Entity Details

Primary name DEF1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP59665
EntryNameDEF1_HUMAN
FullNameNeutrophil defensin 1
TaxID9606
Evidenceevidence at protein level
Length94
SequenceStatuscomplete
DateCreated2003-04-30
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0002227 innate immune response in mucosa
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005796 Golgi lumen
GO:0006935 chemotaxis
GO:0006955 immune response
GO:0010818 T cell chemotaxis
GO:0019730 antimicrobial humoral response
GO:0019731 antibacterial humoral response
GO:0030520 intracellular estrogen receptor signaling pathway
GO:0031640 killing of cells of other organism
GO:0035578 azurophil granule lumen
GO:0042832 defense response to protozoan
GO:0043312 neutrophil degranulation
GO:0044657 pore formation in membrane of other organism during symbiotic interaction
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0050832 defense response to fungus
GO:0051607 defense response to virus
GO:0051673 membrane disruption in other organism
GO:0051873 killing by host of symbiont cells
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0071222 cellular response to lipopolysaccharide

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR002366 Defensin propeptideDomainDomain
IPR006080 Beta/alpha defensinDomainDomain
IPR006081 Alpha-defensinDomainDomain
IPR016327 Alpha-defensin propeptideFamilyFamily

Diseases

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