Entity Details

Primary name IL23R_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ5VWK5
EntryNameIL23R_HUMAN
FullNameInterleukin-23 receptor
TaxID9606
Evidenceevidence at protein level
Length629
SequenceStatuscomplete
DateCreated2006-12-12
DateModified2021-06-02

Ontological Relatives

GenesIL23R

GO terms

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GOName
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0002230 positive regulation of defense response to virus by host
GO:0002827 positive regulation of T-helper 1 type immune response
GO:0004896 cytokine receptor activity
GO:0005886 plasma membrane
GO:0006954 inflammatory response
GO:0009897 external side of plasma membrane
GO:0010536 positive regulation of activation of Janus kinase activity
GO:0019221 cytokine-mediated signaling pathway
GO:0019955 cytokine binding
GO:0032496 response to lipopolysaccharide
GO:0032693 negative regulation of interleukin-10 production
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729 positive regulation of interferon-gamma production
GO:0032735 positive regulation of interleukin-12 production
GO:0032740 positive regulation of interleukin-17 production
GO:0032819 positive regulation of natural killer cell proliferation
GO:0034341 response to interferon-gamma
GO:0038155 interleukin-23-mediated signaling pathway
GO:0042102 positive regulation of T cell proliferation
GO:0042104 positive regulation of activated T cell proliferation
GO:0042509 regulation of tyrosine phosphorylation of STAT protein
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0043235 receptor complex
GO:0043382 positive regulation of memory T cell differentiation
GO:0045672 positive regulation of osteoclast differentiation
GO:0050829 defense response to Gram-negative bacterium
GO:0051135 positive regulation of NK T cell activation
GO:0072536 interleukin-23 receptor complex
GO:2000318 positive regulation of T-helper 17 type immune response
GO:2000330 positive regulation of T-helper 17 cell lineage commitment

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR003961 Fibronectin type IIIDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
612261 OMIMInflammatory bowel disease 17 (IBD17)A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

4 interactions