Entity Details

Primary name CLIC1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO00299
EntryNameCLIC1_HUMAN
FullNameChloride intracellular channel protein 1
TaxID9606
Evidenceevidence at protein level
Length241
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesCLIC1

GO terms

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GOName
GO:0005244 voltage-gated ion channel activity
GO:0005254 chloride channel activity
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005886 plasma membrane
GO:0005903 brush border
GO:0006749 glutathione metabolic process
GO:0006821 chloride transport
GO:0007165 signal transduction
GO:0016020 membrane
GO:0031965 nuclear membrane
GO:0031982 vesicle
GO:0034707 chloride channel complex
GO:0034765 regulation of ion transmembrane transport
GO:0045296 cadherin binding
GO:0045669 positive regulation of osteoblast differentiation
GO:0048471 perinuclear region of cytoplasm
GO:0051726 regulation of cell cycle
GO:0051881 regulation of mitochondrial membrane potential
GO:0070062 extracellular exosome
GO:0070527 platelet aggregation
GO:0072562 blood microparticle

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Nucleus
Nucleus membrane

Domains

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DomainNameCategoryType
IPR002946 Intracellular chloride channelFamilyFamily
IPR004045 Glutathione S-transferase, N-terminalDomainDomain
IPR010987 Glutathione S-transferase, C-terminal-likeDomainDomain
IPR030259 Chloride intracellular channel protein 1FamilyFamily
IPR036249 Thioredoxin-like superfamilyFamilyHomologous superfamily
IPR036282 Glutathione S-transferase, C-terminal domain superfamilyFamilyHomologous superfamily
IPR040079 Glutathione Transferase familyFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB09130 CopperDrugbanksmall molecule
DB11638 ArtenimolDrugbanksmall molecule

Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
CLIC1_HUMANLSM1_HUMANBioGRID, HPRD, IntAct14667819 29395067 32296183 details
CLIC1_HUMANMLH1_HUMANIntAct20706999 details
CLIC1_HUMANAL5AP_HUMANBioGRID, IntAct21988832 details
CLIC1_HUMANAT5F1_HUMANBioGRID, IntAct21988832 details
CLIC1_HUMANVATL_HUMANBioGRID, IntAct21988832 details
CLIC1_HUMANVPP1_HUMANBioGRID, IntAct21988832 details
CLIC1_HUMANNTF4_HUMANBioGRID, IntAct21988832 details
CLIC1_HUMANCPT1A_HUMANBioGRID, IntAct21988832 details
CLIC1_HUMANZN184_HUMANBioGRID, IntAct21988832 details
CLIC1_HUMANRLA1_HUMANBioGRID, IntAct21988832 details
CLIC1_HUMANTHA_HUMANBioGRID, IntAct21988832 details
CLIC1_HUMANNEMO_HUMANBioGRID, IntAct21988832 details
CLIC1_HUMANNUP62_HUMANBioGRID, IntAct21988832 details
CLIC1_HUMANZN302_HUMANBioGRID, IntAct21988832 details
CLIC1_HUMANPRDX4_HUMANBioGRID, IntAct21988832 details
CLIC1_HUMANTPRN_HUMANBioGRID, IntAct28514442 32296183 details
CLIC1_HUMANNHSL2_HUMANBioGRID, IntAct32296183 details
CLIC1_HUMANPSD10_HUMANBioGRID, IntAct24338975 details
CLIC1_HUMANTPC2A_HUMANBioGRID, HPRD12681486 details
CLIC1_HUMANTPC2B_HUMANBioGRID, HPRD12681486 details
CLIC1_HUMANMYOC_HUMANBioGRID, HPRD16289162 details
CLIC1_HUMANMEOX2_HUMANBioGRID32296183 details
CLIC1_HUMANTPT1L_HUMANBioGRID32296183 details
CLIC1_HUMANCRCM_HUMANIntAct17353931 details
CLIC1_HUMANARF6_HUMANIntAct17353931 details
CLIC1_HUMANEPB41_HUMANIntAct17353931 details
CLIC1_HUMANHLAB_HUMANIntAct17353931 details
CLIC1_HUMANIKKE_HUMANIntAct17353931 details
CLIC1_HUMANAKAP9_HUMANBioGRID12163479 details
CLIC1_HUMANITA4_HUMANBioGRID22623428 details
CLIC1_HUMANU2AF2_HUMANBioGRID26641092 details
CLIC1_HUMANSUMO4_HUMANHPRD16236267 details