Entity Details

Primary name MRE11_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49959
EntryNameMRE11_HUMAN
FullNameDouble-strand break repair protein MRE11
TaxID9606
Evidenceevidence at protein level
Length708
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesMRE11

GO terms

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GOName
GO:0000014 single-stranded DNA endodeoxyribonuclease activity
GO:0000019 regulation of mitotic recombination
GO:0000723 telomere maintenance
GO:0000724 double-strand break repair via homologous recombination
GO:0000729 DNA double-strand break processing
GO:0000781 chromosome, telomeric region
GO:0003690 double-stranded DNA binding
GO:0004518 nuclease activity
GO:0004520 endodeoxyribonuclease activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006310 DNA recombination
GO:0006974 cellular response to DNA damage stimulus
GO:0007004 telomere maintenance via telomerase
GO:0007062 sister chromatid cohesion
GO:0007095 mitotic G2 DNA damage checkpoint signaling
GO:0007129 homologous chromosome pairing at meiosis
GO:0007131 reciprocal meiotic recombination
GO:0008022 protein C-terminus binding
GO:0008283 cell population proliferation
GO:0008296 3'-5'-exodeoxyribonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0008409 5'-3' exonuclease activity
GO:0016032 viral process
GO:0016605 PML body
GO:0030145 manganese ion binding
GO:0030870 Mre11 complex
GO:0031573 mitotic intra-S DNA damage checkpoint signaling
GO:0031860 telomeric 3' overhang formation
GO:0031954 positive regulation of protein autophosphorylation
GO:0032206 positive regulation of telomere maintenance
GO:0032481 positive regulation of type I interferon production
GO:0032508 DNA duplex unwinding
GO:0033674 positive regulation of kinase activity
GO:0035861 site of double-strand break
GO:0042138 meiotic DNA double-strand break formation
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0045296 cadherin binding
GO:0097552 mitochondrial double-strand break repair via homologous recombination
GO:0110025 DNA strand resection involved in replication fork processing
GO:1901796 regulation of signal transduction by p53 class mediator

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR003701 DNA double-strand break repair protein Mre11FamilyFamily
IPR004843 Calcineurin-like phosphoesterase domain, ApaH typeDomainDomain
IPR007281 Mre11, DNA-bindingDomainDomain
IPR029052 Metallo-dependent phosphatase-likeFamilyHomologous superfamily
IPR038487 Mre11, capping domainFamilyHomologous superfamily
IPR041796 Mre11 nuclease, N-terminal metallophosphatase domainDomainDomain

