Entity Details

Primary name CASP7_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP55210
EntryNameCASP7_HUMAN
FullNameCaspase-7
TaxID9606
Evidenceevidence at protein level
Length303
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesCASP7

GO terms

Show/Hide Table
GOName
GO:0004197 cysteine-type endopeptidase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0072734 cellular response to staurosporine
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
GO:0097194 execution phase of apoptosis
GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR001309 Peptidase C14, p20 domainDomainDomain
IPR002138 Peptidase C14, caspase non-catalytic subunit p10DomainDomain
IPR002398 Peptidase C14 familyFamilyFamily
IPR015471 Caspase-3/7FamilyFamily
IPR015917 Peptidase C14A, caspase catalytic domainDomainDomain
IPR016129 Peptidase family C14A, His active siteSiteActive site
IPR029030 Caspase-like domain superfamilyFamilyHomologous superfamily
IPR033139 Peptidase family C14A, cysteine active siteSiteActive site

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB03384 FicaDrugbanksmall molecule
DB05408 EmricasanDrugbanksmall molecule
DB06255 Incadronic acidDrugbanksmall molecule

Interactions

81 interactions

InteractorPartnerSourcesPublicationsLink
CASP7_HUMANCASP7_HUMANBioGRID, HPRD, MINT11257230 11752425 18723680 details
CASP7_HUMANXIAP_HUMANBioGRID, HPRD, IntAct, MINT11257230 11257231 11257232 11359776 14512414 15200957 15580265 18521960 19698783 23074197 23979166 27927753 31467278 9230442 9384571 9525868 details
CASP7_HUMANBIRC2_HUMANBioGRID, HPRD, IntAct11084335 15580265 16339151 19258326 9384571 details
CASP7_HUMANNUCB2_HUMANMINT18154733 details
CASP7_HUMANRB_HUMANBioGRID, HPRD, IntAct11420704 15735701 19249677 details
CASP7_HUMANTNR1A_HUMANBioGRID, HPRD, MINT11755217 21157428 details
CASP7_HUMANPAK2_HUMANIntAct21555521 details
CASP7_HUMANSAT1_HUMANBioGRID, IntAct25416956 32296183 details
CASP7_HUMANTERF1_HUMANbhf-ucl, BioGRID21044950 details
CASP7_HUMANNIF3L_HUMANBioGRID, IntAct32296183 details
CASP7_HUMANMAGAB_HUMANBioGRID, IntAct32296183 details
CASP7_HUMANTEBP_HUMANBioGRID, DIP18723680 22451931 details
CASP7_HUMANCASP9_HUMANBioGRID, DIP18723680 details
CASP7_HUMANCASP6_HUMANDIP18723680 details
CASP7_HUMANGDIR2_HUMANDIP18723680 details
CASP7_HUMANPANX1_HUMANDIP20944749 32494015 details
CASP7_HUMANNF2L2_HUMANIntAct32911434 details
CASP7_HUMANHTRA4_HUMANIntAct31470122 details
CASP7_HUMANKLH36_HUMANIntAct32814053 details
CASP7_HUMANSKAP1_HUMANIntAct32814053 details
CASP7_HUMANP85A_HUMANIntAct32814053 details
CASP7_HUMANHD_HUMANIntAct32814053 details
CASP7_HUMANCASP2_HUMANBioGRID, HPRD11399776 details
CASP7_HUMANBIRC7_HUMANBioGRID, HPRD11024045 details
