Entity Details

Primary name PTPN6
Entity type gene
Source Source Link

Details

PrimaryID5777
RefseqGene
SymbolPTPN6
Nameprotein tyrosine phosphatase non-receptor type 6
Chromosome12
Location12p13.31
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1998-08-19
ModificationDate2021-06-20

Ontological Relatives

UniProt IDsPTN6_HUMAN

GO terms

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GOName
GO:0001784 phosphotyrosine residue binding
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin
GO:0004725 protein tyrosine phosphatase activity
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005911 cell-cell junction
GO:0006470 protein dephosphorylation
GO:0007186 G protein-coupled receptor signaling pathway
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 membrane
GO:0017124 SH3 domain binding
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0019901 protein kinase binding
GO:0030154 cell differentiation
GO:0030168 platelet activation
GO:0030220 platelet formation
GO:0031295 T cell costimulation
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032991 protein-containing complex
GO:0033277 abortive mitotic cell cycle
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0035556 intracellular signal transduction
GO:0035580 specific granule lumen
GO:0035855 megakaryocyte development
GO:0042105 alpha-beta T cell receptor complex
GO:0042130 negative regulation of T cell proliferation
GO:0042169 SH2 domain binding
GO:0042267 natural killer cell mediated cytotoxicity
GO:0042981 regulation of apoptotic process
GO:0043312 neutrophil degranulation
GO:0043407 negative regulation of MAP kinase activity
GO:0045577 regulation of B cell differentiation
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0050839 cell adhesion molecule binding
GO:0050853 B cell receptor signaling pathway
GO:0050860 negative regulation of T cell receptor signaling pathway
GO:0050900 leukocyte migration
GO:0051279 regulation of release of sequestered calcium ion into cytosol
GO:0060338 regulation of type I interferon-mediated signaling pathway
GO:0070062 extracellular exosome
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070527 platelet aggregation
GO:0071345 cellular response to cytokine stimulus
GO:0140031 phosphorylation-dependent protein binding
GO:1904724 tertiary granule lumen
GO:1905867 epididymis development
GO:2000045 regulation of G1/S transition of mitotic cell cycle

