Entity Details

Primary name RAP1A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP62834
EntryNameRAP1A_HUMAN
FullNameRas-related protein Rap-1A
TaxID9606
Evidenceevidence at protein level
Length184
SequenceStatuscomplete
DateCreated2004-08-16
DateModified2021-06-02

Ontological Relatives

GenesRAP1A

GO terms

Show/Hide Table
GOName
GO:0000186 obsolete activation of MAPKK activity
GO:0002250 adaptive immune response
GO:0003924 GTPase activity
GO:0003925 G protein activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005525 GTP binding
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007399 nervous system development
GO:0009743 response to carbohydrate
GO:0010008 endosome membrane
GO:0010976 positive regulation of neuron projection development
GO:0019003 GDP binding
GO:0030054 cell junction
GO:0031267 small GTPase binding
GO:0032045 guanyl-nucleotide exchange factor complex
GO:0032486 Rap protein signal transduction
GO:0032966 negative regulation of collagen biosynthetic process
GO:0035579 specific granule membrane
GO:0035690 cellular response to drug
GO:0038180 nerve growth factor signaling pathway
GO:0043005 neuron projection
GO:0043312 neutrophil degranulation
GO:0043547 positive regulation of GTPase activity
GO:0044877 protein-containing complex binding
GO:0045335 phagocytic vesicle
GO:0045860 positive regulation of protein kinase activity
GO:0046326 positive regulation of glucose import
GO:0048471 perinuclear region of cytoplasm
GO:0050796 regulation of insulin secretion
GO:0061028 establishment of endothelial barrier
GO:0070062 extracellular exosome
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071320 cellular response to cAMP
GO:0072659 protein localization to plasma membrane
GO:0097327 response to antineoplastic agent
GO:0097421 liver regeneration
GO:0098696 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
GO:0098978 glutamatergic synapse
GO:1901888 regulation of cell junction assembly
GO:1905451 positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
GO:1990090 cellular response to nerve growth factor stimulus
GO:2000301 negative regulation of synaptic vesicle exocytosis
GO:2001214 positive regulation of vasculogenesis

Subcellular Location

Show/Hide Table
Subcellular Location
Cell junction
Cell membrane
Cytoplasm
Early endosome

Domains

Show/Hide Table
DomainNameCategoryType
IPR001806 Small GTPaseFamilyFamily
IPR005225 Small GTP-binding protein domainDomainDomain
IPR020849 Small GTPase, Ras-typeFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR038851 Ras-related protein Rap1FamilyFamily

Diseases

Show/Hide Table

Interactions

53 interactions

InteractorPartnerSourcesPublicationsLink
RAP1A_HUMANRASF5_HUMANUniProt12845325 15569673 details
RAP1A_HUMANRAF1_HUMANBioGRID, HPRD, IntAct10454553 7791872 7862125 8756332 9115221 9564038 9867809 details
RAP1A_HUMANGNDS_HUMANBioGRID, HPRD, IntAct10085114 10922060 11786539 23236378 details
RAP1A_HUMANHDAC1_HUMANBioGRID, HPRD15207703 details
RAP1A_HUMANTNR6_HUMANBioGRID, HPRD, IntAct15207703 25241761 details
RAP1A_HUMANRPGF2_HUMANBioGRID, HPRD, UniProt10608844 10608883 10934204 details
RAP1A_HUMANRPGF4_HUMANBioGRID10777494 details
RAP1A_HUMANRPGF5_HUMANBioGRID, HPRD10777494 10934204 details
RAP1A_HUMANBIN1_HUMANBioGRID, HPRD15207703 details
RAP1A_HUMANGDS1_HUMANBioGRID, HPRD, IntAct11948427 20709748 28514442 details
RAP1A_HUMANRGDSR_HUMANBioGRID, HPRD12874025 details
RAP1A_HUMANARHG1_HUMANBioGRID12581858 details
RAP1A_HUMANRPGF6_HUMANBioGRID, HPRD11524421 12581858 details
RAP1A_HUMANRPGF1_HUMANBioGRID, DIP22081014 9266971 details
RAP1A_HUMANPDE6D_HUMANBioGRID, HPRD, UniProt11786539 11980706 30257685 details
RAP1A_HUMANTR10C_HUMANBioGRID, HPRD15207703 details
RAP1A_HUMANAB1IP_HUMANHPRD15469846 details
RAP1A_HUMANELOA1_HUMANBioGRID, HPRD15207703 details
RAP1A_HUMANFADD_HUMANBioGRID, HPRD15207703 details
RAP1A_HUMANRAIN_HUMANHPRD15031288 details
RAP1A_HUMANAFAD_HUMANBioGRID10922060 details
RAP1A_HUMANKRIT1_HUMANBioGRID, HPRD9285558 details
RAP1A_HUMANFAF1_HUMANBioGRID, HPRD15207703 details
RAP1A_HUMAN1433Z_HUMANIntAct23622247 details
RAP1A_HUMANBMX_HUMANBioGRID, HPRD15207703 details
RAP1A_HUMANGANAB_HUMANBioGRID, IntAct21988832 details
RAP1A_HUMANPRAF1_HUMANHPRD11335720 details
RAP1A_HUMANBRAF_HUMANBioGRID, HPRD10454553 16507992 9560161 details
RAP1A_HUMANRUN3A_HUMANBioGRID9523700 details
RAP1A_HUMANRPGP1_HUMANBioGRID12842888 details
RAP1A_HUMANRGS14_HUMANBioGRID, HPRD10926822 details
RAP1A_HUMANGBRL2_HUMANBioGRID12581858 details
RAP1A_HUMANHSP74_HUMANBioGRID15207703 details
RAP1A_HUMANRPGF3_HUMANBioGRID10777494 details
RAP1A_HUMANSMCA2_HUMANBioGRID15207703 details
RAP1A_HUMANTSC2_HUMANBioGRID12147258 12842888 details
RAP1A_HUMANMTOR_HUMANBioGRID15854902 details
RAP1A_HUMANNTRK1_HUMANBioGRID, HPRD11466412 details
RAP1A_HUMANTRM7_HUMANIntAct17353931 details
RAP1A_HUMANSIR1_HUMANBioGRID18235501 details
RAP1A_HUMANTRAF6_HUMANIntAct17353931 details
RAP1A_HUMANGRP4_HUMANBioGRID, HPRD, IntAct11880369 25241761 details
RAP1A_HUMANDGKI_HUMANBioGRID15894621 details
RAP1A_HUMANRAP1A_HUMANHPRD10224125 7791872 details
RAP1A_HUMANKAPCA_HUMANHPRD9867809 details
RAP1A_HUMANRASA3_HUMANHPRD2158984 details
RAP1A_HUMANVHL_HUMANIntAct17353931 details
RAP1A_HUMANRASA1_HUMANHPRD2164710 details
RAP1A_HUMANHS71B_HUMANHPRD15207703 details
RAP1A_HUMANGBB1_HUMANBioGRID20048162 details
RAP1A_HUMANRADIL_HUMANBioGRID20048162 details
RAP1A_HUMANRHEB_HUMANBioGRID15854902 details
RAP1A_HUMANHS71A_HUMANHPRD15207703 details