Entity Details

Primary name DYHC1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14204
EntryNameDYHC1_HUMAN
FullNameCytoplasmic dynein 1 heavy chain 1
TaxID9606
Evidenceevidence at protein level
Length4646
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesDYNC1H1

GO terms

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GOName
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0003723 RNA binding
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005868 cytoplasmic dynein complex
GO:0005874 microtubule
GO:0005881 cytoplasmic microtubule
GO:0005938 cell cortex
GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport
GO:0007018 microtubule-based movement
GO:0007052 mitotic spindle organization
GO:0007097 nuclear migration
GO:0008090 retrograde axonal transport
GO:0008569 minus-end-directed microtubule motor activity
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0016020 membrane
GO:0019058 viral life cycle
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0030286 dynein complex
GO:0031122 cytoplasmic microtubule organization
GO:0032388 positive regulation of intracellular transport
GO:0033962 P-body assembly
GO:0034063 stress granule assembly
GO:0035578 azurophil granule lumen
GO:0035973 aggrephagy
GO:0043312 neutrophil degranulation
GO:0045505 dynein intermediate chain binding
GO:0051293 establishment of spindle localization
GO:0051301 cell division
GO:0051959 dynein light intermediate chain binding
GO:0060236 regulation of mitotic spindle organization
GO:0070062 extracellular exosome
GO:0072382 minus-end-directed vesicle transport along microtubule
GO:0090235 regulation of metaphase plate congression
GO:0097711 ciliary basal body-plasma membrane docking
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1904115 axon cytoplasm
GO:1905832 positive regulation of spindle assembly

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR003593 AAA+ ATPase domainDomainDomain
IPR004273 Dynein heavy chain region D6 P-loop domainDomainDomain
IPR013594 Dynein heavy chain, tailDomainDomain
IPR013602 Dynein heavy chain, linkerDomainDomain
IPR024317 Dynein heavy chain, AAA module D4DomainDomain
IPR024743 Dynein heavy chain, coiled coil stalkDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR035699 Dynein heavy chain, hydrolytic ATP-binding dynein motor regionDomainDomain
IPR035706 Dynein heavy chain, ATP-binding dynein motor regionDomainDomain
IPR041228 Dynein heavy chain, C-terminal domainDomainDomain
IPR041466 Dynein heavy chain, AAA 5 extension domainDomainDomain
IPR041658 Dynein heavy chain AAA lid domainDomainDomain
IPR042219 Dynein heavy chain AAA lid domain superfamilyFamilyHomologous superfamily
IPR042222 Dynein heavy chain, domain 2, N-terminalFamilyHomologous superfamily
IPR042228 Dynein heavy chain, linker, subdomain 3FamilyHomologous superfamily
IPR043157 Dynein heavy chain, AAA1 domain, small subdomainFamilyHomologous superfamily
IPR043160 Dynein heavy chain, C-terminal domain, barrel regionFamilyHomologous superfamily