Diseases

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Interactions

256 interactions

InteractorPartnerSourcesPublicationsLink
PTPN6ROS1BioGRID, HPRD, MINT11266449 17416557 details
PTPN6CD22BioGRID, HPRD, IntAct10228003 11356834 11551923 15588985 7618087 8627166 9890995 details
PTPN6MAP3K4MINT15601262 details
PTPN6TMEM62HPRD, IntAct16169070 details
PTPN6EPORBioGRID, HPRD, MINT7228577 7528537 7528577 7889566 details
PTPN6FCGR2BBioGRID, HPRD, MINT7716523 8577729 9148918 9603468 details
PTPN6KIR2DL3HPRD, MINT8574854 8648092 8691154 9148918 details
PTPN6PILRABioGRID, HPRD, UniProt10660620 10903717 details
PTPN6LAIR1BioGRID, HPRD, MINT, UniProt10660620 10764762 10903717 11160222 15703304 9285412 details
PTPN6GRB2BioGRID, HPRD, MINT, UniProt10660620 10747947 11964172 25535246 8632004 details
PTPN6SIRPABioGRID, HPRD, UniProt10660565 10660620 14662855 8943344 9632768 details
PTPN6ESR1HPRD, MINT7539106 details
PTPN6CDH2IntAct19167335 details
PTPN6PDGFRBBioGRID, IntAct19167335 9452499 details
PTPN6LCKBioGRID, HPRD, IntAct, MINT10488096 10574931 10617656 11294838 12468540 19167335 7512963 8114715 8692915 details
PTPN6KDRBioGRID, HPRD, MINT, Molecular Connections12887919 16453023 18377662 28065597 28183800 9405464 details
PTPN6CD33BioGRID, HPRD, MINT, UniProt10206955 10556798 17947393 24216507 details
PTPN6PIK3R1BioGRID, HPRD, MINT10488096 11160222 11337495 9452499 details
PTPN6CD300LFBioGRID, HPRD, MINT14662855 15184070 15549731 details
PTPN6IL4RBioGRID, HPRD, MINT11714803 27742835 9392697 details
PTPN6CSF2RBBioGRID, HPRD, MINT7528537 8246974 9162089 9254654 details
PTPN6PECAM1BioGRID, HPRD, MINT10350061 9774457 details
PTPN6SIGLEC10HPRD, MINT12163025 details
PTPN6EGFRBioGRID, HPRD, MINT22973453 25187647 28065597 7673163 9733788 details
PTPN6KITBioGRID, HPRD, MINT12614164 7684496 9528781 details
PTPN6LYNBioGRID, HPRD, IntAct10488096 10574931 10871605 11042209 12468540 22624718 8114715 8692915 details
PTPN6PTK2BioGRID, IntAct25814554 details
PTPN6OLIG1BioGRID, IntAct25814554 details
PTPN6FHL3BioGRID, IntAct25416956 details
PTPN6NFAT5DIP20351292 details
PTPN6IGF1RBioGRID, MINT28065597 details
PTPN6LMTK2BioGRID, MINT28065597 details
PTPN6AATKBioGRID, MINT28065597 details
PTPN6ERBB2BioGRID, MINT22973453 28065597 details
PTPN6ERBB3BioGRID, MINT22973453 28065597 details
PTPN6ROR1BioGRID, MINT28065597 details
PTPN6ROR2BioGRID, MINT28065597 details
PTPN6PTK7BioGRID, MINT28065597 details
PTPN6ERBB4BioGRID, MINT22973453 28065597 details
PTPN6FGFR2BioGRID, MINT12887919 28065597 details
PTPN6FGFR4BioGRID, MINT28065597 details
PTPN6CD72BioGRID, HPRD11114375 12882840 15588985 9590210 9740800 details
PTPN6PTK2BBioGRID, HPRD10521452 10747947 details
PTPN6SYKBioGRID, HPRD10072516 10747947 10871605 11356834 details
PTPN6LCP2BioGRID, HPRD15588985 8760799 9765283 details
PTPN6PAG1BioGRID, HPRD10790433 details
PTPN6HOXA10BioGRID, HPRD12145285 details
PTPN6TYK2BioGRID, HPRD7629131 8780698 details
PTPN6JAK1BioGRID, HPRD7629131 9520455 details
PTPN6VAV1BioGRID, HPRD8632004 details
PTPN6ZAP70BioGRID, HPRD10458769 8638162 details
PTPN6CTNND1BioGRID, HPRD10835420 details
PTPN6PRKCDBioGRID, HPRD11723252 details
PTPN6FCRL3BioGRID12051764 details
PTPN6LATBioGRID27221712 details
PTPN6PLCG2BioGRID27221712 details
PTPN6SRCBioGRID, HPRD10871605 12468645 14699166 8647855 9261115 details
PTPN6CDK1BioGRID14699166 details
PTPN6CCDC88ABioGRID21799016 details
PTPN6TRAF3BioGRID32779804 details
PTPN6PILRBHPRD9632768 details
PTPN6SIGLEC12HPRD11328818 details
PTPN6TLR10HPRD16482509 details
PTPN6SPATA2HPRD11160222 details
PTPN6KHDRBS1HPRD, IntAct9045636 details
PTPN6TFGHPRD, MINT15557341 details
PTPN6NTRK1BioGRID, MINT15557341 29715200 details
PTPN6CAV1BioGRID, HPRD, MINT12176037 details
