Entity Details

Primary name MMP14_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP50281
EntryNameMMP14_HUMAN
FullNameMatrix metalloproteinase-14
TaxID9606
Evidenceevidence at protein level
Length582
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesMMP14

GO terms

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GOName
GO:0001501 skeletal system development
GO:0001525 angiogenesis
GO:0001541 ovarian follicle development
GO:0001666 response to hypoxia
GO:0001935 endothelial cell proliferation
GO:0001958 endochondral ossification
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0005178 integrin binding
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005796 Golgi lumen
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005925 focal adhesion
GO:0006508 proteolysis
GO:0006979 response to oxidative stress
GO:0008270 zinc ion binding
GO:0008584 male gonad development
GO:0009612 response to mechanical stimulus
GO:0010831 positive regulation of myotube differentiation
GO:0010954 positive regulation of protein processing
GO:0014070 response to organic cyclic compound
GO:0016485 protein processing
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030307 positive regulation of cell growth
GO:0030324 lung development
GO:0030335 positive regulation of cell migration
GO:0030574 collagen catabolic process
GO:0031012 extracellular matrix
GO:0031410 cytoplasmic vesicle
GO:0031638 zymogen activation
GO:0035987 endodermal cell differentiation
GO:0035988 chondrocyte proliferation
GO:0042470 melanosome
GO:0043615 astrocyte cell migration
GO:0043627 response to estrogen
GO:0044354 macropinosome
GO:0045111 intermediate filament cytoskeleton
GO:0045579 positive regulation of B cell differentiation
GO:0045746 negative regulation of Notch signaling pathway
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048771 tissue remodeling
GO:0048870 cell motility
GO:0051895 negative regulation of focal adhesion assembly
GO:0060322 head development
GO:0070006 metalloaminopeptidase activity
GO:0097094 craniofacial suture morphogenesis
GO:1903076 regulation of protein localization to plasma membrane
GO:1905523 positive regulation of macrophage migration
GO:1990834 response to odorant

Subcellular Location

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Subcellular Location
Cytoplasm
Melanosome
Membrane

Domains

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DomainNameCategoryType
IPR000585 Hemopexin-like domainDomainDomain
IPR001818 Peptidase M10, metallopeptidaseDomainDomain
IPR002477 Peptidoglycan binding-likeDomainDomain
IPR006026 Peptidase, metallopeptidaseDomainDomain
IPR018486 Hemopexin, conserved siteSiteConserved site
IPR018487 Hemopexin-like repeatsRepeatRepeat
IPR021158 Peptidase M10A, cysteine switch, zinc binding siteSiteBinding site
IPR021190 Peptidase M10AFamilyFamily
IPR021805 Peptidase M10A, matrix metallopeptidase, C-terminalDomainDomain
IPR024079 Metallopeptidase, catalytic domain superfamilyFamilyHomologous superfamily
IPR033739 Peptidase M10A, catalytic domainDomainDomain
IPR036365 PGBD-like superfamilyFamilyHomologous superfamily
IPR036366 PGBD superfamilyFamilyHomologous superfamily
IPR036375 Hemopexin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00786 MarimastatDrugbanksmall molecule

Interactions

48 interactions

InteractorPartnerSourcesPublicationsLink
MMP14_HUMANC1QBP_HUMANBioGRID, HPRD, MINT11773076 12220632 details
MMP14_HUMANMTND_HUMANHPRD, UniProt14718544 details
MMP14_HUMANFURIN_HUMANBioGRID, IntAct, MINT20608975 21152186 8804434 details
MMP14_HUMANRAD_HUMANBioGRID, IntAct21988832 details
MMP14_HUMANPLLP_HUMANBioGRID, IntAct21988832 details
MMP14_HUMANTIMP2_HUMANBioGRID, HPRD, MINT24112707 8804434 9422789 9724659 details
MMP14_HUMANLUM_HUMANBioGRID, HPRD, MINT15466200 25304424 details
MMP14_HUMANKASH5_HUMANBioGRID, IntAct25416956 details
MMP14_HUMANZUP1_HUMANBioGRID, IntAct32296183 details
MMP14_HUMANDHB13_HUMANBioGRID, IntAct32296183 details
MMP14_HUMANSTOM_HUMANBioGRID, IntAct32296183 details
MMP14_HUMANEBP_HUMANBioGRID, IntAct32296183 details
MMP14_HUMANJAM1_HUMANBioGRID, IntAct32296183 details
MMP14_HUMANFHL3_HUMANBioGRID, IntAct32296183 details
MMP14_HUMANMSMO1_HUMANBioGRID, IntAct32296183 details
MMP14_HUMANAQP6_HUMANBioGRID, IntAct32296183 details
MMP14_HUMANELOV4_HUMANBioGRID, IntAct32296183 details
MMP14_HUMANTIMP1_HUMANBioGRID, IntAct26264872 32814053 8804434 details
MMP14_HUMANMMP3_HUMANBioGRID8804434 details
MMP14_HUMANTMM31_HUMANBioGRID32296183 details
MMP14_HUMANTGM2_HUMANBioGRID11278623 details
MMP14_HUMANBCAR1_HUMANBioGRID, HPRD, MINT18164686 details
MMP14_HUMANACTB_HUMANMINT18164686 details
MMP14_HUMANGORS2_HUMANMINT20608975 details
MMP14_HUMANGOGB1_HUMANMINT20608975 details
MMP14_HUMANTGON2_HUMANMINT20608975 details
MMP14_HUMANLIMK1_HUMANMolecular Connections21219645 details
MMP14_HUMANEGLN_HUMANIntAct22296769 details
MMP14_HUMANFGFR2_HUMANDIP20798051 details
MMP14_HUMANFGFR4_HUMANDIP20798051 details
MMP14_HUMANLRP1_HUMANBioGRID, HPRD14645246 details
MMP14_HUMANTICN3_HUMANBioGRID, HPRD11751414 details
MMP14_HUMANVPS35_HUMANBioGRID29891722 details
MMP14_HUMANCAV1_HUMANBioGRID, HPRD15466865 details
MMP14_HUMANCAH9_HUMANBioGRID28692057 details
MMP14_HUMANFBX6_HUMANBioGRID32409323 details
MMP14_HUMANTIMP3_HUMANHPRD8663332 details
MMP14_HUMANFA12_HUMANHPRD10930399 details
MMP14_HUMANMMP13_HUMANHPRD8663255 details
MMP14_HUMANKISS1_HUMANHPRD12879005 details
MMP14_HUMANCLD1_HUMANHPRD11382769 details
MMP14_HUMANTICN1_HUMANHPRD12810672 details
MMP14_HUMANITAV_HUMANHPRD11741954 details
MMP14_HUMANTIMP4_HUMANHPRD11178970 details
MMP14_HUMANSDC1_HUMANHPRD12464176 12904296 details
MMP14_HUMANMMP2_HUMANHPRD14583471 8663332 details
MMP14_HUMANPGCA_HUMANHPRD11854269 9688535 details
MMP14_HUMANCCL7_HUMANHPRD10947989 12149192 details