Entity Details

Primary name KPCI_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP41743
EntryNameKPCI_HUMAN
FullNameProtein kinase C iota type
TaxID9606
Evidenceevidence at protein level
Length596
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesPRKCI

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004697 protein kinase C activity
GO:0004698 calcium-dependent protein kinase C activity
GO:0005524 ATP binding
GO:0005543 phospholipid binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005768 endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005923 bicellular tight junction
GO:0006468 protein phosphorylation
GO:0006612 protein targeting to membrane
GO:0007010 cytoskeleton organization
GO:0007015 actin filament organization
GO:0010976 positive regulation of neuron projection development
GO:0015630 microtubule cytoskeleton
GO:0016192 vesicle-mediated transport
GO:0016324 apical plasma membrane
GO:0016477 cell migration
GO:0018105 peptidyl-serine phosphorylation
GO:0031252 cell leading edge
GO:0032869 cellular response to insulin stimulus
GO:0034351 negative regulation of glial cell apoptotic process
GO:0035089 establishment of apical/basal cell polarity
GO:0035556 intracellular signal transduction
GO:0042462 eye photoreceptor cell development
GO:0043066 negative regulation of apoptotic process
GO:0043220 Schmidt-Lanterman incisure
GO:0043524 negative regulation of neuron apoptotic process
GO:0045171 intercellular bridge
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
GO:0045216 cell-cell junction organization
GO:0045747 positive regulation of Notch signaling pathway
GO:0046326 positive regulation of glucose import
GO:0046872 metal ion binding
GO:0046903 secretion
GO:0048194 Golgi vesicle budding
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0060252 positive regulation of glial cell proliferation
GO:0061024 membrane organization
GO:0070062 extracellular exosome
GO:0070555 response to interleukin-1
GO:0070830 bicellular tight junction assembly
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098978 glutamatergic synapse
GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1903078 positive regulation of protein localization to plasma membrane
GO:2000353 positive regulation of endothelial cell apoptotic process

Subcellular Location

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Subcellular Location
Cytoplasm
Endosome
Membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000270 PB1 domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR012233 Protein kinase CFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR017892 Protein kinase, C-terminalDomainDomain
IPR020454 Diacylglycerol/phorbol-ester bindingDomainDomain
IPR034661 Atypical protein kinase C iota type, catalytic domainDomainDomain
IPR034877 Protein kinase C, PB1 domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00675 TamoxifenDrugbanksmall molecule
DB03777 Bisindolylmaleimide IDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

