Entity Details

Primary name DPOE1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ07864
EntryNameDPOE1_HUMAN
FullNameDNA polymerase epsilon catalytic subunit A
TaxID9606
Evidenceevidence at protein level
Length2286
SequenceStatuscomplete
DateCreated1994-10-01
DateModified2021-06-02

Ontological Relatives

GenesPOLE

GO terms

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GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000166 nucleotide binding
GO:0000278 mitotic cell cycle
GO:0000731 DNA synthesis involved in DNA repair
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005886 plasma membrane
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
GO:0006272 leading strand elongation
GO:0006287 base-excision repair, gap-filling
GO:0006297 nucleotide-excision repair, DNA gap filling
GO:0008270 zinc ion binding
GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity
GO:0008622 epsilon DNA polymerase complex
GO:0045004 DNA replication proofreading
GO:0048568 embryonic organ development
GO:0051539 4 iron, 4 sulfur cluster binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR006133 DNA-directed DNA polymerase, family B, exonuclease domainDomainDomain
IPR006134 DNA-directed DNA polymerase, family B, multifunctional domainDomainDomain
IPR006172 DNA-directed DNA polymerase, family BFamilyFamily
IPR012337 Ribonuclease H-like superfamilyFamilyHomologous superfamily
IPR013697 DNA polymerase epsilon, catalytic subunit A, C-terminalDomainDomain
IPR029703 DNA polymerase epsilon catalytic subunitFamilyFamily
IPR036397 Ribonuclease H superfamilyFamilyHomologous superfamily
IPR042087 DNA polymerase family B, thumb domainFamilyHomologous superfamily
IPR043502 DNA/RNA polymerase superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00242 CladribineDrugbanksmall molecule