Entity Details

Primary name SYLM_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15031
EntryNameSYLM_HUMAN
FullNameProbable leucine--tRNA ligase, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length903
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesLARS2

GO terms

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GOName
GO:0002161 aminoacyl-tRNA editing activity
GO:0004823 leucine-tRNA ligase activity
GO:0005524 ATP binding
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0006418 tRNA aminoacylation for protein translation
GO:0006429 leucyl-tRNA aminoacylation
GO:0032543 mitochondrial translation

Subcellular Location

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Subcellular Location
Mitochondrion matrix

Domains

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DomainNameCategoryType
IPR001412 Aminoacyl-tRNA synthetase, class I, conserved siteSiteConserved site
IPR002300 Aminoacyl-tRNA synthetase, class IaDomainDomain
IPR002302 Leucine-tRNA ligaseFamilyFamily
IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domainFamilyHomologous superfamily
IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-bindingFamilyHomologous superfamily
IPR013155 Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-bindingDomainDomain
IPR014729 Rossmann-like alpha/beta/alpha sandwich foldFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00149 LeucineDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
SYLM_HUMAN1433T_HUMANBioGRID15161933 details
SYLM_HUMANRHOU_HUMANBioGRID26598620 details