Entity Details

Primary name ITCH
Entity type gene
Source Source Link

Details

PrimaryID83737
RefseqGeneNG_023206
SymbolITCH
Nameitchy E3 ubiquitin protein ligase
Chromosome20
Location20q11.22
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate2001-04-27
ModificationDate2021-06-11

Ontological Relatives

UniProt IDsITCH_HUMAN

GO terms

Show/Hide Table
GOName
GO:0000209 protein polyubiquitination
GO:0001558 regulation of cell growth
GO:0004842 ubiquitin-protein transferase activity
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0007219 Notch signaling pathway
GO:0016020 membrane
GO:0016567 protein ubiquitination
GO:0031410 cytoplasmic vesicle
GO:0031901 early endosome membrane
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032480 negative regulation of type I interferon production
GO:0032991 protein-containing complex
GO:0035519 protein K29-linked ubiquitination
GO:0043021 ribonucleoprotein complex binding
GO:0043066 negative regulation of apoptotic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043231 intracellular membrane-bounded organelle
GO:0044389 ubiquitin-like protein ligase binding
GO:0045087 innate immune response
GO:0045236 CXCR chemokine receptor binding
GO:0045732 positive regulation of protein catabolic process
GO:0046329 negative regulation of JNK cascade
GO:0046718 viral entry into host cell
GO:0050687 negative regulation of defense response to virus
GO:0051607 defense response to virus
GO:0051865 protein autoubiquitination
GO:0061630 ubiquitin protein ligase activity
GO:0070062 extracellular exosome
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0070534 protein K63-linked ubiquitination
GO:0070936 protein K48-linked ubiquitination
GO:0090085 regulation of protein deubiquitination
GO:1902036 regulation of hematopoietic stem cell differentiation
GO:1990763 arrestin family protein binding
GO:2000646 positive regulation of receptor catabolic process

