Entity Details

Primary name LRRK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ38SD2
EntryNameLRRK1_HUMAN
FullNameLeucine-rich repeat serine/threonine-protein kinase 1
TaxID9606
Evidenceevidence at protein level
Length2015
SequenceStatuscomplete
DateCreated2006-05-02
DateModified2021-06-02

Ontological Relatives

GenesLRRK1

GO terms

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GOName
GO:0004722 protein serine/threonine phosphatase activity
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0007165 signal transduction
GO:0036035 osteoclast development
GO:0042802 identical protein binding
GO:0043231 intracellular membrane-bounded organelle
GO:0045453 bone resorption
GO:0046872 metal ion binding
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1902533 positive regulation of intracellular signal transduction

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001611 Leucine-rich repeatRepeatRepeat
IPR002110 Ankyrin repeatRepeatRepeat
IPR003591 Leucine-rich repeat, typical subtypeRepeatRepeat
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR020683 Ankyrin repeat-containing domainDomainDomain
IPR020859 Roc domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR032171 C-terminal of Roc (COR) domainDomainDomain
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR036322 WD40-repeat-containing domain superfamilyFamilyHomologous superfamily
IPR036770 Ankyrin repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

83 interactions

InteractorPartnerSourcesPublicationsLink
LRRK1_HUMANABL1_HUMANBioGRID, IntAct20697350 24947832 29513927 details
LRRK1_HUMANLRRK1_HUMANBioGRID, IntAct19712061 22952686 details
LRRK1_HUMANBAG5_HUMANBioGRID, IntAct24510904 24947832 29513927 details
LRRK1_HUMANEGFR_HUMANBioGRID, IntAct24947832 28065597 29513927 details
LRRK1_HUMANGAK_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANCCL21_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANTEX33_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANCD2B2_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANSCEL_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANBAG2_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANBAG3_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANSCG1_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANRET_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANGNAZ_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANGRL1A_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANFGFR2_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANMATK_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANEPHA8_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANVGFR3_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANECHM_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANPDCD4_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANCBLB_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANTIRAP_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANVGLL4_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANSKT_HUMANIntAct24947832 details
LRRK1_HUMANBL1S5_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANCLVS1_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANODFP2_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANSNX21_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANITCH_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANNEK1_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANCKAP2_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANBAG1_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANTCF25_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANTIRR_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANFOXP1_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANCWC15_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANGPBL1_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANLMA1L_HUMANIntAct24947832 details
LRRK1_HUMANPAK6_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANBORG2_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANTR112_HUMANIntAct24947832 details
LRRK1_HUMANCHIP_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANSNX9_HUMANBioGRID, IntAct24947832 29513927 details
LRRK1_HUMANPLK1_HUMANBioGRID, DIP26192437 29513927 details
LRRK1_HUMANITAV_HUMANIntAct32814053 details
LRRK1_HUMANCK052_HUMANBioGRID29513927 details
LRRK1_HUMANMYZAP_HUMANBioGRID29513927 details
LRRK1_HUMANGL1AD_HUMANBioGRID29513927 details
LRRK1_HUMANENKUR_HUMANBioGRID29513927 details
LRRK1_HUMANF184A_HUMANBioGRID29513927 details
LRRK1_HUMANTEC_HUMANBioGRID29513927 details
LRRK1_HUMANCPLX3_HUMANBioGRID29513927 details
LRRK1_HUMANSH22A_HUMANBioGRID29513927 details
LRRK1_HUMANKI20A_HUMANBioGRID29513927 details
LRRK1_HUMANMTG1_HUMANBioGRID29513927 details
LRRK1_HUMANRAB7L_HUMANBioGRID29513927 details
LRRK1_HUMANFXL14_HUMANBioGRID29513927 details
LRRK1_HUMANGRB2_HUMANBioGRID, IntAct19380743 20697350 24947832 31980649 details
LRRK1_HUMANLRRK2_HUMANBioGRID, IntAct19712061 20144646 details
LRRK1_HUMANDAPK1_HUMANBioGRID, IntAct19712061 details
LRRK1_HUMANSHC1_HUMANBioGRID, IntAct20697350 24947832 31980649 details
LRRK1_HUMANCK5P2_HUMANDIP26192437 details
LRRK1_HUMANSQSTM_HUMANBioGRID, IntAct29519959 details
LRRK1_HUMANTCPB_HUMANBioGRID20697350 details
LRRK1_HUMANFKBP5_HUMANBioGRID20697350 details
LRRK1_HUMANCDC37_HUMANBioGRID20697350 details
LRRK1_HUMANDNJA1_HUMANBioGRID20697350 details
LRRK1_HUMANNEDD4_HUMANBioGRID20697350 details
LRRK1_HUMANNP1L1_HUMANBioGRID20697350 details
LRRK1_HUMANVAPA_HUMANBioGRID20697350 details
LRRK1_HUMANSHIP1_HUMANBioGRID20697350 details
LRRK1_HUMANDOK3_HUMANBioGRID20697350 details
LRRK1_HUMANGAB2_HUMANBioGRID20697350 details
LRRK1_HUMANSHIP2_HUMANBioGRID20697350 details
LRRK1_HUMANPTN11_HUMANBioGRID20697350 details
LRRK1_HUMANM4K1_HUMANBioGRID20697350 details
LRRK1_HUMANASAP1_HUMANBioGRID20697350 details
LRRK1_HUMANSOS2_HUMANBioGRID20697350 details
LRRK1_HUMANSOS1_HUMANBioGRID20697350 details
LRRK1_HUMANHNRPK_HUMANBioGRID20697350 details
LRRK1_HUMANRSU1_HUMANBioGRID20697350 details
LRRK1_HUMANHS90A_HUMANBioGRID29519959 details