Entity Details

Primary name PYRD_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ02127
EntryNamePYRD_HUMAN
FullNameDihydroorotate dehydrogenase (quinone), mitochondrial
TaxID9606
Evidenceevidence at protein level
Length395
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesDHODH

GO terms

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GOName
GO:0004152 dihydroorotate dehydrogenase activity
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005829 cytosol
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0007565 female pregnancy
GO:0007595 lactation
GO:0009220 pyrimidine ribonucleotide biosynthetic process
GO:0010181 FMN binding
GO:0016021 integral component of membrane
GO:0031000 response to caffeine
GO:0042493 response to drug
GO:0042594 response to starvation
GO:0043025 neuronal cell body
GO:0043065 positive regulation of apoptotic process
GO:0044205 'de novo' UMP biosynthetic process
GO:0046134 pyrimidine nucleoside biosynthetic process
GO:0048039 ubiquinone binding
GO:0090140 regulation of mitochondrial fission
GO:1903576 response to L-arginine

Subcellular Location

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Subcellular Location
Mitochondrion inner membrane

Domains

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DomainNameCategoryType
IPR001295 Dihydroorotate dehydrogenase, conserved siteSiteConserved site
IPR005719 Dihydroorotate dehydrogenase, class 2FamilyFamily
IPR005720 Dihydroorotate dehydrogenase domainDomainDomain
IPR013785 Aldolase-type TIM barrelFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01097 LeflunomideDrugbanksmall molecule
DB01117 AtovaquoneDrugbanksmall molecule
DB02262 Orotic acidDrugbanksmall molecule
DB02613 Capric dimethyl amine oxideDrugbanksmall molecule
DB03247 Flavin mononucleotideDrugbanksmall molecule
DB03480 Brequinar AnalogDrugbanksmall molecule
DB03523 BrequinarDrugbanksmall molecule
DB04147 Dodecyldimethylamine N-oxideDrugbanksmall molecule
DB04281 2-[4-(4-Chlorophenyl)Cyclohexylidene]-3,4-Dihydroxy-1(2h)-NaphthalenoneDrugbanksmall molecule
DB04583 5-Carbamoyl-1,1':4',1''-terphenyl-3-carboxylic acidDrugbanksmall molecule
DB05125 SC12267Drugbanksmall molecule
DB06481 ManitimusDrugbanksmall molecule
DB07443 (2Z)-N-biphenyl-4-yl-2-cyano-3-hydroxybut-2-enamideDrugbanksmall molecule
DB07559 (2Z)-2-cyano-N-(2,2'-dichlorobiphenyl-4-yl)-3-hydroxybut-2-enamideDrugbanksmall molecule
DB07561 (2Z)-2-cyano-N-(3'-ethoxybiphenyl-4-yl)-3-hydroxybut-2-enamideDrugbanksmall molecule
DB07646 UNDECYLAMINE-N,N-DIMETHYL-N-OXIDEDrugbanksmall molecule
DB07975 2-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENT-1-ENE-1-CARBOXYLIC ACIDDrugbanksmall molecule
DB07976 3-{[(3-FLUORO-3'-METHOXYBIPHENYL-4-YL)AMINO]CARBONYL}THIOPHENE-2-CARBOXYLIC ACIDDrugbanksmall molecule
DB07977 3-({[3,5-DIFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)THIOPHENE-2-CARBOXYLIC ACIDDrugbanksmall molecule
DB07978 2-({[2,3,5,6-TETRAFLUORO-3'-(TRIFLUOROMETHOXY)BIPHENYL-4-YL]AMINO}CARBONYL)CYCLOPENTA-1,3-DIENE-1-CARBOXYLIC ACIDDrugbanksmall molecule
DB08006 N-anthracen-2-yl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amineDrugbanksmall molecule
DB08008 5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amineDrugbanksmall molecule
DB08169 (2Z)-N-biphenyl-4-yl-2-cyano-3-cyclopropyl-3-hydroxyprop-2-enamideDrugbanksmall molecule
DB08172 (2Z)-N-(3-chloro-2'-methoxybiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamideDrugbanksmall molecule
DB08249 3,6,9,12,15-PENTAOXATRICOSAN-1-OLDrugbanksmall molecule
DB08880 TeriflunomideDrugbanksmall molecule

Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
PYRD_HUMANMT2_HUMANBioGRID, IntAct21988832 details
PYRD_HUMANTMEDA_HUMANBioGRID, IntAct21988832 details
PYRD_HUMANTTPA_HUMANBioGRID, IntAct32296183 details
PYRD_HUMANRN19B_HUMANBioGRID, IntAct32296183 details