Diseases

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Interactions

109 interactions

InteractorPartnerSourcesPublicationsLink
DYHC1_HUMANDISC1_HUMANBioGRID, IntAct17043677 31413325 details
DYHC1_HUMANPSN2_HUMANBioGRID, IntAct21163940 details
DYHC1_HUMANDYHC1_HUMANMINT21723285 details
DYHC1_HUMANEGFR_HUMANBioGRID, IntAct20029029 31980649 details
DYHC1_HUMANZNF16_HUMANUniProt21874239 details
DYHC1_HUMANHD_HUMANDIP, IntAct17500595 17548833 32814053 details
DYHC1_HUMANSYUA_HUMANBioGRID, IntAct17893145 26496610 details
DYHC1_HUMANLIS1_HUMANBioGRID, IntAct11889140 12885786 18784752 19622634 26344197 26496610 27173435 34079125 unassigned1312 details
DYHC1_HUMANHNRPQ_HUMANBioGRID, IntAct26496610 32814053 details
DYHC1_HUMANMTR1B_HUMANBioGRID, IntAct26514267 details
DYHC1_HUMANDUX4_HUMANBioGRID, IntAct26816005 details
DYHC1_HUMANKTNB1_HUMANBioGRID, IntAct16203747 26929214 details
DYHC1_HUMANTNIK_HUMANBioGRID, IntAct17043677 31413325 details
DYHC1_HUMANRPAB1_HUMANIntAct32814053 details
DYHC1_HUMANOTX2_HUMANIntAct32814053 details
DYHC1_HUMANNTF3_HUMANIntAct32814053 details
DYHC1_HUMANNGN1_HUMANIntAct32814053 details
DYHC1_HUMANMYPT2_HUMANIntAct32814053 details
DYHC1_HUMANM3K5_HUMANIntAct32814053 details
DYHC1_HUMANIL16_HUMANIntAct32814053 details
DYHC1_HUMANGA45A_HUMANIntAct32814053 details
DYHC1_HUMANCATH_HUMANIntAct32814053 details
DYHC1_HUMANCRBB3_HUMANIntAct32814053 details
DYHC1_HUMANCOF2_HUMANIntAct32814053 details
DYHC1_HUMANCDK8_HUMANIntAct32814053 details
DYHC1_HUMANASPH_HUMANIntAct32814053 details
DYHC1_HUMANLEG9C_HUMANIntAct32814053 details
DYHC1_HUMANSPT46_HUMANIntAct32814053 details
DYHC1_HUMANTMPS6_HUMANIntAct32814053 details
DYHC1_HUMANPBIR3_HUMANIntAct32814053 details
DYHC1_HUMANATP23_HUMANIntAct32814053 details
DYHC1_HUMANZHX1R_HUMANIntAct32814053 details
DYHC1_HUMANBEX2_HUMANIntAct32814053 details
DYHC1_HUMANDCNL5_HUMANIntAct32814053 details
DYHC1_HUMANPRAM_HUMANIntAct32814053 details
DYHC1_HUMANTMTC1_HUMANIntAct32814053 details
DYHC1_HUMANFA2H_HUMANIntAct32814053 details
DYHC1_HUMANRTP4_HUMANIntAct32814053 details
DYHC1_HUMANTEX12_HUMANIntAct32814053 details
DYHC1_HUMANWBP1L_HUMANIntAct32814053 details
DYHC1_HUMANSCAPE_HUMANIntAct32814053 details
DYHC1_HUMANARFG3_HUMANIntAct32814053 details
DYHC1_HUMANDUS10_HUMANIntAct32814053 details
DYHC1_HUMANWDR5_HUMANIntAct32814053 details
DYHC1_HUMANWWP2_HUMANIntAct32814053 details
DYHC1_HUMANTI17B_HUMANIntAct32814053 details
DYHC1_HUMANBZW1_HUMANIntAct32814053 details
DYHC1_HUMANBAG3_HUMANIntAct32814053 details
DYHC1_HUMANEI2BE_HUMANIntAct32814053 details
DYHC1_HUMANTELT_HUMANIntAct32814053 details
DYHC1_HUMANRXRG_HUMANIntAct32814053 details
DYHC1_HUMANMK11_HUMANIntAct32814053 details
DYHC1_HUMANKTNA1_HUMANBioGRID16203747 details
DYHC1_HUMANBRCA1_HUMANBioGRID22990118 details
DYHC1_HUMANSMAD2_HUMANBioGRID, HPRD15231748 details
DYHC1_HUMANTET5A_HUMANBioGRID15231748 details
DYHC1_HUMAN1433T_HUMANBioGRID15161933 details