Diseases

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Interactions

74 interactions

InteractorPartnerSourcesPublicationsLink
MRE11_HUMANNEK1_HUMANBioGRID, HPRD, IntAct14690447 details
MRE11_HUMANNBN_HUMANBioGRID, DIP, HPRD, MINT, UniProt10426999 10783165 11062235 11238951 12419185 12447395 12607003 12679336 12750284 12861053 15734743 15758953 17500065 17612497 18458108 19244116 19270065 21884979 22078559 22231403 22464731 22939629 22941933 23530059 24413181 24981860 26455393 28363998 28369484 30179224 30440001 9705271 details
MRE11_HUMANMDC1_HUMANBioGRID, MINT, UniProt12607003 12607005 14519663 18583988 29656893 30179224 details
MRE11_HUMANFACD2_HUMANBioGRID, HPRD, MINT12447395 19609304 31180492 details
MRE11_HUMANCTIP_HUMANBioGRID, DIP, MINT21052091 22231403 25349192 25558984 26387952 26807646 27561354 31636387 details
MRE11_HUMANHD_HUMANIntAct17500595 details
MRE11_HUMANJIP2_HUMANBioGRID, IntAct25814554 details
MRE11_HUMANMRE11_HUMANBioGRID, DIP15734743 22078559 22231403 details
MRE11_HUMANBRCA1_HUMANBioGRID, UniProt10426999 10783165 11353843 11504724 16391231 17349954 23530059 24413181 25184681 29656893 details
MRE11_HUMANXRCC6_HUMANBioGRID, HPRD10508516 26344197 30585729 details
MRE11_HUMANATM_HUMANBioGRID, HPRD10608806 10783165 15758953 details
MRE11_HUMANATR_HUMANBioGRID10608806 details
MRE11_HUMANPRKDC_HUMANBioGRID10608806 details
MRE11_HUMANDNLI1_HUMANBioGRID, HPRD8530104 details
MRE11_HUMANRECQ5_HUMANBioGRID19270065 details
MRE11_HUMANSUMO2_HUMANBioGRID19394292 32786267 details
MRE11_HUMANFANCJ_HUMANBioGRID16391231 23530059 details
MRE11_HUMANSPOP_HUMANBioGRID28805822 details
MRE11_HUMANDYL1_HUMANBioGRID30464262 details
MRE11_HUMANCDK2_HUMANBioGRID22231403 details
MRE11_HUMANSUMO1_HUMANBioGRID32786267 details
MRE11_HUMANH2AX_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt12419185 15201865 16377563 18583988 19234442 22157895 31501894 details
MRE11_HUMANCCNE1_HUMANBioGRID, HPRD, UniProt12607005 details
MRE11_HUMANRAD50_HUMANBioGRID, DIP, HPRD, IntAct, MINT, UniProt10508516 10783165 10888888 11062235 11504724 12607003 12750284 15734743 16163361 16391231 17500065 17694070 19197236 19270065 22939629 23530059 24413181 24651726 24981860 26215093 26344197 26455393 27173435 28363998 28369484 30179224 30733337 31501894 8756642 9705271 unassigned1312 details
MRE11_HUMANATRX_HUMANBioGRID, UniProt23329831 24651726 27171262 details
MRE11_HUMANRAD17_HUMANMINT24534091 details
MRE11_HUMANCF161_HUMANBioGRID, IntAct27173435 unassigned1312 details
MRE11_HUMANTERF2_HUMANBioGRID, DIP10888888 18212065 19287395 22939629 details
MRE11_HUMANH31T_HUMANBioGRID, IntAct25823024 30021884 details
MRE11_HUMANBLM_HUMANBioGRID, IntAct10783165 28506294 29523790 details
MRE11_HUMANMLH1_HUMANBioGRID10783165 details
MRE11_HUMANMSH2_HUMANBioGRID10783165 details
MRE11_HUMANMSH6_HUMANBioGRID10783165 details
MRE11_HUMANRFC1_HUMANBioGRID10783165 details
MRE11_HUMANTE2IP_HUMANBioGRID15100233 15383534 22939629 details
MRE11_HUMANDDX1_HUMANBioGRID18710941 22863883 details
MRE11_HUMANATF2_HUMANBioGRID15916964 details
MRE11_HUMANANM1_HUMANBioGRID18285453 details
MRE11_HUMANNALP2_HUMANBioGRID18285453 28345663 details
MRE11_HUMANPAXI1_HUMANBioGRID17500065 details
MRE11_HUMANDCR1B_HUMANBioGRID18469862 details
MRE11_HUMANKAT5_HUMANBioGRID20070254 details
MRE11_HUMANEP300_HUMANBioGRID, HPRD16051665 details
MRE11_HUMANBARD1_HUMANBioGRID16391231 details
MRE11_HUMANSKP2_HUMANBioGRID22464731 details
MRE11_HUMANMDM2_HUMANBioGRID15734743 details
MRE11_HUMANDCR1C_HUMANBioGRID, HPRD15456891 31900314 details
MRE11_HUMANTRRAP_HUMANBioGRID23318449 details
MRE11_HUMANRNF8_HUMANBioGRID23115235 details
MRE11_HUMANRFA1_HUMANBioGRID18936170 24332808 30179224 details
MRE11_HUMANMDM4_HUMANBioGRID24608433 details
MRE11_HUMANSLX4_HUMANBioGRID25533185 details
MRE11_HUMANUBP4_HUMANBioGRID26455393 details
MRE11_HUMANSPTA1_HUMANBioGRID16889989 details
MRE11_HUMANHDAC6_HUMANBioGRID24882211 details
MRE11_HUMANTXNIP_HUMANBioGRID27437069 details
MRE11_HUMANMCM9_HUMANBioGRID26215093 details
MRE11_HUMANBIRC2_HUMANBioGRID28363998 details
MRE11_HUMANRN169_HUMANBioGRID30104380 details
MRE11_HUMANUBP7_HUMANBioGRID30179224 details
MRE11_HUMANRECQ4_HUMANBioGRID29229926 details
MRE11_HUMANP53_HUMANBioGRID15806145 24981860 details
MRE11_HUMANTRI29_HUMANBioGRID26095369 details
MRE11_HUMANTALAN_HUMANBioGRID23966166 details
MRE11_HUMANZN365_HUMANBioGRID23966166 details
MRE11_HUMANPPARG_HUMANBioGRID30699358 details
MRE11_HUMANUBQL4_HUMANBioGRID30612738 details
MRE11_HUMANCCNA2_HUMANBioGRID22231403 details
MRE11_HUMANPELI1_HUMANBioGRID30952868 details
MRE11_HUMANIFIX_HUMANBioGRID25665578 details
MRE11_HUMANNUPR1_HUMANBioGRID32780723 details
MRE11_HUMANTOP2A_HUMANBioGRID31967940 details
MRE11_HUMANERPG3_HUMANBioGRID31501894 details
MRE11_HUMANERCC6_HUMANBioGRID31501894 details