PTPN6BTLAHPRD, MINT12796776 14652006 details
PTPN6PDCD1MINT15240681 details
PTPN6MPIG6BBioGRID, HPRD, MINT11544253 details
PTPN6TNFRSF1AHPRD, MINT11786908 details
PTPN6SH3BP2MINT16649996 details
PTPN6KIR2DL1MINT8691146 details
PTPN6CASP8MINT18086677 details
PTPN6CD37IntAct22624718 details
PTPN6THEMISMINT25535246 details
PTPN6CD244IntAct, UniProt11489943 24642916 details
PTPN6LILRB1BioGRID, IntAct18802077 9842885 details
PTPN6LOC102725035IntAct18802077 details
PTPN6LOC107987462IntAct18802077 details
PTPN6LILRB4IntAct18802077 details
PTPN6CAMK1DIP25915125 details
PTPN6INSRBioGRID, HPRD, MINT12468540 28065597 7512963 8114715 8692915 details
PTPN6BCRBioGRID, HPRD27432908 9211920 9788431 details
PTPN6ABL1BioGRID, HPRD10488096 10574931 12468540 7512963 8114715 8692915 details
PTPN6CXCR4BioGRID, HPRD10506573 details
PTPN6CBLBioGRID, HPRD12176909 details
PTPN6TREML1BioGRID, HPRD12393607 details
PTPN6JAK2BioGRID, HPRD10772872 8943354 details
PTPN6NOS1BioGRID, HPRD11511520 details
PTPN6GAB2BioGRID, HPRD11812650 11895767 details
PTPN6CD5BioGRID, HPRD10082557 details
PTPN6SSTR2BioGRID, HPRD11920268 9305905 details
PTPN6SOS1BioGRID, HPRD8632004 details
PTPN6SIGLEC11BioGRID, HPRD11986327 details
PTPN6BLNKBioGRID, HPRD10903736 11356834 15588985 details
PTPN6IL6STBioGRID, HPRD10800945 details
PTPN6LIFRBioGRID, HPRD10800945 details
PTPN6STAT5BBioGRID, HPRD9211920 details
PTPN6TXNBioGRID19561639 details
PTPN6PLCG1BioGRID27221712 details
PTPN6PTPN11BioGRID, HPRD27432908 8541543 details
PTPN6PTPN6BioGRID, HPRD11920268 27432908 31980649 7518460 8574854 9151699 9531263 9842885 9973385 details
PTPN6SIGLEC7BioGRID15703304 details
PTPN6SIGLEC9BioGRID15703304 details
PTPN6FGFRL1BioGRID23640895 details
PTPN6ITGA1BioGRID12887919 details
PTPN6TNFRSF25BioGRID28183800 details
PTPN6RNF6BioGRID29288235 30496760 details
PTPN6PDK1BioGRID19591923 details
PTPN6RNF38BioGRID30112836 details
PTPN6CLEC12ABioGRID15238421 details
PTPN6TRAF6BioGRID, HPRD14500659 31942069 details
PTPN6IFNAR1HPRD8524272 9029147 details
PTPN6GHRHPRD9632636 details
PTPN6DOK1HPRD10585470 details
PTPN6IRS4HPRD12774026 details
PTPN6CLEC4AHPRD11178971 details
PTPN6CUZD1HPRD12361947 15588985 details
PTPN6KLRB1HPRD10229828 details
PTPN6CEACAM1HPRD9867848 details
PTPN6CTNNB1HPRD12571228 15588985 details
PTPN6ACTN4HPRD15070900 15588985 details
PTPN6MS4A2HPRD9379041 details
PTPN6KIR2DL5AHPRD15187115 details
PTPN6MYH9HPRD12705885 details
PTPN6FLT3HPRD15831474 details
PTPN6PRKCAHPRD15269224 details
PTPN6ACTN1HPRD15070900 details
PTPN6IRS2HPRD12198247 details
PTPN6CD79AHPRD7539038 details
PTPN6FASHPRD11786908 details
PTPN6IL2RBHPRD9520455 details
PTPN6CD79BHPRD7539038 details
PTPN6CD247HPRD14672952 details
PTPN6JAK3HPRD9520455 details
PTPN6SHC1HPRD8541543 details
PTPN6STAT6HPRD12791978 details
PTPN6PTPRCHPRD10228003 9368621 details
PTPN6KLRC1HPRD9485206 details
PTPN6SMAD3BioGRID, IntAct18729074 details
PTPN6ANXA1IntAct23754495 details
PTPN6PSMD13BioGRID, IntAct28330616 details
PTPN6PSMD2BioGRID, IntAct28330616 details
PTPN6PSMD4BioGRID, IntAct28330616 details
PTPN6PSMD1BioGRID, IntAct28330616 details
PTPN6PSMC5BioGRID, IntAct28330616 details
PTPN6PSMD7BioGRID, IntAct28330616 details
PTPN6PSMD3BioGRID, IntAct28330616 details
PTPN6PSMD11BioGRID, IntAct28330616 details
PTPN6DUSP22BioGRID, IntAct28330616 details
PTPN6SLAMF6BioGRID, HPRD, IntAct11489943 details
PTPN6CD300AIntAct11489943 details
PTPN6NSUN7BioGRID, IntAct26186194 28514442 details
PTPN6PTPN12BioGRID, IntAct27432908 28514442 31980649 details
PTPN6PTDSS1BioGRID, IntAct31980649 details
PTPN6RPL35ABioGRID, IntAct27432908 28675297 31980649 details
PTPN6RPL7BioGRID, IntAct31980649 details
PTPN6RPL13BioGRID, IntAct28675297 31980649 details