DYHC1_HUMANKPCD_HUMANBioGRID20395553 details
DYHC1_HUMANRHBD2_HUMANBioGRID32296183 details
DYHC1_HUMANCOX20_HUMANBioGRID32296183 details
DYHC1_HUMANSUMO2_HUMANBioGRID32786267 details
DYHC1_HUMANNEMO_HUMANIntAct14743216 details
DYHC1_HUMANTRAF6_HUMANIntAct17353931 details
DYHC1_HUMANGBRL2_HUMANIntAct17353931 details
DYHC1_HUMANPHLA3_HUMANIntAct17353931 details
DYHC1_HUMANPP4C_HUMANIntAct17353931 details
DYHC1_HUMANMAGD1_HUMANIntAct17353931 details
DYHC1_HUMANPHB2_HUMANIntAct17353931 details
DYHC1_HUMANNDKB_HUMANBioGRID, IntAct17353931 details
DYHC1_HUMAN1433Z_HUMANMINT15161933 details
DYHC1_HUMANMAX_HUMANBioGRID, IntAct20195357 22939629 details
DYHC1_HUMANEF1D_HUMANIntAct20195357 details
DYHC1_HUMANCDC5L_HUMANBioGRID, MINT11101529 20467437 details
DYHC1_HUMANNF1_HUMANMINT23583712 details
DYHC1_HUMANDC1I2_HUMANBioGRID, IntAct, MINT22863883 24986880 26344197 26496610 28514442 28718761 34079125 details
DYHC1_HUMANDYL1_HUMANBioGRID, HPRD, IntAct14760703 26496610 details
DYHC1_HUMANDCTN4_HUMANBioGRID, IntAct26496610 28718761 details
DYHC1_HUMANDC1L1_HUMANBioGRID, IntAct22863883 22939629 26344197 26496610 28514442 28718761 details
DYHC1_HUMANDC1L2_HUMANBioGRID, IntAct22863883 22939629 26344197 26496610 28718761 details
DYHC1_HUMANDLRB1_HUMANBioGRID, IntAct22939629 26496610 28718761 details
DYHC1_HUMANDCTN1_HUMANBioGRID, IntAct14600259 22939629 22956769 26344197 26496610 26638075 34079125 details
DYHC1_HUMANNIN_HUMANBioGRID, IntAct26638075 28718761 details
DYHC1_HUMANNINL_HUMANBioGRID, IntAct26485645 26638075 28718761 details
DYHC1_HUMANDYLT1_HUMANBioGRID, IntAct22939629 26344197 26638075 27173435 28718761 unassigned1312 details
DYHC1_HUMANDC1I1_HUMANBioGRID, IntAct22956769 28514442 28718761 details
DYHC1_HUMANLRRK2_HUMANBioGRID, IntAct19826009 31046837 details
DYHC1_HUMANFMR1_HUMANIntAct31413325 details
DYHC1_HUMANBICD2_HUMANBioGRID, IntAct11483508 22956769 25512093 28718761 details
DYHC1_HUMANNDEL1_HUMANBioGRID, HPRD11163259 11163260 14970193 18784752 details
DYHC1_HUMANEPB41_HUMANBioGRID10189366 details
DYHC1_HUMANCSK2B_HUMANBioGRID21486957 details
DYHC1_HUMANELP1_HUMANBioGRID18303054 details
DYHC1_HUMANMT21A_HUMANBioGRID23349634 details
DYHC1_HUMANMT21C_HUMANBioGRID23349634 details
DYHC1_HUMANITA4_HUMANBioGRID22623428 details
DYHC1_HUMANSPRTN_HUMANBioGRID23254330 details
DYHC1_HUMANTRI58_HUMANBioGRID25241935 details
DYHC1_HUMANHDAC6_HUMANBioGRID25342804 details
DYHC1_HUMANRUFY1_HUMANBioGRID23144738 details
DYHC1_HUMANNUMA1_HUMANBioGRID26195665 details
DYHC1_HUMANATOH1_HUMANBioGRID27542412 details
DYHC1_HUMANATX3_HUMANBioGRID28180282 30455355 details
DYHC1_HUMANRAE1L_HUMANBioGRID29293652 details
DYHC1_HUMANUBP11_HUMANBioGRID29293652 details
DYHC1_HUMANDAPLE_HUMANBioGRID28718761 details
DYHC1_HUMANGRDN_HUMANBioGRID28718761 details
DYHC1_HUMANHOOK3_HUMANBioGRID28718761 details
DYHC1_HUMANISG15_HUMANBioGRID33024031 details
DYHC1_HUMAN1433G_HUMANHPRD15324660 details