Diseases

Show/Hide Table

Interactions

236 interactions

InteractorPartnerSourcesPublicationsLink
ITCHSH3GL2BioGRID, HPRD, MINT14684745 26613292 28235806 details
ITCHNEDD9BioGRID, HPRD, MINT15051726 details
ITCHCBLCBioGRID, HPRD, MINT12226085 details
ITCHC8orf44-SGK3MINT16888620 details
ITCHSGK3BioGRID, HPRD, MINT16888620 details
ITCHDTX1BioGRID, HPRD, MINT17028573 18628966 details
ITCHTP73BioGRID, DIP, HPRD, MINT15678106 17110958 17592138 30603043 32513985 details
ITCHUBBIntAct17719543 details
ITCHUBE2E2BioGRID, IntAct19549727 30017913 details
ITCHUBCBioGRID, MINT19343052 22496338 23287719 23644597 25723849 30017913 details
ITCHSPARTBioGRID, IntAct16055720 19307600 19580544 19765186 20504295 28514442 details
ITCHSNX9BioGRID, MINT20491914 details
ITCHMLANABioGRID, MINT15703212 20491914 details
ITCHRNF11BioGRID, HPRD, I2D14559117 19131965 20676133 22507528 28292929 31985874 details
ITCHGLI1BioGRID, I2D20818436 31278361 details
ITCHWASLBioGRID, IntAct23414517 details
ITCHCYLDBioGRID, InnateDB22057290 details
ITCHPI4K2AMINT23146885 details
ITCHLRRK1BioGRID, IntAct24947832 29513927 details
ITCHTP53BP2BioGRID, MINT25436413 28400336 details
ITCHARRDC3BioGRID, IntAct23236378 28514442 29416926 details
ITCHARRDC1BioGRID, IntAct21191027 23236378 23886940 26186194 28514442 details
ITCHCPSF6BioGRID, HPRD, IntAct16055720 26508657 28514442 details
ITCHTP63BioGRID, DIP16908849 20855944 22935697 23370280 25485500 details
ITCHN4BP1BioGRID, DIP17592138 details
ITCHERBB4BioGRID, DIP17463226 18334649 details
ITCHJPH3IntAct32814053 details
ITCHNUMBBioGRID, HPRD12682059 18628966 20818436 details
ITCHSCNN1ABioGRID11244092 details
ITCHSCNN1BBioGRID11244092 details
ITCHATN1BioGRID, HPRD9647693 details
ITCHCXCR4BioGRID19116316 22275353 24489825 28264927 details
ITCHARRB2BioGRID17947233 18544533 details
ITCHITCHBioGRID, HPRD11526121 11724934 16055720 16446428 17038327 17592138 17719543 17996703 18718449 19997087 22496338 23146885 24790097 26949039 28475870 28747490 31578285 details
ITCHNFE2BioGRID11318614 18718448 details
ITCHUBE2L3BioGRID15350225 15678106 17038327 17592138 17719543 17996703 18718449 20068034 22009753 25632008 25723849 26245901 26949039 27182664 29212706 29378950 29515120 29643511 30017913 details
ITCHUSP9XBioGRID17038327 19341794 26508657 details
ITCHJUNBioGRID, HPRD16901904 17110928 19806201 19818398 details
ITCHFYNBioGRID16387660 details
ITCHSMAD3BioGRID15051726 details
ITCHPOLR2ABioGRID, HPRD16055720 26508657 details
ITCHNUDT21BioGRID16055720 details
ITCHUBAP2LBioGRID16055720 details
ITCHOCLNBioGRID, HPRD11782481 19478092 33100129 34079125 details
ITCHMAP2K4BioGRID19737936 details
ITCHLATS1BioGRID21212414 21383157 23564455 24107629 28416659 34079125 details
ITCHLAPTM5BioGRID22009753 details
ITCHSMAD2BioGRID15350225 details
ITCHSTAMBioGRID22275353 26508657 details
ITCHSTAM2BioGRID22275353 details
ITCHARHGEF7BioGRID17652093 26613292 28235806 details
ITCHPRKACABioGRID17437719 details
ITCHCSNK2A1BioGRID17437719 details
ITCHTXNIPBioGRID20068034 26527736 27437069 29378950 32901881 details
ITCHMAPK8BioGRID16446428 details
ITCHDVL2BioGRID22826439 26701932 details
ITCHBECN1BioGRID21936852 details
ITCHLITAFBioGRID21326863 25963657 details
ITCHGNAI2BioGRID23071112 details
ITCHUBE2E1BioGRID15350225 19737936 30017913 details
