Entity Details

Primary name PTGIS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ16647
EntryNamePTGIS_HUMAN
FullNameProstacyclin synthase
TaxID9606
Evidenceevidence at protein level
Length500
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesPTGIS

GO terms

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GOName
GO:0001516 prostaglandin biosynthetic process
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005901 caveola
GO:0006690 icosanoid metabolic process
GO:0008116 prostaglandin-I synthase activity
GO:0016021 integral component of membrane
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0019371 cyclooxygenase pathway
GO:0020037 heme binding
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway
GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0045766 positive regulation of angiogenesis
GO:0050728 negative regulation of inflammatory response
GO:0071347 cellular response to interleukin-1
GO:0071354 cellular response to interleukin-6
GO:0071456 cellular response to hypoxia
GO:0097190 apoptotic signaling pathway
GO:0106256 hydroperoxy icosatetraenoate dehydratase activity
GO:1900119 positive regulation of execution phase of apoptosis

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR001128 Cytochrome P450FamilyFamily
IPR002403 Cytochrome P450, E-class, group IVFamilyFamily
IPR024204 Cytochrome P450, cholesterol 7-alpha-monooxygenase-typeFamilyFamily
IPR027286 Prostacyclin synthaseFamilyFamily
IPR036396 Cytochrome P450 superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00812 PhenylbutazoneDrugbanksmall molecule
DB01240 EpoprostenolDrugbanksmall molecule
DB08675 (5Z)-7-{(1R,4S,5R,6R)-6-[(1E)-1-Octen-1-yl]-2,3-diazabicyclo[2.2.1]hept-2-en-5-yl}-5-heptenoic acidDrugbanksmall molecule

Interactions

4 interactions