PTPN6RPL10BioGRID, IntAct28675297 31980649 details
PTPN6RPL10LBioGRID, IntAct31980649 details
PTPN6RPL12BioGRID, IntAct31980649 details
PTPN6RPL4BioGRID, IntAct28675297 31980649 details
PTPN6RPL13ABioGRID, IntAct31980649 details
PTPN6RPL35BioGRID, IntAct31980649 details
PTPN6RPL21BioGRID, IntAct28675297 31980649 details
PTPN6RPL28BioGRID, IntAct31980649 details
PTPN6RPL34BioGRID, IntAct31980649 details
PTPN6RPL14BioGRID, IntAct31980649 details
PTPN6RPL26BioGRID, IntAct31980649 details
PTPN6RPL15BioGRID, IntAct31980649 details
PTPN6RPL27BioGRID, IntAct31980649 details
PTPN6RPL37ABioGRID, IntAct27432908 31980649 details
PTPN6RPL7ABioGRID, IntAct28675297 31980649 details
PTPN6RPL39BioGRID, IntAct31980649 details
PTPN6RPL11BioGRID, IntAct31980649 details
PTPN6RPL8BioGRID, IntAct31980649 details
PTPN6RPL19BioGRID, IntAct31980649 details
PTPN6RPL18ABioGRID, IntAct27432908 31980649 details
PTPN6RPL6BioGRID, IntAct31980649 details
PTPN6SMARCC2BioGRID, IntAct31980649 details
PTPN6C8orf33BioGRID, IntAct27432908 31980649 details
PTPN6RRP15BioGRID, IntAct31980649 details
PTPN6RPL36BioGRID, IntAct31980649 details
PTPN6NME1BioGRID, IntAct31980649 details
PTPN6RPL22BioGRID, IntAct31980649 details
PTPN6RPL5BioGRID, IntAct28675297 31980649 details
PTPN6RPL29BioGRID, IntAct31980649 details
PTPN6RPL37BioGRID, IntAct31980649 details
PTPN6RPL23ABioGRID, IntAct28675297 31980649 details
PTPN6RPL32BioGRID, IntAct28675297 31980649 details
PTPN6RPL18BioGRID, IntAct31980649 details
PTPN6AKAP9BioGRID, IntAct31980649 details
PTPN6SAMD4BBioGRID22939629 details
PTPN6PANK4BioGRID22939629 details
PTPN6AIMP1BioGRID26344197 details
PTPN6DARS1BioGRID26344197 details
PTPN6PTPN2BioGRID26344197 details
PTPN6PFKPBioGRID26344197 details
PTPN6TRIP6BioGRID26344197 details
PTPN6VARS1BioGRID26344197 details
PTPN6DUSP18BioGRID27880917 details
PTPN6NUDT16BioGRID27432908 details
PTPN6NMNAT1BioGRID27432908 details
PTPN6MACROD1BioGRID27432908 details
PTPN6RPL7L1BioGRID27432908 details
PTPN6RPS19BP1BioGRID27432908 details
PTPN6BRIX1BioGRID27432908 details
PTPN6SRP14BioGRID27432908 details
PTPN6RPL36ALBioGRID27432908 details
PTPN6GADD45GIP1BioGRID27432908 details
PTPN6RPL30BioGRID27432908 details
PTPN6EBNA1BP2BioGRID27432908 28675297 details
PTPN6DIMT1BioGRID27432908 28675297 details
PTPN6RPF2BioGRID27432908 details
PTPN6RRS1BioGRID27432908 details
PTPN6SRSF5BioGRID27432908 28675297 details
PTPN6CLTCL1BioGRID27432908 details
PTPN6PA2G4BioGRID27432908 details
PTPN6RPL22L1BioGRID27432908 details
PTPN6RPP30BioGRID27432908 details
PTPN6PLEKHA2BioGRID19786618 details
PTPN6ALYREFBioGRID28675297 details
PTPN6ASCC3BioGRID28675297 details
PTPN6C7orf50BioGRID28675297 details
PTPN6CDC5LBioGRID28675297 details
PTPN6CDC73BioGRID28675297 details
PTPN6CKAP5BioGRID28675297 details
PTPN6CTR9BioGRID28675297 details
PTPN6DDX27BioGRID28675297 details
PTPN6DDX54BioGRID28675297 details
PTPN6DHX29BioGRID28675297 details
PTPN6EIF2S2BioGRID28675297 details
PTPN6EXOSC10BioGRID28675297 details
PTPN6HNRNPA1L2BioGRID28675297 details
PTPN6LEO1BioGRID28675297 details
PTPN6NCLBioGRID28675297 details
PTPN6NOP2BioGRID28675297 details
PTPN6PEX2BioGRID28675297 details
PTPN6PRRC2ABioGRID28675297 details
PTPN6PTPN1BioGRID28675297 details
PTPN6PTPN20BioGRID28675297 details
PTPN6PWP1BioGRID28675297 details
PTPN6RBM28BioGRID28675297 details
PTPN6RPL10ABioGRID28675297 details
PTPN6RPL17BioGRID28675297 details
PTPN6RPS17BioGRID28675297 details
PTPN6RRP1BBioGRID28675297 details
PTPN6SRPK1BioGRID28675297 details
PTPN6SRRM1BioGRID28675297 details
PTPN6SRSF1BioGRID28675297 details
PTPN6SRSF3BioGRID28675297 details
PTPN6SRSF4BioGRID28675297 details
PTPN6ZRANB2BioGRID28675297 details
PTPN6DDX58BioGRID32513696 details