Entity Details

Primary name FOXE1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO00358
EntryNameFOXE1_HUMAN
FullNameForkhead box protein E1
TaxID9606
Evidenceevidence at protein level
Length373
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesFOXE1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006590 thyroid hormone generation
GO:0009653 anatomical structure morphogenesis
GO:0016477 cell migration
GO:0030154 cell differentiation
GO:0030878 thyroid gland development
GO:0031069 hair follicle morphogenesis
GO:0043565 sequence-specific DNA binding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048538 thymus development
GO:0048562 embryonic organ morphogenesis
GO:0060022 hard palate development
GO:0060023 soft palate development
GO:0060465 pharynx development
GO:1904888 cranial skeletal system development
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001766 Fork head domainDomainDomain
IPR018122 Fork head domain conserved site1SiteConserved site
IPR030456 Fork head domain conserved site 2SiteConserved site
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
241850 OMIMBamforth-Lazarus syndrome (BLS)A disease characterized by thyroid agenesis, cleft palate and choanal atresia. The disease is caused by variants affecting the gene represented in this entry.
616534 OMIMThyroid cancer, non-medullary, 4 (NMTC4)A form of non-medullary thyroid cancer (NMTC), a cancer characterized by tumors originating from the thyroid follicular cells. NMTCs represent approximately 95% of all cases of thyroid cancer and are classified into papillary, follicular, Hurthle cell, and anaplastic neoplasms. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

3 interactions