Entity Details

Primary name RNF6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y252
EntryNameRNF6_HUMAN
FullNameE3 ubiquitin-protein ligase RNF6
TaxID9606
Evidenceevidence at protein level
Length685
SequenceStatuscomplete
DateCreated2001-02-21
DateModified2021-06-02

Ontological Relatives

GenesRNF6

GO terms

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GOName
GO:0004842 ubiquitin-protein transferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006355 regulation of transcription, DNA-templated
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
GO:0016605 PML body
GO:0030424 axon
GO:0030517 negative regulation of axon extension
GO:0031965 nuclear membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0044314 protein K27-linked ubiquitination
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046872 metal ion binding
GO:0050681 androgen receptor binding
GO:0060765 regulation of androgen receptor signaling pathway
GO:0061630 ubiquitin protein ligase activity
GO:0070936 protein K48-linked ubiquitination
GO:0085020 protein K6-linked ubiquitination

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001841 Zinc finger, RING-typeDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
133239 OMIMEsophageal cancer (ESCR)A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. The disease may be caused by variants affecting the gene represented in this entry.

Interactions

41 interactions

InteractorPartnerSourcesPublicationsLink
RNF6_HUMANUBE2H_HUMANBioGRID, IntAct19549727 details
RNF6_HUMANANDR_HUMANBioGRID, IntAct19345326 28324045 details
RNF6_HUMANUB2D1_HUMANBioGRID19345326 details
RNF6_HUMANTRI23_HUMANBioGRID26871637 details
RNF6_HUMANGOGA2_HUMANBioGRID26871637 details
RNF6_HUMANK1C15_HUMANBioGRID26871637 details
RNF6_HUMANMDFI_HUMANBioGRID26871637 details
RNF6_HUMANMEOX2_HUMANBioGRID26871637 details
RNF6_HUMANTRI37_HUMANBioGRID26871637 details
RNF6_HUMANREL_HUMANBioGRID26871637 details
RNF6_HUMANTRI27_HUMANBioGRID26871637 details
RNF6_HUMANTAD2A_HUMANBioGRID26871637 details
RNF6_HUMANITF2_HUMANBioGRID26871637 details
RNF6_HUMANSTX11_HUMANBioGRID26871637 details
RNF6_HUMANMAGD1_HUMANBioGRID26871637 details
RNF6_HUMANMOONR_HUMANBioGRID26871637 details
RNF6_HUMANIKZF1_HUMANBioGRID26871637 details
RNF6_HUMANPNMA2_HUMANBioGRID26871637 details
RNF6_HUMANSAHH2_HUMANBioGRID26871637 details
RNF6_HUMANTRIM1_HUMANBioGRID26871637 details
RNF6_HUMANIKZF3_HUMANBioGRID26871637 details
RNF6_HUMANMTUS2_HUMANBioGRID26871637 details
RNF6_HUMANTNS2_HUMANBioGRID26871637 details
RNF6_HUMANLDOC1_HUMANBioGRID26871637 details
RNF6_HUMANTFP11_HUMANBioGRID26871637 details
RNF6_HUMANHOOK2_HUMANBioGRID26871637 details
RNF6_HUMANRPGR1_HUMANBioGRID26871637 details
RNF6_HUMANRINT1_HUMANBioGRID26871637 details
RNF6_HUMANCCD33_HUMANBioGRID26871637 details
RNF6_HUMANCEP70_HUMANBioGRID26871637 details
RNF6_HUMANTSG10_HUMANBioGRID26871637 details
RNF6_HUMANADIP_HUMANBioGRID26871637 details
RNF6_HUMANK1C40_HUMANBioGRID26871637 details
RNF6_HUMANMIPO1_HUMANBioGRID26871637 details
RNF6_HUMANCBY2_HUMANBioGRID26871637 details
RNF6_HUMANCCD57_HUMANBioGRID26871637 details
RNF6_HUMANLDB1_HUMANBioGRID12874135 details
RNF6_HUMANPTN6_HUMANBioGRID29288235 30496760 details
RNF6_HUMANTLE3_HUMANBioGRID29374067 30496760 details
RNF6_HUMANFOXA1_HUMANBioGRID30496760 details
RNF6_HUMANGCR_HUMANBioGRID31645658 details