ITCHUBE2G1BioGRID16446428 22826439 details
ITCHUBE2D2BioGRID11724934 22496338 25723849 26245901 29643511 30017913 details
ITCHUBE2E3BioGRID22496338 details
ITCHUBE2J2BioGRID22496338 details
ITCHCDC34BioGRID22496338 30017913 details
ITCHUBE2KBioGRID22496338 30017913 details
ITCHPOU5F1BioGRID19997087 23255053 details
ITCHRASSF5BioGRID23538446 32690868 details
ITCHUBE2D3BioGRID23644597 25723849 30017913 details
ITCHARID1ABioGRID16055720 details
ITCHURI1BioGRID16055720 details
ITCHEWSR1BioGRID16055720 details
ITCHPOLR2BBioGRID16055720 details
ITCHPOLR2CBioGRID16055720 details
ITCHPOLR2EBioGRID16055720 details
ITCHSMARCC1BioGRID16055720 details
ITCHSMARCC2BioGRID16055720 details
ITCHSMARCE1BioGRID16055720 details
ITCHDAZAP1BioGRID16055720 details
ITCHRPAP2BioGRID16055720 details
ITCHHNRNPLBioGRID16055720 28611215 details
ITCHHNRNPUL1BioGRID16055720 details
ITCHCPSF7BioGRID16055720 details
ITCHPABPC1BioGRID16055720 details
ITCHSF1BioGRID16055720 details
ITCHRPAP3BioGRID16055720 details
ITCHUBAP2BioGRID16055720 details
ITCHWBP2BioGRID16055720 26508657 27578003 details
ITCHDTX3LBioGRID24790097 details
ITCHKPNB1BioGRID23538446 details
ITCHNDFIP1BioGRID25632008 26245901 28747490 details
ITCHTAB1BioGRID25714464 details
ITCHUBE2D1BioGRID25723849 28747490 30017913 details
ITCHGLIS3BioGRID26147758 details
ITCHBIN1BioGRID26613292 28235806 details
ITCHPACSIN1BioGRID26613292 28235806 details
ITCHITSN1BioGRID26613292 details
ITCHSMN1BioGRID26908624 details
ITCHUBE2MBioGRID27245101 details
ITCHJUNBBioGRID27245101 28747490 details
ITCHMARVELD2BioGRID28436082 33100129 details
ITCHSH3GL1BioGRID28235806 details
ITCHSUFUBioGRID29515120 details
ITCHUBE2CBioGRID30017913 details
ITCHUBE2D4BioGRID30017913 details
ITCHUBE2OBioGRID30017913 details
ITCHUBE2Q1BioGRID30017913 details
ITCHUBE2Q2BioGRID30017913 details
ITCHUBE2R2BioGRID30017913 details
ITCHBRAFBioGRID31015455 details
ITCHRAF1BioGRID31015455 details
ITCHMAP2K1BioGRID31015455 details
ITCHNRASBioGRID31015455 details
ITCHKSR1BioGRID31015455 details
ITCHYWHAQBioGRID31015455 details
ITCHPRRG4BioGRID23873930 details
ITCHCBLBioGRID, HPRD, MINT12226085 19341794 details
ITCHSFNBioGRID, MINT15778465 details
ITCHSNX18BioGRID, MINT20491914 details
ITCHFBXL15BioGRID, MINT21572392 details
ITCHTP53BioGRID, DIP16908849 18559494 21474069 32807901 details
ITCHRIPK1BioGRID, HPRD19131965 details
ITCHARRB1BioGRID17947233 18544533 details
ITCHCFLARBioGRID18559494 19090833 19808964 21474069 30736843 31443721 details
ITCHYAP1BioGRID17110958 details
ITCHSMAD7BioGRID15946939 22773947 28400336 details
ITCHHGSBioGRID14602072 26508657 details
ITCHBIDBioGRID20392206 details
ITCHNDFIP2BioGRID, HPRD15252135 20522958 details
ITCHTRPV4BioGRID, HPRD17110928 20650893 details
ITCHSH3GLB1BioGRID19341794 details
ITCHTNFRSF10BBioGRID19808964 details
ITCHTGFBR1BioGRID15350225 details
ITCHAMOTBioGRID22385262 23564455 24101513 details
ITCHTAX1BP1BioGRID18246070 details
ITCHTRAF6BioGRID18246070 details
ITCHCAV1BioGRID22275353 details
ITCHMAVSBioGRID19881509 27736772 details
ITCHPCBP2BioGRID19881509 details
ITCHDVL1BioGRID22826439 details
ITCHDVL3BioGRID22826439 28455968 details
ITCHUSP12BioGRID22778262 26811477 details
ITCHWDR48BioGRID22778262 details
ITCHKLF10BioGRID18278048 details
ITCHMDM2BioGRID21093410 26025930 details
