interleukin-4 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032792 negative regulation of CREB transcription factor activity
GO:0032993 protein-DNA complex
GO:0034976 response to endoplasmic reticulum stress
GO:0036488 CHOP-C/EBP complex
GO:0036499 PERK-mediated unfolded protein response
GO:0036500 ATF6-mediated unfolded protein response
GO:0042594 response to starvation
GO:0042803 protein homodimerization activity
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0043522 leucine zipper domain binding
GO:0043525 positive regulation of neuron apoptotic process
GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress
GO:0045454 cell redox homeostasis
GO:0045599 negative regulation of fat cell differentiation
GO:0045662 negative regulation of myoblast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046982 protein heterodimerization activity
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051898 negative regulation of protein kinase B signaling
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0072655 establishment of protein localization to mitochondrion
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0120163 negative regulation of cold-induced thermogenesis
GO:0140416 transcription regulator inhibitor activity
GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:1990442 intrinsic apoptotic signaling pathway in response to nitrosative stress
GO:1990617 CHOP-ATF4 complex
GO:1990622 CHOP-ATF3 complex
GO:2000016 negative regulation of determination of dorsal identity
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR004827 Basic-leucine zipper domainDomainDomain
IPR016670 DNA damage-inducible transcript 3FamilyFamily

Diseases

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Interactions

92 interactions

InteractorPartnerSourcesPublicationsLink
DDIT3_HUMANDHB14_HUMANBioGRID, HPRD, IntAct16189514 25416956 27107012 32296183 details
DDIT3_HUMANMCMBP_HUMANBioGRID, HPRD, IntAct16189514 32296183 details
DDIT3_HUMANSPOP_HUMANBioGRID, HPRD, IntAct16189514 24990631 details
DDIT3_HUMANBATF_HUMANBioGRID, DIP, HPIDb, HPRD, IntAct, UniProt16189514 18330356 20102225 23661758 27107012 details
DDIT3_HUMANCEBPG_HUMANBioGRID, HPIDb, HPRD, IntAct, UniProt12618752 16189514 20102225 20211142 23661758 25416956 details
DDIT3_HUMANDDIT3_HUMANBioGRID, IntAct, UniProt20562859 23661758 details
DDIT3_HUMANTEDC1_HUMANBioGRID, DIP, IntAct18330356 20562859 details
DDIT3_HUMANDBP_HUMANBioGRID, IntAct, UniProt21988832 23661758 details
DDIT3_HUMANTHRB_HUMANBioGRID, IntAct21988832 details
DDIT3_HUMANEP300_HUMANBioGRID, IntAct17872950 21988832 24270407 details
DDIT3_HUMANNEMO_HUMANBioGRID, IntAct21988832 details
DDIT3_HUMANIDD_HUMANBioGRID, IntAct21988832 details
DDIT3_HUMANRPAC2_HUMANBioGRID, IntAct21988832 details
DDIT3_HUMANIMA1_HUMANBioGRID, IntAct21988832 details
DDIT3_HUMANCDK6_HUMANBioGRID, IntAct22094256 details
DDIT3_HUMANVP37C_HUMANBioGRID, IntAct25416956 32296183 details
DDIT3_HUMANSNPC5_HUMANBioGRID, IntAct25416956 details
DDIT3_HUMANFOSL2_HUMANBioGRID, HPIDb, IntAct20102225 25416956 27107012 32296183 details
DDIT3_HUMANZBT25_HUMANBioGRID, IntAct25416956 details
DDIT3_HUMANRBTN2_HUMANBioGRID, IntAct25416956 details
DDIT3_HUMANCC153_HUMANBioGRID, IntAct25416956 details
DDIT3_HUMANZC3HE_HUMANBioGRID, IntAct25416956 details
DDIT3_HUMANEMSY_HUMANBioGRID, IntAct25416956 32296183 details
DDIT3_HUMANATPF2_HUMANBioGRID, IntAct25416956 details
DDIT3_HUMANBATF3_HUMANBioGRID, HPIDb, IntAct, UniProt20102225 20211142 23661758 25416956 32296183 details
DDIT3_HUMANAMOL2_HUMANBioGRID, IntAct25416956 details
DDIT3_HUMANFOS_HUMANBioGRID, HPIDb, HPRD, IntAct, UniProt10523647 20102225 23661758 26264872 29997244 31467278 32814053 details
