Entity Details

Primary name JAG1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP78504
EntryNameJAG1_HUMAN
FullNameProtein jagged-1
TaxID9606
Evidenceevidence at protein level
Length1218
SequenceStatuscomplete
DateCreated2002-05-02
DateModified2021-06-02

Ontological Relatives

GenesJAG1

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001709 cell fate determination
GO:0001953 negative regulation of cell-matrix adhesion
GO:0001974 blood vessel remodeling
GO:0002011 morphogenesis of an epithelial sheet
GO:0002456 T cell mediated immunity
GO:0003180 aortic valve morphogenesis
GO:0003184 pulmonary valve morphogenesis
GO:0003215 cardiac right ventricle morphogenesis
GO:0005112 Notch binding
GO:0005198 structural molecule activity
GO:0005509 calcium ion binding
GO:0005543 phospholipid binding
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005912 adherens junction
GO:0007219 Notch signaling pathway
GO:0007399 nervous system development
GO:0008083 growth factor activity
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0022408 negative regulation of cell-cell adhesion
GO:0030097 hemopoiesis
GO:0030216 keratinocyte differentiation
GO:0030336 negative regulation of cell migration
GO:0032495 response to muramyl dipeptide
GO:0035909 aorta morphogenesis
GO:0042127 regulation of cell population proliferation
GO:0042491 inner ear auditory receptor cell differentiation
GO:0045445 myoblast differentiation
GO:0045446 endothelial cell differentiation
GO:0045599 negative regulation of fat cell differentiation
GO:0045602 negative regulation of endothelial cell differentiation
GO:0045639 positive regulation of myeloid cell differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045747 positive regulation of Notch signaling pathway
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0060411 cardiac septum morphogenesis
GO:0061073 ciliary body morphogenesis
GO:0061156 pulmonary artery morphogenesis
GO:0061309 cardiac neural crest cell development involved in outflow tract morphogenesis
GO:0061314 Notch signaling involved in heart development
GO:0061444 endocardial cushion cell development
GO:0062043 positive regulation of cardiac epithelial to mesenchymal transition
GO:0072006 nephron development
GO:0072015 glomerular visceral epithelial cell development
GO:0072017 distal tubule development
GO:0072070 loop of Henle development
GO:0097150 neuronal stem cell population maintenance
GO:2000737 negative regulation of stem cell differentiation

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000742 EGF-like domainDomainDomain
IPR001007 VWFC domainDomainDomain
IPR001774 Delta/Serrate/lag-2 (DSL) proteinDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011651 Notch ligand, N-terminal domainDomainDomain
IPR013032 EGF-like, conserved siteSiteConserved site
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR026219 Jagged/Serrate proteinFamilyFamily
IPR033108 Protein jagged-1FamilyFamily

Diseases

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