ITCHGBABioGRID23255161 details
ITCHMGRN1BioGRID23253940 details
ITCHNOTCH1BioGRID, HPRD12682059 23886940 details
ITCHWWOXBioGRID24550385 25331887 details
ITCHSMAD6BioGRID24850914 details
ITCHHTTBioGRID24865853 details
ITCHATXN3BioGRID24865853 details
ITCHPTCH1BioGRID25092867 details
ITCHGSNBioGRID25246592 details
ITCHGGA3BioGRID25195858 details
ITCHNCOA1BioGRID16051665 details
ITCHMAP3K7BioGRID25632008 details
ITCHLDLRAD3BioGRID26854353 details
ITCHIKBKBBioGRID26603838 details
ITCHPDCD6IPBioGRID26508657 details
ITCHCOL18A1BioGRID26508657 details
ITCHHDAC6BioGRID26508657 details
ITCHKPNA2BioGRID26508657 details
ITCHLRRK2BioGRID26508657 details
ITCHPCNABioGRID26508657 details
ITCHSCAMP3BioGRID26508657 details
ITCHSLC1A5BioGRID26508657 details
ITCHSLC3A2BioGRID26508657 details
ITCHUBA1BioGRID26508657 details
ITCHUBA6BioGRID26508657 details
ITCHUSP5BioGRID26508657 details
ITCHWWP1BioGRID26508657 details
ITCHGEMIN8BioGRID26908624 details
ITCHDDX20BioGRID26908624 details
ITCHRASSF1BioGRID27292796 details
ITCHMTSS1BioGRID28264927 details
ITCHYOD1BioGRID28416659 details
ITCHLRP6BioGRID28966723 details
ITCHARAFBioGRID31015455 details
ITCHERBB3BioGRID31443721 details
ITCHANKRD13ABioGRID31985874 details
ITCHTNFRSF1ABioGRID32690868 details
ITCHBAXBioGRID32690868 details
ITCHTRPC4HPRD17110928 details
ITCHTRPV1HPRD17110928 details
ITCHUSP13BioGRID, IntAct19615732 details
ITCHTOLLIPBioGRID, IntAct21903422 details
ITCHCUL3BioGRID, IntAct21145461 details
ITCHARRDC4BioGRID, IntAct23236378 details
ITCHADRB2BioGRID, IntAct23236378 details
ITCHFAM189BBioGRID, IntAct26186194 28514442 details
ITCHFAM189A2BioGRID, IntAct26186194 28514442 details
ITCHLDLRAD4BioGRID, IntAct26186194 28514442 details
ITCHTMEM255ABioGRID, IntAct26186194 28514442 details
ITCHTMEM51BioGRID, IntAct26186194 28514442 details
ITCHWBP1BioGRID, IntAct26186194 28514442 details
ITCHTMEM171BioGRID, IntAct26186194 28514442 details
ITCHGRAP2BioGRID, IntAct26186194 28514442 details
ITCHTMEM92BioGRID, IntAct26186194 28514442 details
ITCHILDR1BioGRID, IntAct28514442 details
ITCHSARAFBioGRID, IntAct28514442 details
ITCHDDR1MINT22057045 details
ITCHECI2IntAct29426014 details
ITCHECH1IntAct29426014 details
ITCHCFTRBioGRID, IntAct26618866 29924966 details
ITCHSH3GL3BioGRID, IntAct31980649 details
ITCHDISC1BioGRID, MINT29961565 details
ITCHEGFRBioGRID24797263 details
ITCHPLEKHB2BioGRID26186194 details
ITCHGRB2BioGRID26344197 details
ITCHWWP2BioGRID25071155 details
ITCHUBE2L6BioGRID27684187 details
ITCHTNIP2BioGRID27609421 details
ITCHHAVCR1BioGRID29742433 details
ITCHKDM6BBioGRID30224337 details
ITCHMYCBioGRID29467282 details
ITCHKRASBioGRID30639242 34079125 details
ITCHPHBBioGRID27025967 details
ITCHLMBR1LBioGRID31073040 details
ITCHPLEKHA4BioGRID31091453 details
ITCHTRIM66BioGRID31753913 details
ITCHFBXO42BioGRID31549767 details
ITCHDNAJC5BioGRID33957083 details
ITCHCGRRF1BioGRID32614325 details
ITCHMARCHF3BioGRID32614325 details
ITCHMARCHF8BioGRID32614325 details
ITCHRNF128BioGRID32614325 details
ITCHC11orf52BioGRID34079125 details
ITCHELOVL5BioGRID34079125 details
ITCHERGIC2BioGRID34079125 details
ITCHLAMTOR1BioGRID34079125 details
ITCHRAB9ABioGRID34079125 details
ITCHELAVL1BioGRID19322201 details
ITCHVIRMABioGRID29507755 details
ITCHAGO2BioGRID32392088 details
ITCHDDX58BioGRID32513696 details