Entity Details

Primary name STK10_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO94804
EntryNameSTK10_HUMAN
FullNameSerine/threonine-protein kinase 10
TaxID9606
Evidenceevidence at protein level
Length968
SequenceStatuscomplete
DateCreated2001-01-24
DateModified2021-06-02

Ontological Relatives

GenesSTK10

GO terms

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GOName
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007049 cell cycle
GO:0035579 specific granule membrane
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043312 neutrophil degranulation
GO:0046777 protein autophosphorylation
GO:0070062 extracellular exosome
GO:0071593 lymphocyte aggregation
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:2000401 regulation of lymphocyte migration

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR022165 Polo kinase kinaseFamilyFamily
IPR042743 Serine/threonine-protein kinase 10, catalytic domainDomainDomain

Diseases

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Disease IDSourceNameDescription
273300 OMIMTesticular germ cell tumor (TGCT)A common malignancy in males representing 95% of all testicular neoplasms. TGCTs have various pathologic subtypes including: unclassified intratubular germ cell neoplasia, seminoma (including cases with syncytiotrophoblastic cells), spermatocytic seminoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, and teratoma. The disease may be caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
STK10_HUMANSTK10_HUMANHPRD, MINT17192257 18239682 details