Entity Details

Primary name ADCY3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO60266
EntryNameADCY3_HUMAN
FullNameAdenylate cyclase type 3
TaxID9606
Evidenceevidence at protein level
Length1144
SequenceStatuscomplete
DateCreated2001-04-27
DateModified2021-06-02

Ontological Relatives

GenesADCY3

GO terms

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GOName
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0003091 renal water homeostasis
GO:0004016 adenylate cyclase activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005929 cilium
GO:0006171 cAMP biosynthetic process
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0007338 single fertilization
GO:0007340 acrosome reaction
GO:0007608 sensory perception of smell
GO:0008355 olfactory learning
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030317 flagellated sperm motility
GO:0034199 activation of protein kinase A activity
GO:0035556 intracellular signal transduction
GO:0046872 metal ion binding
GO:0071377 cellular response to glucagon stimulus
GO:1904322 cellular response to forskolin

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasm
Golgi apparatus

Domains

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DomainNameCategoryType
IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclaseDomainDomain
IPR018297 Adenylyl cyclase class-4/guanylyl cyclase, conserved siteSiteConserved site
IPR029787 Nucleotide cyclaseFamilyHomologous superfamily
IPR030672 Adenylate cyclaseFamilyFamily
IPR032628 Adenylate cyclase, N-terminalDomainDomain

Diseases

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Disease IDSourceNameDescription
601665 OMIMObesity (OBESITY)A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
ADCY3_HUMANMTR1B_HUMANBioGRID, IntAct26514267 details
ADCY3_HUMANADRB2_HUMANBioGRID24561123 details
ADCY3_HUMANSTML3_HUMANHPRD12122055 details