Entity Details

Primary name PDE1A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP54750
EntryNamePDE1A_HUMAN
FullNameCalcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
TaxID9606
Evidenceevidence at protein level
Length535
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-04-07

Ontological Relatives

GenesPDE1A

GO terms

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GOName
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
GO:0005516 calmodulin binding
GO:0005634 nucleus
GO:0005829 cytosol
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0034391 regulation of smooth muscle cell apoptotic process
GO:0043025 neuronal cell body
GO:0046069 cGMP catabolic process
GO:0046872 metal ion binding
GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity
GO:0048660 regulation of smooth muscle cell proliferation

Subcellular Location

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Domains

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DomainNameCategoryType
IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domainDomainDomain
IPR003607 HD/PDEase domainDomainDomain
IPR013706 3'5'-cyclic nucleotide phosphodiesterase N-terminalDomainDomain
IPR023088 3'5'-cyclic nucleotide phosphodiesteraseFamilyFamily
IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved siteSiteConserved site
IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00201 CaffeineDrugbanksmall molecule
DB00622 NicardipineDrugbanksmall molecule
DB01023 FelodipineDrugbanksmall molecule
DB01244 BepridilDrugbanksmall molecule
DB09283 TrapidilDrugbanksmall molecule