DDIT3_HUMANATF3_HUMANBioGRID, HPIDb, HPRD, IntAct, UniProt20102225 20211142 23661758 26264872 27107012 29997244 31467278 32814053 8622660 details
DDIT3_HUMANBACH1_HUMANBioGRID, HPIDb, UniProt20102225 23661758 details
DDIT3_HUMANNFIL3_HUMANBioGRID, HPIDb, UniProt20102225 23661758 details
DDIT3_HUMANCEBPA_HUMANBioGRID, HPIDb, UniProt20102225 23661758 27555288 details
DDIT3_HUMANCEBPB_HUMANBioGRID, HPIDb, HPRD12706815 1547942 20102225 20562859 8662954 details
DDIT3_HUMANCEBPD_HUMANHPIDb20102225 details
DDIT3_HUMANATF4_HUMANBioGRID, DIP, HPIDb, HPRD, UniProt12805554 18330356 20102225 23661758 details
DDIT3_HUMANCREB3_HUMANBioGRID, HPIDb, UniProt20102225 23661758 details
DDIT3_HUMANHLF_HUMANHPIDb, UniProt20102225 23661758 details
DDIT3_HUMANATF2_HUMANBioGRID, HPIDb, UniProt20102225 23661758 details
DDIT3_HUMANATF7_HUMANHPIDb20102225 details
DDIT3_HUMANJUNB_HUMANBioGRID, HPIDb, UniProt20102225 23661758 details
DDIT3_HUMANPCM1_HUMANBioGRID, IntAct27107012 details
DDIT3_HUMANEFC4B_HUMANBioGRID, IntAct32296183 details
DDIT3_HUMANTHIOM_HUMANBioGRID, IntAct32296183 details
DDIT3_HUMANJDP2_HUMANBioGRID, IntAct32296183 details
DDIT3_HUMANCRBL2_HUMANBioGRID, IntAct32296183 details
DDIT3_HUMANTNF12_HUMANBioGRID, IntAct25416956 32296183 details
DDIT3_HUMANTXND2_HUMANBioGRID, IntAct32296183 details
DDIT3_HUMANLNX1_HUMANBioGRID, IntAct32296183 details
DDIT3_HUMANGIPC1_HUMANBioGRID, DIP18330356 details
DDIT3_HUMANNF2L2_HUMANIntAct32911434 details
DDIT3_HUMANGFAP_HUMANIntAct32814053 details
DDIT3_HUMANJPH3_HUMANIntAct32814053 details
DDIT3_HUMANCEBPE_HUMANBioGRID, HPRD, IntAct, UniProt15588942 20211142 23661758 details
DDIT3_HUMANBATF2_HUMANBioGRID, UniProt23661758 details
DDIT3_HUMANCR3L1_HUMANBioGRID, UniProt23661758 details
DDIT3_HUMANJUN_HUMANBioGRID, HPRD, UniProt10523647 23661758 details
DDIT3_HUMANFOSL1_HUMANBioGRID, UniProt23661758 details
DDIT3_HUMANMAFG_HUMANBioGRID, UniProt23661758 details
DDIT3_HUMANMAFF_HUMANBioGRID, UniProt23661758 details
DDIT3_HUMANBACH2_HUMANBioGRID, UniProt23661758 details
DDIT3_HUMANSSX3_HUMANBioGRID, IntAct20211142 details
DDIT3_HUMANRAI1_HUMANBioGRID, IntAct20211142 details
DDIT3_HUMANHXA5_HUMANBioGRID, IntAct20211142 details
DDIT3_HUMANZSC31_HUMANBioGRID, IntAct20211142 details
DDIT3_HUMANCSK21_HUMANBioGRID, HPRD12876286 details
DDIT3_HUMANJUND_HUMANBioGRID, HPRD10523647 details
DDIT3_HUMANRS3A_HUMANBioGRID, HPRD10713066 details
DDIT3_HUMANMK14_HUMANBioGRID, HPRD8650547 details
DDIT3_HUMANSRA1_HUMANBioGRID20398657 details
DDIT3_HUMANEPAS1_HUMANBioGRID23661758 details
DDIT3_HUMANGP1BA_HUMANBioGRID21988832 details
DDIT3_HUMANRPC22_HUMANBioGRID21988832 details
DDIT3_HUMANTRIB3_HUMANBioGRID, HPRD15775988 17872950 details
DDIT3_HUMANDNM3L_HUMANBioGRID24952347 details
DDIT3_HUMANGABR2_HUMANBioGRID16081421 details
DDIT3_HUMANRS3_HUMANBioGRID29371697 details
DDIT3_HUMANGIMA6_HUMANBioGRID32296183 details
DDIT3_HUMANHDAC1_HUMANBioGRID17872950 22242125 details
DDIT3_HUMANCSN7A_HUMANBioGRID23213463 details
DDIT3_HUMANCSN8_HUMANBioGRID23213463 details
DDIT3_HUMANCUL3_HUMANBioGRID23213463 details
DDIT3_HUMANCUL1_HUMANBioGRID23213463 details
DDIT3_HUMANCSN3_HUMANBioGRID23213463 details
DDIT3_HUMANKEAP1_HUMANBioGRID23213463 details
DDIT3_HUMANPPIB_HUMANBioGRID24270407 details
DDIT3_HUMANHDAC5_HUMANBioGRID17872950 details
DDIT3_HUMANHDAC6_HUMANBioGRID17872950 details
DDIT3_HUMANCBP_HUMANBioGRID20829347 details
DDIT3_HUMANGABR1_HUMANBioGRID16081421 details
DDIT3_HUMANBIP_HUMANBioGRID28947141 details
DDIT3_HUMANFUS_HUMANBioGRID30962207 details
DDIT3_HUMANSMCA4_HUMANBioGRID30962207 details
DDIT3_HUMANPICAL_HUMANHPRD1547942 details