CASP7_HUMANBIRC5_HUMANBioGRID, HPRD11024045 11170436 9850056 details
CASP7_HUMANCASP8_HUMANBioGRID11832478 8962078 details
CASP7_HUMANBIRC3_HUMANBioGRID, HPRD16339151 30948266 9384571 details
CASP7_HUMANCASPA_HUMANBioGRID, HPRD8962078 details
CASP7_HUMANBIRC6_HUMANBioGRID15200957 15507451 details
CASP7_HUMANCSN6_HUMANBioGRID17337451 details
CASP7_HUMANSP1_HUMANBioGRID10103059 details
CASP7_HUMANTCPB_HUMANBioGRID23190606 details
CASP7_HUMANPA24B_HUMANBioGRID9875225 details
CASP7_HUMANPARP1_HUMANBioGRID18723680 22451931 9875225 details
CASP7_HUMANCLSPN_HUMANBioGRID, HPRD16123041 details
CASP7_HUMANGDIR1_HUMANBioGRID18723680 details
CASP7_HUMANVIME_HUMANBioGRID, HPRD10469173 11423904 11514563 18723680 details
CASP7_HUMANSPTN1_HUMANBioGRID18723680 details
CASP7_HUMANSTAT1_HUMANBioGRID18723680 details
CASP7_HUMANDFFA_HUMANBioGRID, HPRD10318789 18723680 details
CASP7_HUMANROCK1_HUMANBioGRID18723680 details
CASP7_HUMANCASP3_HUMANBioGRID18723680 details
CASP7_HUMANGRAB_HUMANBioGRID, HPRD17283187 8631895 details
CASP7_HUMANTAU_HUMANBioGRID, HPRD12888622 details
CASP7_HUMANIKKE_HUMANIntAct17353931 details
CASP7_HUMANASM_HUMANMINT21157428 details
CASP7_HUMANNEDD8_HUMANMINT22584050 details
CASP7_HUMANBIP_HUMANBioGRID, HPRD11943137 24080088 details
CASP7_HUMANCRYAB_HUMANBioGRID23049853 23074197 details
CASP7_HUMANBAX_HUMANBioGRID15254227 details
CASP7_HUMANATX3_HUMANBioGRID30455355 details
CASP7_HUMANE2AK2_HUMANHPRD11555640 details
CASP7_HUMANSRF_HUMANHPRD11387340 details
CASP7_HUMANRAD21_HUMANHPRD11875078 details
CASP7_HUMANMEF2A_HUMANHPRD11904443 details
CASP7_HUMANMEF2D_HUMANHPRD11904443 details
CASP7_HUMANPSN2_HUMANHPRD10069390 9219695 9990034 details
CASP7_HUMANNEDD4_HUMANHPRD9593687 details
CASP7_HUMANGOGA3_HUMANHPRD10791974 details
CASP7_HUMANPSIP1_HUMANHPRD12181742 details
CASP7_HUMANRBX2_HUMANHPRD10082581 details
CASP7_HUMANPSME3_HUMANHPRD11859414 details
CASP7_HUMANGORS1_HUMANHPRD11815631 details
CASP7_HUMANDCTN1_HUMANHPRD11425872 details
CASP7_HUMANUBE4B_HUMANHPRD11802788 details
CASP7_HUMANICAL_HUMANHPRD10731697 details
CASP7_HUMANPTMA_HUMANHPRD10675528 details
CASP7_HUMANRAD51_HUMANHPRD10998058 9607320 details
CASP7_HUMANCDC42_HUMANHPRD11278572 details
CASP7_HUMANLYN_HUMANHPRD12586738 details
CASP7_HUMANANDR_HUMANHPRD9535906 details
CASP7_HUMANRAC1_HUMANHPRD11278572 details
CASP7_HUMANCFLAR_HUMANHPRD9228018 details
CASP7_HUMANSTK24_HUMANHPRD12107159 details
CASP7_HUMANCATG_HUMANHPRD15650747 details
CASP7_HUMANKPCZ_HUMANHPRD11016947 details
CASP7_HUMANK1C18_HUMANHPRD9298992 details
CASP7_HUMANDESP_HUMANHPRD15500642 details
CASP7_HUMANRASA1_HUMANHPRD10200531 details
CASP7_HUMANPSN1_HUMANHPRD10069390 details
CASP7_HUMANMAX_HUMANHPRD11535131 details