Entity Details

Primary name FMO1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ01740
EntryNameFMO1_HUMAN
FullNameDimethylaniline monooxygenase [N-oxide-forming] 1
TaxID9606
Evidenceevidence at protein level
Length532
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesFMO1

GO terms

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GOName
GO:0004497 monooxygenase activity
GO:0004499 N,N-dimethylaniline monooxygenase activity
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
GO:0006082 organic acid metabolic process
GO:0006805 xenobiotic metabolic process
GO:0006970 response to osmotic stress
GO:0009404 toxin metabolic process
GO:0016021 integral component of membrane
GO:0017144 drug metabolic process
GO:0032496 response to lipopolysaccharide
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
GO:0070995 NADPH oxidation

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Microsome membrane

Domains

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DomainNameCategoryType
IPR000960 Flavin monooxygenase FMOFamilyFamily
IPR002253 Flavin monooxygenase (FMO) 1FamilyFamily
IPR020946 Flavin monooxygenase-likeFamilyFamily
IPR036188 FAD/NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00185 CevimelineDrugbanksmall molecule
DB00501 CimetidineDrugbanksmall molecule
DB00582 VoriconazoleDrugbanksmall molecule
DB00675 TamoxifenDrugbanksmall molecule
DB00768 OlopatadineDrugbanksmall molecule
DB04871 LorcaserinDrugbanksmall molecule
DB05294 VandetanibDrugbanksmall molecule
DB12278 PropiverineDrugbanksmall molecule
DB13609 UmifenovirSwissprotsmall molecule
DB15305 RisdiplamSwissprotsmall molecule

Interactions

6 interactions

InteractorPartnerSourcesPublicationsLink
FMO1_HUMANLERL1_HUMANBioGRID, IntAct32296183 details
FMO1_HUMANLFG1_HUMANBioGRID, IntAct32296183 details
FMO1_HUMANREEP4_HUMANBioGRID, IntAct32296183 details
FMO1_HUMANMF14B_HUMANBioGRID, IntAct32296183 details
FMO1_HUMANSOAT_HUMANBioGRID, IntAct32296183 details
FMO1_HUMANCREB3_HUMANBioGRID, IntAct25910212 details