68 interactions

InteractorPartnerSourcesPublicationsLink
KPCI_HUMANPAR6A_HUMANBioGRID, HPRD, IntAct, MINT11257119 11260256 12813044 14676191 15590654 16189514 16861740 17057644 21516116 25416956 26496610 32296183 details
KPCI_HUMANPAR6B_HUMANBioGRID, HPRD, IntAct11260256 14676191 23439680 23718855 25416956 26186194 26496610 28514442 31980649 32296183 details
KPCI_HUMANPAR6G_HUMANBioGRID, HPRD, IntAct11260256 14676191 30217970 31980649 details
KPCI_HUMANRAC1_HUMANHPRD, IntAct11260256 details
KPCI_HUMANCDC42_HUMANHPRD, IntAct10934474 11260256 14676191 details
KPCI_HUMANPARD3_HUMANBioGRID, HPRD, IntAct12459187 14676191 22883624 31980649 34079125 details
KPCI_HUMANMARK4_HUMANBioGRID, HPRD, IntAct14676191 26346160 details
KPCI_HUMANSQSTM_HUMANBioGRID, HPRD, IntAct, MINT12813044 14676191 16861740 20562859 20808283 26043024 26187466 29551772 30581152 31980649 32296183 34079125 9566925 details
KPCI_HUMAN1433Z_HUMANBioGRID, HPRD, IntAct12893243 14676191 details
KPCI_HUMANCASP8_HUMANBioGRID, IntAct21988832 details
KPCI_HUMANIL1AP_HUMANBioGRID, IntAct21988832 details
KPCI_HUMANNEMO_HUMANBioGRID, IntAct21988832 details
KPCI_HUMANFABP4_HUMANBioGRID, MINT21900206 details
KPCI_HUMANT22D1_HUMANBioGRID, MINT21900206 details
KPCI_HUMANTTHY_HUMANBioGRID, MINT21900206 details
KPCI_HUMANSOX2_HUMANIntAct24525231 details
KPCI_HUMANELF3_HUMANIntAct26977885 details
KPCI_HUMANNACC1_HUMANBioGRID, IntAct32296183 details
KPCI_HUMANGLI1_HUMANBioGRID, DIP23446420 30389910 details
KPCI_HUMANPDPK1_HUMANBioGRID, HPRD, IntAct10764742 31980649 details
KPCI_HUMANBAD_HUMANBioGRID15705582 details
KPCI_HUMANADAP1_HUMANBioGRID, HPRD12893243 details
KPCI_HUMANSMG1_HUMANBioGRID, HPRD8524286 details
KPCI_HUMANG3P_HUMANBioGRID, HPRD11724794 details
KPCI_HUMANFRS2_HUMANBioGRID, HPRD10383403 details
KPCI_HUMANVHL_HUMANBioGRID11574546 details
KPCI_HUMANIKKA_HUMANBioGRID, HPRD10022904 10848576 details
KPCI_HUMANIKKB_HUMANBioGRID10022904 details
KPCI_HUMANMBP_HUMANBioGRID, HPRD10383403 21315177 details
KPCI_HUMANCDK7_HUMANBioGRID21315177 details
KPCI_HUMANA4_HUMANBioGRID21832049 details
KPCI_HUMANSMUF1_HUMANBioGRID20804422 details
KPCI_HUMANUBC_HUMANBioGRID28190767 details
KPCI_HUMANRBM14_HUMANBioGRID30217970 details
KPCI_HUMANPCM1_HUMANBioGRID30217970 details
KPCI_HUMANCSKP_HUMANBioGRID30217970 details
KPCI_HUMANRFA2_HUMANBioGRID30217970 details
KPCI_HUMANCTBP1_HUMANBioGRID30217970 details
KPCI_HUMANFCG3A_HUMANBioGRID23024279 details
KPCI_HUMANCCNT1_HUMANBioGRID19208825 details
KPCI_HUMANTAU_HUMANBioGRID11104762 details
KPCI_HUMANMEOX2_HUMANBioGRID32296183 details
KPCI_HUMANRHOQ_HUMANHPRD10934474 details
KPCI_HUMANFRS3_HUMANHPRD10383403 details
KPCI_HUMANRAB2A_HUMANHPRD14570876 details
KPCI_HUMANKPCZ_HUMANBioGRID, IntAct, MINT11260256 24375676 25852190 28514442 29491746 31980649 details
KPCI_HUMAN1433F_HUMANBioGRID, HPRD, IntAct14676191 17979178 details
KPCI_HUMANMARK2_HUMANBioGRID, IntAct15324659 19615732 details
KPCI_HUMANHS90B_HUMANIntAct22939624 details
KPCI_HUMANDCAF7_HUMANBioGRID, IntAct27173435 unassigned1312 details
KPCI_HUMAN1433E_HUMANBioGRID, IntAct17979178 23472066 31980649 details
KPCI_HUMANRAB4A_HUMANBioGRID, HPRD12832475 details
KPCI_HUMANSFPQ_HUMANBioGRID20371701 details
KPCI_HUMANDUS1_HUMANBioGRID10022904 details
KPCI_HUMANZO1_HUMANBioGRID11257119 details
KPCI_HUMANRHG17_HUMANBioGRID16678097 details
KPCI_HUMANMP2K5_HUMANBioGRID12813044 details
KPCI_HUMANGAB1_HUMANBioGRID22883624 details
KPCI_HUMANRASH_HUMANBioGRID, HPRD10848576 30442766 details
KPCI_HUMANCNOT9_HUMANBioGRID29395067 details
KPCI_HUMANFAK1_HUMANBioGRID32158232 details
KPCI_HUMANASPP2_HUMANBioGRID30389910 details
KPCI_HUMANSRC_HUMANHPRD11713277 details
KPCI_HUMANIKBA_HUMANHPRD10848576 details
KPCI_HUMANMP2K1_HUMANHPRD10848576 details
KPCI_HUMANIRAK1_HUMANHPRD14684752 details
KPCI_HUMANANXA1_HUMANHPRD2457390 details
KPCI_HUMANUBP20_HUMANHPRD17350623 details