Entity Details

Primary name NOTC2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ04721
EntryNameNOTC2_HUMAN
FullNameNeurogenic locus notch homolog protein 2
TaxID9606
Evidenceevidence at protein level
Length2471
SequenceStatuscomplete
DateCreated2002-03-27
DateModified2021-06-02

Ontological Relatives

GenesNOTCH2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000139 Golgi membrane
GO:0001701 in utero embryonic development
GO:0001709 cell fate determination
GO:0001947 heart looping
GO:0002011 morphogenesis of an epithelial sheet
GO:0002315 marginal zone B cell differentiation
GO:0002437 inflammatory response to antigenic stimulus
GO:0003162 atrioventricular node development
GO:0003184 pulmonary valve morphogenesis
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005929 cilium
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006915 apoptotic process
GO:0006959 humoral immune response
GO:0007219 Notch signaling pathway
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0009887 animal organ morphogenesis
GO:0009986 cell surface
GO:0010629 negative regulation of gene expression
GO:0010838 positive regulation of keratinocyte proliferation
GO:0016020 membrane
GO:0019827 stem cell population maintenance
GO:0019899 enzyme binding
GO:0030097 hemopoiesis
GO:0030326 embryonic limb morphogenesis
GO:0030513 positive regulation of BMP signaling pathway
GO:0035264 multicellular organism growth
GO:0035622 intrahepatic bile duct development
GO:0038023 signaling receptor activity
GO:0042060 wound healing
GO:0042742 defense response to bacterium
GO:0043011 myeloid dendritic cell differentiation
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043235 receptor complex
GO:0045672 positive regulation of osteoclast differentiation
GO:0045967 negative regulation of growth rate
GO:0046579 positive regulation of Ras protein signal transduction
GO:0046849 bone remodeling
GO:0051059 NF-kappaB binding
GO:0060413 atrial septum morphogenesis
GO:0060674 placenta blood vessel development
GO:0061073 ciliary body morphogenesis
GO:0061314 Notch signaling involved in heart development
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070986 left/right axis specification
GO:0072014 proximal tubule development
GO:0072015 glomerular visceral epithelial cell development
GO:0072104 glomerular capillary formation
GO:0072574 hepatocyte proliferation
GO:1990705 cholangiocyte proliferation
GO:2000249 regulation of actin cytoskeleton reorganization
GO:2001204 regulation of osteoclast development

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000742 EGF-like domainDomainDomain
IPR000800 Notch domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR002110 Ankyrin repeatRepeatRepeat
IPR008297 NotchFamilyFamily
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR010660 Notch, NOD domainDomainDomain
IPR011656 Notch, NODP domainDomainDomain
IPR013032 EGF-like, conserved siteSiteConserved site
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR020683 Ankyrin repeat-containing domainDomainDomain
IPR022336 Neurogenic locus Notch 2FamilyFamily
IPR024600 Domain of unknown function DUF3454, notchDomainDomain
IPR035993 Notch-like domain superfamilyFamilyHomologous superfamily
IPR036770 Ankyrin repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

36 interactions

InteractorPartnerSourcesPublicationsLink
NOTC2_HUMANSMAD1_HUMANBioGRID, HPRD, MINT15231748 details
NOTC2_HUMANCRKL_HUMANBioGRID, IntAct18654987 details
NOTC2_HUMANANR28_HUMANBioGRID, IntAct23414517 24255178 details
NOTC2_HUMANCYTM_HUMANBioGRID, MINT25640309 details
NOTC2_HUMANESIP1_HUMANBioGRID, MINT25640309 details
NOTC2_HUMANLRAT2_HUMANBioGRID, MINT25640309 details
NOTC2_HUMANI13R2_HUMANBioGRID, MINT25640309 details
NOTC2_HUMANIL24_HUMANBioGRID, MINT25640309 details
NOTC2_HUMANITIH5_HUMANBioGRID, MINT25640309 details
NOTC2_HUMANKLK5_HUMANBioGRID, MINT25640309 details
NOTC2_HUMANMTA3_HUMANBioGRID, MINT25640309 details
NOTC2_HUMANHOP2_HUMANBioGRID, MINT25640309 details
NOTC2_HUMANST14_HUMANBioGRID, MINT25640309 details
NOTC2_HUMANSUH_HUMANBioGRID, HPRD, IntAct, MINT25609649 26186194 26496610 28514442 9032325 details
NOTC2_HUMANCCR2_HUMANBioGRID, MINT28298427 details
NOTC2_HUMANGSK3B_HUMANBioGRID, HPRD12794074 details
NOTC2_HUMANJAG1_HUMANBioGRID, HPRD10551863 10958687 11346656 details
NOTC2_HUMANDLL1_HUMANBioGRID, HPRD10958687 11346656 9244302 details
NOTC2_HUMANMAML1_HUMANBioGRID, HPRD11101851 details
NOTC2_HUMANJAG2_HUMANBioGRID, HPRD10958687 details
NOTC2_HUMANMYOC_HUMANBioGRID, HPRD16289162 details
NOTC2_HUMANEGFL7_HUMANBioGRID19503073 details
NOTC2_HUMANDTX3_HUMANBioGRID31854042 details
NOTC2_HUMANSHAN3_HUMANMINT21653829 details
NOTC2_HUMANCNTN1_HUMANBioGRID, HPRD14567914 details
NOTC2_HUMANCASR_HUMANBioGRID17573339 details
NOTC2_HUMANST7_HUMANBioGRID29395067 details
NOTC2_HUMANSMAP2_HUMANBioGRID29395067 details
NOTC2_HUMANDTX3L_HUMANBioGRID31854042 details
NOTC2_HUMANLFNG_HUMANHPRD11346656 details
NOTC2_HUMANMFNG_HUMANHPRD11346656 details
NOTC2_HUMANDTX1_HUMANHPRD9244302 details
NOTC2_HUMANPSN1_HUMANHPRD11518718 details
NOTC2_HUMANPSN2_HUMANHPRD11518718 details
NOTC2_HUMANMAML2_HUMANHPRD12370315 details
NOTC2_HUMANMAML3_HUMANHPRD12370315 details