Entity Details

Primary name BRCC3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP46736
EntryNameBRCC3_HUMAN
FullNameLys-63-specific deubiquitinase BRCC36
TaxID9606
Evidenceevidence at protein level
Length316
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesBRCC3

GO terms

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GOName
GO:0000151 ubiquitin ligase complex
GO:0000152 nuclear ubiquitin ligase complex
GO:0000922 spindle pole
GO:0004843 thiol-dependent deubiquitinase
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006302 double-strand break repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0007049 cell cycle
GO:0008237 metallopeptidase activity
GO:0010165 response to X-ray
GO:0010212 response to ionizing radiation
GO:0016579 protein deubiquitination
GO:0030234 enzyme regulator activity
GO:0031593 polyubiquitin modification-dependent protein binding
GO:0045739 positive regulation of DNA repair
GO:0046872 metal ion binding
GO:0051301 cell division
GO:0070122 isopeptidase activity
GO:0070531 BRCA1-A complex
GO:0070536 protein K63-linked deubiquitination
GO:0070537 histone H2A K63-linked deubiquitination
GO:0070552 BRISC complex

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000555 JAB1/MPN/MOV34 metalloenzyme domainDomainDomain
IPR033860 Brcc36 isopeptidaseFamilyFamily
IPR037518 MPN domainDomainDomain
IPR040749 BRCC36, C-terminal helical domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB01593 ZincDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

29 interactions

InteractorPartnerSourcesPublicationsLink
BRCC3_HUMANSNPC5_HUMANBioGRID, HPRD, IntAct16189514 details
BRCC3_HUMANBABA2_HUMANBioGRID, IntAct14636569 17353931 19261746 19261748 19261749 19615732 20032457 20656689 21282113 30755420 details
BRCC3_HUMANUBC_HUMANBioGRID, MINT19202061 19214193 19261749 28190767 details
BRCC3_HUMANABRX2_HUMANBioGRID, IntAct19615732 20032457 20656690 21282113 22863883 24075985 25283148 26186194 26195665 28514442 30755420 31142841 33107021 details
BRCC3_HUMANGLYM_HUMANBioGRID, IntAct19615732 28514442 31253574 details
BRCC3_HUMANABRX1_HUMANBioGRID, DIP, IntAct18077395 19261746 19261748 19261749 19615732 20656689 20656690 21282113 22357538 24075985 details
BRCC3_HUMANUIMC1_HUMANBioGRID, DIP, IntAct17525341 18077395 19015238 19202061 19261746 19261748 19261749 19305427 19615732 20656689 21282113 23264621 details
BRCC3_HUMANBABA1_HUMANBioGRID, IntAct19261746 19261748 19261749 19615732 20032457 21282113 26186194 28514442 30755420 details
BRCC3_HUMANUB2D1_HUMANBioGRID14636569 details
BRCC3_HUMANSUMO2_HUMANBioGRID22689573 23211528 details
BRCC3_HUMANFANCG_HUMANBioGRID25132264 details
BRCC3_HUMANNUMA1_HUMANBioGRID26195665 details
BRCC3_HUMANWWP2_HUMANBioGRID25071155 31048545 33107021 details
BRCC3_HUMANINAR1_HUMANBioGRID24075985 details
BRCC3_HUMANANR11_HUMANBioGRID32296183 details
BRCC3_HUMANBRCA1_HUMANBioGRID, DIP, HPRD, UniProt14636569 17664283 19202061 19305427 22990118 25184681 25252691 29656893 details
BRCC3_HUMANTNIK_HUMANIntAct31413325 details
BRCC3_HUMANBARD1_HUMANBioGRID14636569 17525341 17664283 details
BRCC3_HUMANBRCA2_HUMANBioGRID14636569 17664283 details
BRCC3_HUMANRAD51_HUMANBioGRID14636569 details
BRCC3_HUMANP53_HUMANBioGRID14636569 details
BRCC3_HUMANCSN5_HUMANBioGRID19214193 details
BRCC3_HUMANBRCC3_HUMANBioGRID21282113 details
BRCC3_HUMANCRBN_HUMANBioGRID24292625 details
BRCC3_HUMANFANCJ_HUMANBioGRID17664283 details
BRCC3_HUMANCTNB1_HUMANBioGRID30323974 details
BRCC3_HUMANNLRP3_HUMANBioGRID30787184 31866999 details
BRCC3_HUMANSNAI1_HUMANBioGRID31911859 details
BRCC3_HUMANCDK5_HUMANBioGRID31787240 details